Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1415)

Max Lugavere: Dementia, Aerobic Exercise & Filming Bread Head - #229

Max Lugavere: Dementia, Aerobic Exercise & Filming Bread Head - #229

Why you should listen –  Max Lugavere comes on Bulletproof Radio today to discuss his upcoming documentary Bread Head, preventing cognitive decline, early stages of Alzheimer’s and dementia, and the effects of gluten on our brains.  Enjoy the show! Max Lugavere is a multi-hyphenate filmmaker and media personality. He is the director, writer, and narrator of BREAD HEAD, a documentary exploring the impact of diet and lifestyle on brain health. Max has written about science, technology and health innovation for The Daily Beast, Fast Company, Huffington Post, and Psychology Today. Max created and hosted Acting Disruptive, AOL’s top viewed web series ever. He was also the host and producer of Al Gore’s Emmy-winning Current TV. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Kesä 20151h 4min

Dr. Joseph Mercola: Roundup, Aspartame & Intermittent Fasting - #228

Dr. Joseph Mercola: Roundup, Aspartame & Intermittent Fasting - #228

Why you should listen –  Dr. Joseph Mercola comes on Bulletproof Radio today to discuss how sitting down harms us, why you should intermittently fast and, the truth about Aspartame and Roundup.   Dr. Mercola is a well-known osteopathic physician (DO) and a three-time New York Times Bestselling author. He is the founder of Mercola.com, which is the #1 Natural Health site on the Internet with over one million subscribers. Dr. Mercola was named the top Ultimate Wellness Game Changer by the Huffington Post in 2009. He has been featured in various media outlets such as TIME magazine, LA Times, ABC News, CNN, Fox News, Today Show, Dr. Oz, Forbes Magazine and others. His primary passion is transforming the conventional medical paradigm in the United States. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Kesä 201558min

Dr. Daniel Amen: Alzheimer’s, Brain Food & SPECT Scans - #227

Dr. Daniel Amen: Alzheimer’s, Brain Food & SPECT Scans - #227

Why you should listen –  Dr. Amen comes on Bulletproof Radio today to discuss healing toxic brains, Alzheimer’s and dementia, and how SPECT scans can upgrade your life. Enjoy the show! Dr. Daniel Amen is a physician, double board certified psychiatrist, nine-time New York Times bestselling author, Founder and CEO of Amen Clinics.  He has written, produced and hosted 9 popular shows about the brain that have aired over 70,000 times across North America and have raised more than $52 million dollars for public television.  His work has been featured in Newsweek, Time, Huffington Post, ABC World News, 20/20, BBC, London Telegraph, Parade Magazine, Washington Post, LA Times, Men’s Health, Bottom Line, and Cosmopolitan. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Kesä 201558min

Jake Ducey: Public Speaking, Travelling & Dropping Out of College - #226

Jake Ducey: Public Speaking, Travelling & Dropping Out of College - #226

Why you should listen –  Jake Ducey comes on Bulletproof Radio today to discuss becoming a writer, dropping out of school, traveling the world, and the art of public speaking. Enjoy the show! Jake Ducey is an author and speaker at 19 he independently released his first book, “Into the Wind,” about quitting college basketball to travel the world. Ducey then became the youngest motivational author to sign a book deal with Penguin/Random-House for his second book, “The Purpose Principles.” This spring he will embark on one of the largest book tours ever which will be filmed and produced into a major documentary about his generation. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Kesä 201546min

Emily Fletcher: Ziva Meditation, Improving Sleep & Better Sex - #224

Emily Fletcher: Ziva Meditation, Improving Sleep & Better Sex - #224

Why you should listen –  Emily Fletcher comes on Bulletproof Radio today to discuss online meditation, how the right and left brain work, the “balancing breath” technique, and meditating for better sex. Enjoy the show! Emily Fletcher is the founder of Ziva Meditation and the creator of zivaMIND, the first online meditation training program. She began her meditation training in Rishikesh, India and was inspired to become a meditation teacher after experiencing the profound physical and mental benefits it provided her during her 10-year career on Broadway.  She has taught at Google, Harvard Business School, Viacom, and Summit Series.  She has also been featured in The New York Times, Huff Post LIVE and Mind Body Green. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Kesä 20151h 7min

Gary Taubes: Bad Science, Gut Health, & NuSi - #223

Gary Taubes: Bad Science, Gut Health, & NuSi - #223

Gary comes on Bulletproof Radio to discuss the bad science in public health, researching healthy diets, the role of gut bacteria in obesity, and self experimentation. Enjoy the show! Gary Taubes is an American science writer. He is the author of Good Calories, Bad Calories which is titled The Diet Delusion in the UK and Why We Get Fat. He has won the Science in Society Award of the National Association of Science Writers three times and was awarded an MIT Knight Science Journalism Fellowship for 1996-97. He is also a co-founder of Nutrition Science Initiative. NuSI’s mission is reduce the individual, social, and economic costs of obesity, diabetes, and their related diseases by improving the quality of science in nutrition and obesity research. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Touko 201559min

Dr. John Gray: Addiction, Sexuality, & ADD  - #222

Dr. John Gray: Addiction, Sexuality, & ADD - #222

Best selling author of the wildly successful book, Men are from Mars, Women are from Venus, John Gray comes on Bulletproof Radio to discuss causes and natural remedies for ADD, flow states and addiction, gender differences in relationships, and Taoist principles of sexuality. Enjoy the show! John Gray is the best-selling relationship author of all time and the most trusted voice in relationships today. He is the author of 17 books, including The New York Times # Best-Selling Book, Men Are From Mars, Women Are From Venus. His books have sold over 50 million copies in 50 different languages around the world. For more than 35 years he has conducted public and private seminars for thousands of participants. He is a popular speaker and has appeared on Oprah, The Dr. Oz Show, Good Morning America, The Today Show, The CBS Morning Show, Live with Regis, Larry King Live, CNN and many others. John’s purpose is to create a world where men and women understand, respect, and appreciate their differences and ultimately work together. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Touko 20151h 7min

Bulletproof Radio Short Report - Moldy - #221

Bulletproof Radio Short Report - Moldy - #221

Why you should listen -  The Bulletproof Radio Short Report is a highly condensed show to quickly bring you the most important ways to upgrade yourself and kick ass at life. Enjoy the show! Todays episode was shot during PaleoF(x), one of the largest Paleo conferences in the country, where I had the privilege to give a keynote address. Today’s short report is about my upcoming Moldy documentary, mold toxins in our coffee, and how mold exposure makes you weak, sick, and fat.   See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Touko 201512min

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