#473 Tech Expert: Why Life Speeds Up As You Age (And How To Slow It Down!)

Get my 2025 supplement guide: https://www.siimland.co/supplement-list-2025Timestamps:00:00 Intro00:14 Taurine01:19 Apigenin01:55 Resveratrol03:20 Rapamycin04:55 Metformin06:11 Calcium AKG07:30 Melatonin08:16 SIRT609:05 NAC09:43 NMN, NR, Niacinamide11:10 Niacin13:58 Glycine15:16 Spermidine16:44 Omega-3s17:40 Creatine18:48 Pterostilbene19:19 Magnesium20:16 Vitamin K220:45 Sulforaphane21:34 Curcumin22:08 Methylated B vitamins22:33 Glutathione24:08 Lithium24:55 Lutein & Zeaxanthin25:30 Vitamin C26:29 Ergothioneine27:23 Methylene blue28:46 Multivitamin29:37 Aged garlic extract30:22 Astaxanthin31:06 TMG31:50 Ginger32:15 CoQ1032:53 PQQ33:24 Chondroitin33:45 MSM32:25 Glucosamine34:54 Conclusion100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmAJoin our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/

10 Loka 37min

Josh Witteldorf is a PhD in physics who pivoted to researching aging and investigated the evolutionary reasons for aging and human lifespan. He's written the book Cracking the Aging Code.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:30 How Josh, as a physicist, got into aging research04:35 Why aging is an evolutionary program13:50 Why humans die and age20:45 Bon Charge sponsorship21:35 Why did aging evolve as an adaptation24:40 Species that are biologically immortal30:25 Shocking way group selection selects for aging and death33:55 How predator-prey relations select for aging43:15 Can humans control our own evolution48:15 A long-term human calorie restriction experiment in Biosphere 252:50 Insulin’s effects on aging 55:20 mTOR and aging57:15 Can you deprogram aging and extend lifespan01:10:00 Gene editing01:15:15 Josh’s predictions for the futureJosh Mitteldorf blog: https://scienceblog.com/joshmitteldorf/ Josh's book Cracking the Aging Code: https://amzn.to/4mFmC6mStart rewinding your biological clock: https://www.siimland.co/course

26 Syys 1h 20min

Get my free bloodwork cheat sheet: https://www.siimland.co/bloodwork-cheat-sheetTimestamps:00:00 Intro00:32 Resting heart rate02:27 hsCRP03:32 VLDL03:52 LDL particle count04:31 Homocysteine 05:26 Respiratory rate06:30 VO2 max07:36 Body fat percentage09:18 BMI11:57 HRV14:14 Waist circumference and waist to hip ratio16:00 Visceral fat mass and liver fat18:42 White blood cells20:35 Albumin21:11 Muscle mass22:40 Grip strength24:15 Appendicular lean mass index25:31 Creatinine27:55 eGFR29:20 Cystatin C29:32 Biological age tests31:45 Speed of aging test32:45 Phenoage34:25 Bone density36:00 Lung force36:59 Lp(a)38:15 Oxidized LDL39:00 Testosterone43:40 SHBG45:22 Estradiol (E2)46:42 Resting metabolic rate49:00 Body temperature51:48 Liver enzymes (ALT, AST, GGT, ALP)53:14 ApoB55:10 IGF-157:30 ApoA59:30 Calcium score in the arteries (CAC)01:00:46 Carotid intima media thickness (CIMT)01:03:18 Iodine01:05:09 Thyroid hormones (T3 and T4)01:08:00 Progesterone and pregnenolone01:08:51 Thyroid-stimulating hormone (TSH)01:09:47 BNP (cardiac stress)01:10:22 Hemoglobin01:11:22 Iron and ferritin01:12:56 Uric acid01:13:49 HDL cholesterol01:14:53 HbA1c01:15:39 Fasting insulin01:15:58 Fasting glucose01:17:23 Fructosamine01:18:11 Triglycerides01:19:07 Omega-3 index01:20:26 Omega-6-to-3 ratio01:21:01 Red cell distribution width (RDW)01:21:22 Platelets01:22:22 Mean corpuscular volume (MCV)01:22:39 LDL cholesterol01:23:18 Mean corpuscular hemoglobin (MCH)01:23:33 Blood urea nitrogen (BUN)01:23:57 DHEA-S01:24:52 Vitamin D01:26:07 HOMA-IR01:26:26 Red blood cells01:26:38 Hematocrit01:27:01 Erythrocyte sedimentation rate (ESR)01:27:38 LP-PLA201:28:15 Electrolytes01:29:09 Total cholesterol01:29:23 B vitamins01:30:29 Total iron binding capacity (TIBC) and transferrin saturation01:31:00 Heavy metals01:32:48 Microplastics01:34:54 Cortisol01:36:10 TNF-alpha01:36:50 How much can you lift?01:39:22 Cooper test01:40:25 Microbiome diversity01:42:08 Conclusion100 supplements ranked worst to best: https://youtu.be/W8DZbYyuDmA

20 Syys 1h 43min

Greg Potter, PhD, is a circadian rhythm and time-restricted eating expert who researches sleep, circadian rhythms, and time-restricted eatingCheck out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro01:05 Circadian clock dysfunction and hallmarks of aging10:35 How the circadian clocks affect aging and lifespan17:00 Bon Charge sponsorship17:55 Why clock dysfunction contributes to aging24:50 What causes circadian clock dysfunction30:00 NAD metabolism and clock function31:30 Calorie restriction and meal timing36:00 Night owls vs morning larks39:35 Shift work42:18 Melatonin supplementation46:00 Clock enhancing nutraceuticals49:10 Should you supplement melatonin at old age59:45 Morning cortisol circadian rhythm01:04:50 Sunlight and UV & infrared light exposure01:09:05 How to keep your circadian clock system working well during agingGreg Potter YouTube channel: https://www.youtube.com/@gregpotterphd Greg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/Exercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUULongevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQ

12 Syys 1h 14min

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:22 Dr Robbins background in longevity research01:57 What is cell senescence07:52 Benefits of senescent cells early in life09:07 Does eliminating senescent cells increase lifespan14:50 How to eliminate senescent cells17:35 Most researched senolytics22:15 Can you reverse the age of senescent cells24:00 Immune system and aging26:20 Rapamycin29:20 Practical tips to reduce your senescent cell burden33:50 Are GLP-1 receptor agonists anti-aging drugs36:55 Should people take senolytics41:05 Gene therapies for senescent cells50:45 What things need to be focused on for breakthroughs in longevity researchDr. Robbins is a Professor of Biochemistry, Molecular Biology and Biophysics and Associate Director of the Masonic Institute on the Biology of Aging and Metabolism (MIBAM) and the Medical Discovery Team on the Biology of Aging at the University of Minnesota. Paul Robbins Research lab: https://robbins.umn.edu/Full routine to go from average to top 1% health: https://youtu.be/dHfhTQSBAfg➡ Join our LONGEVITY and ANTI-AGING Skool Community: https://www.skool.com/youthspan-society-9710/Start rewinding your biological clock: https://www.siimland.co/course

5 Syys 1h

Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:20 Greg and Siim's background06:35 Our opinion on what’s the best diet12:50 What is most important: how much you eat, what you eat, when you eat18:15 Bon Charge sponsorship19:05 How important is the timing of when you eat42:30 Best diet for top 1% longevity, top 1% athletics and general wellbeing53:00 How to structure your calories, protein, carbs and fats01:07:15 Better and worse forms of protein, carbs and fats01:30:20 Low protein vs high protein for longevity02:09:25 Low carb vs plant-based diet02:10:00 Diet tribalism on social media02:33:00 Final wordsExercise roundtable with Greg and Nic: https://youtu.be/8eW5gNiSxUULongevity supplement roundtable with Greg and Nic: https://youtu.be/OBPacg_tVuQGreg Potter YouTube channel: https://www.youtube.com/@gregpotterphdGreg Potter PhD Instagram: https://www.instagram.com/gregpotterphd/Physionic Instagram: https://www.instagram.com/physionic_phd/Physionic YouTube channel: https://www.youtube.com/@PhysionicStart rewinding your biological clock: https://www.siimland.co/courseP.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

29 Elo 2h 36min

Get your free personalized health review: https://www.siimland.co/reviewTimestamps:00:00 Intro01:10 Summary of our biomarker differences02:30 Fitness markers09:45 Body composition markers14:45 Inflammation and immune markers19:30 Metabolic health markers24:15 Cardiovascular markers36:30 Kidney markers43:45 Liver markers47:00 Hormone markers53:20 Experimental longevity tests56:45 PhenoAge biological age test01:01:40 RecapMy Evidence-Based Longevity Routine: https://youtu.be/4xkRcfeGDooStart rewinding your biological clock: https://www.siimland.co/course

23 Elo 1h 3min