#282 - Longevity biomarkers for healthy aging and well-being | Dr. Matt Kaeberlein & Mike Haney

#282 - Longevity biomarkers for healthy aging and well-being | Dr. Matt Kaeberlein & Mike Haney

Longevity is a hot health topic, but what factors move the needle on not only how long you live but how long you experience relatively good health? Some lab and other tests can help assess how healthy you’re aging and provide context for what lifestyle and other changes to make. Dr. Matt Kaeberlein and Mike Haney discuss the tests that help assess healthy aging, how mental health and physical health are intricately connected, which lifestyle factors might expand your health span, and where the research stands on various longevity topics.


Get a Free Guide to Understanding Your Lab Results: https://levels.link/wnl


🎙 What Matt Kaeberlein, PhD, & Mike Haney discuss:

6:57 — Lifespan vs. health span vs. sick span

19:38 — Understanding sick span

27:44 — Biomarkers and other tests to assess health span

30:58 — The importance of emotional health for longevity

35:49 — Cellular tests may not have value for the consumer yet

42:24 — On mitochondrial function and telomere length

50:34 — Investing in your health

1:01:18 — Lifestyle changes can help make a big difference

1:09:50 — High vs. low protein

1:16:39 — When considering exercise, building muscle is crucial for longevity

1:27:37 — The prescription drug rapamycin is not FDA-approved for longevity


Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health.


Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health.


🔗 Helpful links:

Watch the conversation: https://youtu.be/OPH5Nb2a69o

Subscribe here on YouTube: https://youtube.com/levelshealth?sub_confirmation=1

Find us on YouTube: https://youtube.com/levelshealth?sub_confirmation=1

Matt Kaeberlein, PhD: https://www.optispan.life/matt-kaeberlein

Connect with Matt Kaeberlein, PhD, on X: https://x.com/mkaeberlein

Jaksot(287)

#265 - How do you know if you are healthy and what your labs tell you? | Dr. Robert Lustig & Mike Haney

#265 - How do you know if you are healthy and what your labs tell you? | Dr. Robert Lustig & Mike Haney

Although not one single test can tell you whether you are healthy, some biomarkers and lab results can provide you a picture of your metabolic health, which can then inform you about your overall health. Dr. Robert Lustig and Mike Haney discuss why fasting insulin is one of the best metabolic health biomarkers, how you can use continuous glucose monitoring as a proxy for insulin sensitivity, how fast your metabolic health can change, and why your uric acid level and the cholesterol marker ApoB are also important labs to receive. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Robert Lustig, MD, & Mike Haney discuss: (03:51) — Multiple factors help determine if you’re getting sicker or healthier (07:52) — Fasting glucose is not a good gauge of your metabolic health (10:13) — The concern with a rising insulin level (19:22) — A good goal is to keep glucose levels more stable, but you’re going to have rises (30:12) — What a glucose excursion can tell you (31:24) — Why doctors don’t check fasting insulin, even though it’s a better marker than glucose? (46:12) — How often should you get your fasting insulin checked? (50:08) — A continuous glucose monitor can show you your glucose excursions (58:42) — Why uric acid is an important biomarker (1:08:37) — Why you should get ApoB checked ⁠⁠⁠⁠⁠Transcript & Show notes⁠⁠⁠⁠⁠ 🔗 LINKS: Watch the full conversation: https://youtu.be/6P8HVIbdDc0?si=DIhrV0vlkQdYLskg

26 Syys 20241h 19min

#264 - How aging and menopause drive muscle loss and fat gain | Dr. Robert Lustig & Ben Grynol

#264 - How aging and menopause drive muscle loss and fat gain | Dr. Robert Lustig & Ben Grynol

Both aging and menopause affect metabolism. Unless people build and preserve muscle mass, aging drives muscle loss and fat gain. While these changes affect everyone, the menopause transition can also worsen metabolic health. Dr. Robert Lustig and Ben Grynol discuss aging’s effects on body composition, how menopause exacerbates these and other effects, and what you can do to protect your health. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Robert Lustig, MD, & Ben Grynol discuss: (03:05) — Aging and muscle loss (04:30) — Aging and fat gain (05:06) — Why insulin resistance can increase as we age (08:13) — Loss of estrogen drives menopause symptoms (09:28) — Menopause can also impact cholesterol (10:11) — Lifestyle changes can help lessen the impact of menopause on metabolism ⁠⁠⁠⁠Transcript & Show notes⁠⁠⁠⁠ 🔗 LINKS: Watch the full library for Rob’s Ultimate Health Guide: ⁠https://www.youtube.com/playlist?list=PLt_J9-Sfer-lwssEdcuNTm3mmKhKqgd-z

12 Syys 202411min

#263 - How do macronutrients affect your blood sugar and metabolic health? | Dr. Robert Lustig & Ben Grynol

#263 - How do macronutrients affect your blood sugar and metabolic health? | Dr. Robert Lustig & Ben Grynol

Macronutrients include fat, protein, and carbohydrates. Fiber is a type of carbohydrate. All four nutrients have different effects on glucose and metabolic health. Dr. Robert Lustig and Ben Grynol discuss the metabolic health effects of each macronutrient, how to prevent age-related muscle loss, how to improve gut health, and more. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Robert Lustig, MD, & Ben Grynol discuss: (03:36) — Protein helps prevent age-related muscle loss (04:25) — What if you just consume protein and do not exercise? (05:21) — Leucine is a stimulator of insulin release (08:55) — Which fats are good and bad for you? (13:22) — How dietary fat affects your glucose response (14:59) — The importance of fiber (15:52) —What does fiber do? ⁠⁠⁠Transcript & Show notes⁠⁠⁠ 🔗 LINKS: Watch the full library for Rob’s Ultimate Health Guide: https://www.youtube.com/playlist?list=PLt_J9-Sfer-lwssEdcuNTm3mmKhKqgd-z

29 Elo 202436min

#262 - How do lifestyle changes affect your metabolic health? | Dr. Robert Lustig & Ben Grynol

#262 - How do lifestyle changes affect your metabolic health? | Dr. Robert Lustig & Ben Grynol

Exercising and changing your diet are both beneficial for metabolic health. But you may be wondering which one has more benefits for fat loss, increasing insulin sensitivity, and more. Dr. Robert Lustig and Ben Grynol discuss the answer to this burning question and more, including how exercise, saunas, stress, and sleep affect glucose levels. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Robert Lustig, MD, & Ben Grynol discuss: (02:30) — Why do you get a glucose spike when you exercise? (04:22) — The sport drink industry puts fructose in its products (05:27) — What happens to your glucose when you enter a sauna? (06:26) — Is it better to exercise or change your diet? (08:16) — How cortisol, the stress hormone, impacts blood sugar and health (10:36) — How does sleep affect your metabolic health? (12:22) — How do you fix sleep deprivation? ⁠⁠Transcript & Show notes⁠⁠ 🔗 LINKS: Watch the full library for Rob’s Ultimate Health Guide: ⁠⁠https://youtu.be/zG4XD116uy8?si=TesKp1WkgmgdrEay

15 Elo 202416min

#261 - Uric acid-raising foods to avoid for metabolic, gut, and overall health | Dr. David Perlmutter & Dr. Casey Means

#261 - Uric acid-raising foods to avoid for metabolic, gut, and overall health | Dr. David Perlmutter & Dr. Casey Means

High uric acid can cause gout, but it’s also a marker for worsened metabolic health and gut health and a contributor to neurodegenerative diseases, such as Alzheimer’s. Consumption of purines can lead to high uric acid levels, but other ingredients in our food system are also culprits. Dr. David Perlmutter and Dr. Casey Means discuss the problems with high uric acid, the foods and drinks that can lead to higher levels, why uric acid can be a driver of worsened brain health, and concerns regarding leaky gut and the immune system. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What David Perlmutter, MD, & Casey Means, MD, discuss: (04:36) — Why your uric acid level matters for metabolic health (08:51) — Fructose is a driver of high uric acid levels (13:55) — High-fructose corn syrup contributes to the obesity epidemic (15:57) — The key difference between fruit and fruit juice (25:42) — What is an optimal uric acid level? (28:57) — Alcohol consumption contributes to higher uric acid levels (32:32) — Ultra-processed foods contribute to higher uric acid levels (41:13) — Gut permeability can challenge the immune system (52:43) — Immunometabolism is the link between our metabolism and immune system (59:26) — What causes immune cells in the brain to become dysfunctional? ⁠⁠Transcript & Show notes⁠⁠ 🔗 LINKS: Watch the conversation: https://youtu.be/IZhi4JXxy6Y

1 Elo 20241h 9min

#260 - Why high insulin levels drive fat storage and weight gain and what you can do | Dr. Robert Lustig & Ben Grynol

#260 - Why high insulin levels drive fat storage and weight gain and what you can do | Dr. Robert Lustig & Ben Grynol

High insulin levels drive the growth of fat cells. In turn, fat gain can exacerbate insulin resistance, leading to a vicious cycle. Insulin is a hormone the pancreas releases in response to glucose rising in the bloodstream. A lower insulin level is required to lose fat, and dietary habits and lifestyle changes can help. Dr. Robert Lustig and Ben Grynol discuss insulin’s dual functions in the body, why high insulin leads to fat storage, and how to lower insulin levels. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Robert Lustig, MD, & Ben Grynol discuss: (03:05) — What drives fat growth? (04:17) — Why insulin is both good and bad (08:25) — Why insulin resistance creates a vicious cycle of fat gain (10:36) — Changing diet is the easiest way to lower insulin levels to drive fat loss ⁠Transcript & Show notes⁠ 🔗 LINKS: Watch the full library for Rob’s Ultimate Health Guide: ⁠https://youtu.be/zG4XD116uy8?si=TesKp1WkgmgdrEay

11 Heinä 202412min

#259 - What being ‘postdiabetic,’ rather than prediabetic, means and how to get there | Eric Edmeades & Ben Grynol

#259 - What being ‘postdiabetic,’ rather than prediabetic, means and how to get there | Eric Edmeades & Ben Grynol

Before someone develops type 2 diabetes, they go through a prediabetic stage. But if someone is reversing their diabetes and is trending toward better glucose levels or even optimal levels, they are postdiabetic. Eric Edmeades and Ben Grynol discuss Edmeades’s new book “Postdiabetic,” his company Wildfit, and how the program helps people reverse type 2 diabetes, change their relationship with food, and overhaul their health. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Eric Edmeades & Ben Grynol discuss: (04:42) — The makings of the obesity epidemic (13:46) — Switching between fuel sources (20:09) — The high cost and consequences of type 2 diabetes (24:19) — Eric Edmeades explains the health experiment that changed his life (27:29) — Doctors aren’t taught much about nutrition in medical school (33:35) — Why doctors may be more likely to prescribe medicine than preventions (34:58) — Wildfit helps people change their relationship with food and reverse type 2 diabetes (40:49) — Why Edmeades titled his book “Postdiabetic” (59:44) — The culpability of the food industry and the government (55:38) — Diets are not the answer (58:54) — Fat as a nutrient is not the enemy ⁠Transcript & Show notes⁠ 🔗 LINKS: Watch the conversation: https://youtu.be/QO4X6ePQZi8?si=LulpiRMkuWVV4dLj

4 Heinä 20241h 1min

#258 - What are glucose and insulin and why do they matter for health? | Dr. Robert Lustig & Ben Grynol

#258 - What are glucose and insulin and why do they matter for health? | Dr. Robert Lustig & Ben Grynol

Excess glucose from food gets stored as fat. And our insulin response drives that fat storage. The goal is for the pancreas to release less insulin but for the body to have a healthy response to it. Dr. Robert Lustig and Ben Grynol discuss the interplay between glucose and insulin, healthy glucose numbers, and the problems with insulin resistance. Sign Up to Get Your Free Ultimate Guide to Glucose: ⁠⁠⁠⁠⁠⁠https://levels.link/wnl⁠⁠⁠⁠⁠⁠ Levels helps you see how food affects your health, empowering you with the tools needed to achieve health goals and improve healthspan. Levels Members gain access to the Levels app and continuous glucose monitors (CGMs), providing real-time feedback on how diet and lifestyle choices impact your metabolic health. Look for new shows every month on A Whole New Level, where we have in-depth conversations with thought leaders about metabolic health. 🎙 What Robert Lustig, MD, & Ben Grynol discuss: (03:10) — The functions of glucose (04:24) — Glucose levels change throughout the day (05:30) — The implications of reactive hypoglycemia (08:51) — Understanding glycemic index and glycemic load (11:12) — How many glucose spikes per day are okay? (14:34) — Insulin drives fat storage (17:41) — How glucose spikes do their damage (19:03) — How eating late before bed can cause insulin resistance (22:12) — A look at healthy glucose levels (27:06)  — Insulin resistance is the first sign of issues Transcript & Show notes 🔗 LINKS: Watch the full library for Rob’s Ultimate Health Guide: https://youtu.be/zG4XD116uy8?si=TesKp1WkgmgdrEay

20 Kesä 202432min

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