Nature Podcast1 Loka 2025

Ancient viral DNA helps human embryos develop

00:50 How ancient viruses drive modern human development

Research suggests that ancient viral-DNA embedded in the human genome is playing a key role in early embryo development. Around 8% of our genome consists of endogenous retrovirus DNA — the remnants of ancient infections, but knowledge of their activity is limited. Now, a team show that these sequences are required for the correct development of lab-derived embryo analogues, and for the switching on of human-specific genes.

Research Article: Fueyo et al.

News and Views: Ancient viral DNA in the human genome shapes early development

10:39 Research Highlights

Longer whale mothers are more likely to give birth to daughters — plus, how the stink of the corpse flower waxes and wanes to attract pollinators.

Research Highlight: Big mother whales have more daughters than sons

Research Highlight: Corpse flowers waft out stinky compounds as fast as landfills do

13:05 How heat can fuel DNA computers

Researchers have developed a way to use heat to recharge DNA-based computer circuits, which could help overcome one of the stumbling blocks preventing this technology from being scaled up. Although DNA strands have been used to perform computational tasks for some time, current methods can run out of energy or build up waste products, preventing their continued use. Now, using just heat a team have demonstrated a reuseable neural network based on DNA. They hope that ultimately this could be a step in the development of bigger and more powerful DNA computers that could be used to power targeted clinical therapies.

Research Article: Song & Qian

22:20 Briefing Chat

A one-time gene therapy for Huntington’s disease show promise at slowing the brain disorder’s progression — plus, how mitochondria throw out ‘tainted’ DNA.

Nature: Huntington’s disease treated for first time using gene therapy

Nature: Mitochondria expel tainted DNA — spurring age-related inflammation

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Briefing Chat: How Dolly Parton left her mark on science

In this episode:00:18 Researchers celebrate Dolly Parton's contributions to scienceNature: Dolly Parton dies aged 80 — researchers celebrate her contributions to science08:40 Phase III trial of melano...

28 Elo 14min

Highest-ever ocean temperatures recorded as El Niño intensifies

Why extreme temperatures are expected to weaken ocean carbon sinks — plus, how mitochondrial injections could treat vision loss.00:46 The world’s oceans reach a record temperatureNature: Ocean tempera...

26 Elo 19min

Briefing Chat: New narcolepsy drug could unlock host of novel brain therapies

Nature staff discuss how an FDA-approved drug for narcolepsy could have promise beyond the condition, and the longest-lived human brain organoids yet.00:28 The promise of a new narcolepsy drugNature: ...

21 Elo 12min

A black hole's spin could finally be measured by a high-speed star

Star orbiting close to Sagittarius A* could reveal its spin — plus, how exoskeletons might change the way humans move.00:46 The star that could reveal a black hole’s spinResearch article: Dayem et al....

19 Elo 29min

Briefing Chat: Anthropic rolls out new AI watermark — will it make a difference?

In this episode:00:29 What does Anthropic’s new watermark mean for research?Nature: Can Anthropic’s invisible watermarks curb ‘AI slop’? Researchers remain sceptical10:57 Ticklishness is a distinct, s...

14 Elo 16min

The probiotic bacteria engineered to treat diabetes

Genetically modified bacteria lower high blood-sugar in animal trials — plus, how to safely watch a solar eclipse.00:45 A living diabetes treatmentResearch article: Guan et al.08:03 Research Highlight...

12 Elo 19min

Briefing Chat: Is DNA repair the secret to a long life? Whales and mole-rats offer tantalizing hints

Nature staff discuss how animal studies are starting to uncover how DNA repair could prolong life, and how COVID-19 can reawaken dormant viruses.00:25 Could reawakened viruses have a link to long-COVI...

7 Elo 13min

Junk plastic turns into high-value commodity with chemistry trick

Researchers untangle the chemistry behind turning PVC into high-grade motor lubricant — plus, how engineered yeast can help make a cancer drug.00:45 The chemistry behind converting PVC into lubricantR...

5 Elo 13min