Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1414)

A Second Opinion: Laetrile at Sloan-Kettering with Ralph Moss & Eric Merola – #155

A Second Opinion: Laetrile at Sloan-Kettering with Ralph Moss & Eric Merola – #155

The documentary, A Second Opinion, is debuting at Seattle’s AMC Pacific Place 11 this weekend, Fri-Sun 9/19 – 9/21, and Eric & Ralph will be hosting live Q&As there all weekend. If all shows are sold out for the weekend, AMC will take the film nationwide, so this is a make-or-break opening weekend. If you live in the Seattle area, please go see the movie this weekend! Eric and Ralph will give anyone who mentions that they heard of the film on Bulletproof Radio a free, signed copy of the DVD (with TONS of bonus materials), and admission to the live Q&A’s is free with a ticket stub from the movie theater for the documentary.   A Second Opinion is a documentary by award-winning filmmaker, Eric Merola, about Ralph Moss and his whistleblowing on a massive cover-up involving the unconventional cancer therapy Laetrile at Sloan-Kettering Institute for Cancer Research. Eric has worked for Fuel TV and the WE Network, worked with Michael Moore on the documentary “Capitalism: A Love Story”, and his documentary BURZYNSKI has garnered widespread distribution and numerous international awards. Ralph has written more than 15 books on cancer research, and has received lifetime achievement awards from the American College for the Advancement of Medicine, the Cancer Control Society, The National Foundation for Alternative Medicine, and many other organizations in the cancer education and alternative medicine industries.   Why you should listen –     Laetrile is a natural compound that research showed stopped the growth and spread of cancer, and the info Ralph has to share is shocking for anyone that has ever had their lives touched by cancer. Ralph and Eric discuss the history of the Laetrile cancer treatment, why it was rejected and renounced, and also touch on other exciting new breakthroughs in cancer therapy that people should be aware of. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Syys 201459min

Hacking Trauma, Fear, & Greatness with Lewis Howes – #154

Hacking Trauma, Fear, & Greatness with Lewis Howes – #154

Lewis Howes is an entrepreneur, investor, and athlete. Lewis runs a multi-million dollar online media company, and is the creator of the acclaimed podcast, The School of Greatness, a show that aims to help people find their own path to success. He is a former professional football player, two-sport collegiate All-American, a World Record holding athlete, and currently on the USA Men’s National Team For the Olympic Sport, Team Handball. Howes was recently recognized by Details Magazine as one of the “5 Internet Gurus Who Can Make You Rich”, and awarded as one of the top 100 entrepreneurs in the country under 30 by Empact100 and the White House!   Why you should listen –     Lewis comes on Bulletproof Radio to discuss overcoming adversity, trauma, and fears, how to hack flow states, and the keys to success and achieving greatness in all aspects of your life. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Syys 201456min

David Epstein on the Sports Gene & the Science of Extraordinary Performance – #153

David Epstein on the Sports Gene & the Science of Extraordinary Performance – #153

David is the author of The Sports Gene, a book that explores the complex factors that make up a championship athlete. David is an award-winning investigative reporter for ProPublica and Sports Illustrated, focusing on hard-hitting pieces about sports science, medicine, and Olympic sports. He co-authored reports, breaking the Alex Rodriguez doping and Jim Tressel NCAA violations scandals, and is one of the foremost experts on the different factors that impact sports performance.   Why you should listen –     David comes on Bulletproof Radio to talk about hacking expertise, the impact of genetics, doping, and diet in sports performance, whether or not the 10,000 hour rule is legit, and if athletes are really getting better, faster, and stronger. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Syys 20141h 1min

Bulletproof Radio Short Report: Biohacking Tech for Deeper Sleep & Boosting Relaxation – #152

Bulletproof Radio Short Report: Biohacking Tech for Deeper Sleep & Boosting Relaxation – #152

The Bulletproof Radio Short Report is a highly condensed show to quickly bring you the most important ways to upgrade yourself and kick ass at life. This week is about hacking your sleep and energy levels with the Sleep Induction Mat. In this episode, you’ll hear about the benefits of the ancient art of acupressure, how to manipulate your nervous system to maximize relaxation, and how to upgrade your feet and skin (not just your sleep!) with the mat. Enjoy!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Syys 20146min

Uncovering the Science of MCTs & Bulletproofing Your Pets with Melinda Culver – #151

Uncovering the Science of MCTs & Bulletproofing Your Pets with Melinda Culver – #151

Melinda Culver is a veterinarian with a PhD in Animal Sciences from Washington State University. She works for ABITEC, a company that specializes in ester chemistry emulating products found in nature to produce high-quality pharmaceuticals, nutritional supplements, and personal care products, and acts as an advisor to the Horn School for Animal Wellness. Melinda did her dissertation on “The Growth and Development of Muscle and Fat Cells”, and has authored or co-authored over 30 publications, including extensive work using MCT Oil to craft a healthy diet for animals. Why you should listen – This episode is a must-listen for any animal lover! Melinda comes on the show to talk about the science of Medium Chain Triglycerides (MCTs), the optimal diet for your pets, the benefits of MCTs and ketones for animals, and to give a quick lesson on how fats are digested in the body. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Syys 201449min

The Art of Charm on Upgrading Confidence & Enhancing Relationships – #150

The Art of Charm on Upgrading Confidence & Enhancing Relationships – #150

Jordan Harbinger is the co-founder of the wildly popular website where ordinary guys become extraordinary men: The Art of Charm. Jordan is a former lawyer turned relationship coach, and is now the co-host of the Art of Charm Podcast, a top-rated show on iTunes. He has been featured on NBC’s Today Show, in Men’s Health, Cosmopolitan, and Details Magazines, The Huffington Post, and even in Psychology Today. The goal of the Art of Charm is to teach men (and women!) how to take control of their physiology and use better social skills to kick more ass in their relationships, in business, and in life.   Why you should listen –    Jordan comes on the show to talk about why confidence is a skill that can be learned, how to hack your networking & social skills, about the power of good feedback, and why upgrading your communication is important for ALL relationships. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

3 Syys 20141h 3min

Nina Teicholz on Saturated Fats & the Soft Science of Fat - #149

Nina Teicholz on Saturated Fats & the Soft Science of Fat - #149

Nina Teicholz is an investigative journalist and author of the New York Times Best-Selling Book, The Big Fat Surprise: Why Butter, Meat and Cheese Belong in a Healthy Diet. She is a well-respected food and nutrition writer that has contributed to publications such as the New York Times, the New Yorker, the Economist, and Men’s Health Magazines, and is a former NPR reporter and associate director for the Center of Globalization and Sustainable Development at Columbia University. Why you should listen - Nina comes on Bulletproof Radio to talk about her book, The Big Fat Surprise, discussing: the truth about saturated fats and their health benefits, a story of failed science and fat, the dangers of oxidized oils, and why our working hypothesis of health isn’t working. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Elo 201458min

Bulletproof Radio Q&A #148 – Podcast

Bulletproof Radio Q&A #148 – Podcast

On this episode of Bulletproof Radio, we have carefully selected the best questions from Facebook, Twitter, and the Bulletproof® Forums for another awesome Q&A! Thanks to you, the listener! Hear a thought-provoking conversation and gain a ton of useful knowledge in this episode about the art of biohacking, nutrition, and… well… kicking ass at life in general! Dave and Zak talk about Bulletproof personal care products, whether or not to use supplements with kids, and even demonstrate how to make Bulletproof® Coffee while you’re on-the-go! Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Elo 201447min

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