If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

If GLP-1 Drugs Are Good for Everything, Should We All Be on Them?

To read more of Derek's reporting on GLP-1 drugs, you can subscribe to his Substack here. GLP-1 drugs like Ozempic and Zepbound don't just help with Type 2 diabetes and weight loss. They seem to curb alcohol, cocaine, and tobacco use among addicts. In some studies, they prevent strokes, heart attacks, chronic kidney disease, sleep apnea, and Parkinson's disease. They’re associated with a lower risk of several cancers, including pancreatic cancer and multiple myeloma. Arthritic patients on the drugs experienced relief from knee pain that was “on par with opioid drugs.” A small study found that they reduce migraine headaches by 50 percent. And emerging research suggests they might even slow the rate of memory loss among people diagnosed with Alzheimer’s. Is all of this real? And if it’s real, how is one drug doing so many different things? And if it is doing all those things, why shouldn’t we be developing versions of the drug for just about everyone? Today we have two guests: David D’Alessio, chief of endocrinology and metabolism at the Duke University School of Medicine; and Randy Seeley, a professor of surgery, internal medicine, and nutritional sciences at the University of Michigan. We talk about how these drugs work—why they seem to do everything—and how our understanding of them could make them better, more effective, more broadly useful. If you have questions, observations, or ideas for future episodes, email us at PlainEnglish@Spotify.com. Host: Derek Thompson Guests: David D’Alessio and Randy Seeley Producer: Devon Baroldi Disclosure: Dr. Seeley has received research support from several pharmaceutical companies, including Eli Lilly, Diasome, and Amgen. Learn more about your ad choices. Visit podcastchoices.com/adchoices

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How Ukraine’s New Offensive Could Win the War Against Russia

How Ukraine’s New Offensive Could Win the War Against Russia

We're in a new phase of the Ukraine-Russia war. Paul Poast of the University of Chicago returns to the podcast to break down Ukraine's extraordinary counteroffensive. He explains why this counterattac...

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The UK Is in Trouble: Economic Crises, Energy Shocks, and the Queen’s Death

The UK Is in Trouble: Economic Crises, Energy Shocks, and the Queen’s Death

Hours before the death of Queen Elizabeth II, Derek talked to Duncan Weldon, the Britain economics correspondent at The Economist, about the UK's political and economic challenge. Russia’s invasion of...

8 Syys 202250min

America’s National Teacher Shortage: Looming Crisis or Media Myth?

America’s National Teacher Shortage: Looming Crisis or Media Myth?

Students are going back to school this month. But according to many news sources, there won't be nearly enough teachers to greet them. The Washington Post has warned of a “catastrophic teacher shortag...

6 Syys 202238min

Nate Silver on Why This Midterm Election Could Be the Weirdest in Decades

Nate Silver on Why This Midterm Election Could Be the Weirdest in Decades

Earlier this year, it appeared that Democrats were going to get destroyed in the midterms. Joe Biden's approval rating was in the toilet, inflation was raging, and everything was going wrong. It would...

2 Syys 202255min

The Messy Debate Over Student Loan Forgiveness

The Messy Debate Over Student Loan Forgiveness

The level of student debt in this country represents a massive policy error. But is forgiving up to $20,000 of student debt really the best way to help low-income Americans, or fix the nation's educat...

30 Elo 202242min

Burning Questions on Media: Streaming’s Summer of Hell, Movie Theater Woes, and CNN’s Risky Pivot

Burning Questions on Media: Streaming’s Summer of Hell, Movie Theater Woes, and CNN’s Risky Pivot

Today’s episode is about the entertainment and media industry’s tumultuous summer, the streaming wars, a come-to-Jesus moment for movie theaters, and a dramatic revamp at CNN—which tells a lot about t...

26 Elo 202250min

What’s the Secret of Success in America? This Economist Has Answers.

What’s the Secret of Success in America? This Economist Has Answers.

The economist Raj Chetty has spent much of the last decade trying to answer a very big question: What happened to the American Dream? In 1940, a child born into the average American household had a 92...

23 Elo 202250min

Why Does It Seem Like Everybody Hates Everything?

Why Does It Seem Like Everybody Hates Everything?

Bestselling author Chuck Klosterman talks to Derek about the death of the monoculture, how the internet creates cults of fans and anti-fans, and how “hating things” became a mainstream personality tra...

19 Elo 202252min

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