TWiV 972: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the infectiousness of SARS-CoV-2 breakthrough infections and reinfections during the Omicron wave, virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants, antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants, comparative effectiveness of third doses of mRNA-based COVID-19 vaccines in US veterans, time to negative PCR conversion among high-risk patients with mild-to-moderate Omicron BA.1 and BA.2 COVID-19 treated by Sotrovimab or Nirmatrelvir, COVID drug Paxlovid was hailed as a game-changer, what happened?, the Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice, SARS-CoV-2 infection and persistence in the human body and brain at autopsy, long-term cardiovascular outcomes of COVID-19, and how heart-disease risk soars after COVID — even with a mild case.

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Links for this episode

• Infectiousness of breakthrough infections & reinfections during Omicron wave (Nature)
• Virological characteristics of the SARS-CoV-2 XBB variant (bioRxiv)
• Antibody evasion properties of BQ and XBB subvariants (Cell)
• Comparative effectiveness of third doses of mRNA vaccines in US veterans (Nature)
• Time to negative PCR conversion among high-risk patients treated by Sotrovimab or Nirmatrelvir (CMI)
• Paxlovid patient eligbiliity screening checklist (FDA)
• COVID drug Paxlovid was hailed as a game-changer. What happened? (Nature)
• Fc-effector function of COVID-19 convalescent plasma contributes to treatment efficacy (Cell)
• SARS-CoV-2 infection and persistence in the human body and brain at autopsy (Nature)
• Long-term cardiovascular outcomes of COVID-19 (Nature)
• Heart-disease risk soars after COVID (Nature)
• Contribute to our MicrobeTV fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 972
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv