Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1413)

#112 AJ Jacobs on His Life as an Experiment

#112 AJ Jacobs on His Life as an Experiment

Bestselling author and renowned NYC journalist, AJ Jacobs is a living, breathing experiment. On this episode of Bulletproof Radio, AJ reveals his methods behind hacking into (what he calls) the three domains of self-improvement. Jacobs talks about his quest to become the smartest person, what happened when he lived (quite literally) according to the Bible, and his humble quest for bodily perfection. Also catch tips on how to act your way into a new way of thinking. Enjoy!     A.J. Jacobs is an author, journalist, lecturer and human guinea pig. He has written four New York Times bestsellers that combine memoir, science, humor and a dash of self-help. He is also editor at large at Esquire magazine, a commentator on NPR and a columnist for Mental Floss magazine. His first book is called The Know-It-All: One Man’s Humble Quest to Become the Smartest Person in the World (Simon & Schuster, 2004). The memoir — which spent two months on the New York Times bestseller list — chronicles the 18 months Jacobs spent reading the entire Encyclopedia Britannica in a quest to learn everything in the world. It was praised by Time magazine, Newsweek, Vanity Fair, USA Today, Janet Maslin in the New York Times and AJ’s uncle Henry on Amazon.com. Follow him on Twitter @ajjacobs! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Huhti 201448min

#111 Olympian Bree Schaaf talks Staying Bulletproof at Sochi

#111 Olympian Bree Schaaf talks Staying Bulletproof at Sochi

Olympian turned NBC analyst, Bree Schaaf talks staying Bulletproof while at the Sochi Olympics last month. Bree has been competing in sliding sports for the past 12 years. Just now back from Russia, Bree’s on Bulletproof Radio to discuss skeleton bobsled racing, her kickass routine for high performance, how she recovered from hip surgery, selenium toxicity, and more. Hear about how she didn’t let even the TSA keep her from eating a Bulletproof Diet during the games.     The former Portland State University Volleyball player spent her first five years on ice as a skeleton athlete before becoming a bobsled pilot.  Schaaf has earned 13 top-10 finishes on the World Cup circuit and finished fifth with brakeman Emily Azevedo at the Vancouver 2010 Olympic Winter Games. Schaaf is the first American female to compete in both a Skeleton World Championships as well as Bobsled World Championships.   Coming up just short at Olympic Trials this year, Schaaf not only be attended the Sochi 2014 Olympics as alternate, but made her NBC Olympics broadcast debut as a skeleton analyst and sliding sports correspondent.     ·           0:10 – Cool Fact of the Day! ·           0:30 – Welcome Bree Schaff ·           1:01 – What is skeleton? ·           3:57 – Traveling to Russia with butter and MCT ·           8:25 – Bree’s routine for high performance ·         10:50 – Hip surgery recovery and Bulletproof ·         14:05 – Finding glutes under the “lady fat” ·         14:35 – Bio-hacking menstrual cycle ·         18:00 – Testosterone envy ·         19:10 – Competitive drive ·         23:30 – Karaoke flow state ·         26:30 – Cholesterol ·         27:00 – Selenium toxicity ·         29:40 – Mental training and meditation   ·         39:05 – Top three recommendations for kicking more ass and being Bulletproof! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Huhti 201445min

#110 CrossFit Master Shana Alverson Makes Strong The New Skinny

#110 CrossFit Master Shana Alverson Makes Strong The New Skinny

One of the 50 fittest women in the world comes on Bulletproof Radio to talk about how strong is the new skinny and how she became a major player in the CrossFit community. On this episode of Bulletproof Radio you’ll get a look inside the mind of a real CrossFit master and she’s sassy too. Alverson talks about her strict adherence to a Paleo diet, her thoughts on women and ketosis, and if she thinks it’s okay to do CrossFit while pregnant. Get the show below!     Shana Alvesrson owns Crossfit East Decatur in Georgia. She is a level 1 Certified CrossFit trainer as well as a Level I CrossFit Running & Endurance Certified. Shana also trains in CrossFit Olympic lifting, movement & mobility, gymnastics, and Crossfit kids. Her passion for the gym began at 15 after discovering how nutrition and exercise elevated her mood. She has been teaching people how to exercise since 1995, and in 2007 began her CrossFit training career. Catch her kicking ass a CrossFit East Decatur and on Twitter @ShanaAlverson. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Huhti 201441min

#109 Steven Kotler and The Rise of Superman

#109 Steven Kotler and The Rise of Superman

Have you ever experienced a flow state? It’s the superhuman state of high performance when everything is in-sync and you’re kicking ass at life? Bestselling author of The Rise of Superman, Steven Kotler, will teach you how to find your flow state and stay there. In this episode of Bulletproof Radio, Kotler breaks down the 3 psychological conditions for flow state, the 4 stages of flow, and how to turn it on and off. Steven also tells a great story about his own flow state experiences as a writer, his battle with Lyme disease, and discusses, The Flow Genome Project.     Steven Kotler is a New York Times bestselling author, award-winning journalist, and co-founder and director of research for the Flow Genome Project. His books include The Rise of Superman, Abundance, A Small, Furry Prayer, West of Jesus, and The Angle Quickest for Flight. His work has been translated into thirty languages and his articles have appeared in more than seventy publications, including the New York Times Magazine, Atlantic Monthly, Wired, and Forbes. You can find him online at stevenkotler.com or writing Far Frontiers, a blog for Forbes.com: www.forbes.com/sites/stevenkotler. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Huhti 20141h

#108 Dr. Sara Gottfried – The Hormone Cure

#108 Dr. Sara Gottfried – The Hormone Cure

Owning your hormonal health is crucial to performance, and this goes for all the sexes. M.D. and bestselling author of “The Hormone Cure,” Dr. Sara Gottfried joins Bulletproof Radio to underscore the importance of leveraging hormones and how to uncover the velvet vulva. Dr. Sara relies on results-based data and her own practice as a physician to define her theory on why women often struggle on high-fat diets and often take a dive off a hormonal cliff. On this show you’ll learn about monitoring your brain chemical three-some, feeding the gut bacteria you want, and how birth control pills can affect sexual attraction.     Dr. Sara Gottfried M.D. is a Harvard-educated physician, speaker, yoga teacher, wife, mom of two daughters, and author of the New York Times bestselling book, The Hormone Cure: Reclaim Balance, Sleep, Sex Drive, and Vitality with The Gottfried Protocol (Simon & Schuster, 2014). She’s also a board-certified gynecologist and the creator of an awesome new online program called Mission Ignition: The Energy Cure. For the past 20 years, Dr. Gottfried has been dedicated to helping women feel back home in their bodies. Like Sara on Facebook! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

28 Maalis 201452min

#107 Pedram Shojai on Vitality and Origins – Podcast

#107 Pedram Shojai on Vitality and Origins – Podcast

“Follow the bread crumbs...”   Many people would say that the human race is entering an era of awakening. Whether that be in mind, body, spirit, or all three there is a good chance that if you’re reading this, you’d agree – or at least you’re interested. Talented physician and documentary filmmaker, Pedram Shojai, is on the show to discuss the concepts behind his two films, Vitality and Origins, and why he’s in the business of waking up zombies. On the show you’ll discover Pedram’s take on what we should be eating, how to make everything you do count the most, and why he’s trying to win the war against healthcare propaganda. Pedram is a great example of how to balance science and mysticism. After all, any good science warrants investigation. Please enjoy!     Pedram Shojai is former Taoist monk and an accomplished physician of Chinese medicine. He is the founder of Well.org, an author, and most recently a documentary filmmaker. After studying biology at UCLA he had a series of profound mystical experiences that drew him to the Eastern esoteric arts. He received a Master’s in Oriental Medicine from Emperor’s College and then his own OMD from the Pan-American University. Pedram has studied Kung Fu, Tai Chi, Qi Gong, Yoga, Meditation, and medicine diligently for the past 20 years, and aims to help people wake up from their zombie haze and live their lives fully. Follow him on Twitter @taoistpath!  See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Maalis 201445min

#106 The Powers of Vitamin K2 with Dr. Kate Rhéaume-Bleue

#106 The Powers of Vitamin K2 with Dr. Kate Rhéaume-Bleue

Knowing your individual vitamin deficiencies is a key part of hacking into high performance. With Vitamin C and D getting so much playtime, it’s easy to overlook other major players like Vitamin K2. The impressive Dr. Kate Rhéaume-Bleue comes on Bulletproof Radio to talk about the powers of Vitamin K2, how you can get more of it in your diet and why you should start today. Ever wondered why you have better dental hygiene, but more cavities than a friend? It turns out that Vitamin K2 plays a major role in dental health, among many other things. This episode will also show you why you may want to start cooking your kale, what gives with the Calcium Paradox, and what exactly is Activator X? Dr. Kate really breaks it down, so you can start hacking into your Vitamin K2 health today.     Kate Rhéaume-Bleue, N.D. graduated from McMaster University with an honors BSc in Biology and completed her professional training at the Canadian College of Naturopathic Medicine in Toronto, class of 2002. She followed with a two-year residency during which she taught classes and supervised at various teaching clinics. As an educator, she regularly appears on television and radio teaching about many health topics. Dr. Kate is a Canadian expert in natural medicine and a contributing editor to several health-related publications. Born and raised on Montreal’s West Island, Kate now makes her home in Ancaster, Ontario (just west of Hamilton) with her husband, sons and Chloe, the Great Dane. Are you taking calcium or vitamin D? This book could save your life!  Learn the secret to avoiding osteoporosis and heart disease with her book, Vitamin K2 and the Calcium Paradox. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

21 Maalis 201451min

#105 Flow State and being a Crossfit Champion with Amanda Allen

#105 Flow State and being a Crossfit Champion with Amanda Allen

Do you own your biology or not? Crossfit Masters Champion, Amanda Allen, certainly does, but it took her a while to get there. On this episode of Bulletproof Radio Amanda talks about her 40-year journey to becoming a mega-athlete and finding her flow state in human performance. Allen talks candidly about her struggles to harness her addictive personality into something positive and what it takes to be a successful female athlete of all types including: her diet regimen, the menstruation effect, and why she has four coaches. Amanda is a true Bulletproof badass. Take a listen!     Amanda Allen is the 2013 Crossfit Games Masters Champion (40-44) and an all around mega-athlete. She found Crossfit when trying to make Worlds in canoeing and after someone told her it would help supplement her abs workout! Before kicking ass at Crossfit, Amanda was a professional Triathlete and Track Cyclist with state, national and world titles in both and even tried her hand at firefighting. She is a Personal Trainer and Lifestyle Coach in Adelaide, Australia, and her dog’s name is Pep. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Maalis 201446min

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