TWiV 986: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the efficacy and safety of two RSV vaccines in older adults, health care vaccine mandate remains as some push for an end, past SARS-CoV-2 infection protection against re-infection, a third vaccine dose equalizes the levels of effectiveness and immunogenicity of heterologous or homologous COVID-19 vaccine regimens, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, effect of higher-dose Ivermectin for 6 Days vs placebo on time to sustained recovery in outpatients with COVID-19, viral burden rebound in hospitalized patients with COVID-19 receiving oral antivirals in Hong Kong, serological response to vaccination in post-acute sequelae of COVID, sex differences in cardiovascular complications and mortality in hospital patients with COVID-19, association of COVID-19 vaccination with risk for incident diabetes after COVID-19, postacute sequelae of SARS-CoV-2 in university setting, the CDC's long-Covid deception, and podcast companies, once walking on air, feel the strain of gravity.

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Links for this episode

• RSV prefusion F protein vaccine in older adults (NEJM)
• Efficacy and safety of an Ad26.RSV.preF–RSV preF protein vaccine (NEJM)
• Health care vaccine mandate remains as some push for an end (AP)
• Past SARS-CoV-2 infection protection against re-infection (The Lancet)
• A third vaccine dose equalizes the levels of effectiveness and immunogenicity of COVID-19 vaccine regimens (medRxiv)
• Sotrovimab retains activity against SARS-CoV-2 Omicron variant in primate model (bioRxiv)
• Effect of higher-dose Ivermectin for 6 days vs placebo in patients with COVID-19 (JAMA)
• Viral burden rebound in patients with COVID-19 receiving oral antivirals (The Lancet)
• Serological response to vaccination in post-acute sequelae of COVID (BMC)
• Sex differences in cardiovascular complications and mortality in patients with COVID-19 (BMI)
• Association of COVID-19 vaccination with risk for incident diabetes after COVID-19 (JAMA)
• Postacute sequelae of SARS-CoV-2 in university setting (CDC)
• The CDC's Long-Covid deception (WSJ)
• Podcast companies, once walking on air, feel the strain of gravity (NYT)
• Contribute to our ASTMH fundraiser at PWB
• Dr. Griffin's treatment guide (pdf)
• Letters read on TWiV 986
• Don't crush Paxlovid (pdf)
• Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv