Why Women’s Joints Are Failing 10x Faster : 1349

Why Women’s Joints Are Failing 10x Faster : 1349

Modern joint pain isn’t just wear and tear—it’s a systemic, metabolic disease that starts years before symptoms show. In this episode, you’ll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance.


Watch this episode on YouTube for the full video experience:

https://www.youtube.com/@DaveAspreyBPR


Host Dave Asprey sits down with Kiran Krishnan, an expert microbiologist and advisor to Calroy Health Sciences. He’s the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He’s a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results.


He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You’ll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration.


You’ll learn:

• How cartilage cells (chondrocytes) rely on mitochondria for tissue repair

• Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog

• How cartilage begins to break down in your teens—and what to do about it now

• The surprising clinical data on walking distance, inflammation markers, and recovery

• Why most supplements and NSAIDs fail—and what actually rebuilds joints

• How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal

• The mitochondrial link between joint pain, cardiovascular risk, and depression

• Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it

• How to track your biological joint age using imaging and systemic inflammation labs


This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you’re lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation


**Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave **


Thank you to our sponsors!

-BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.

-BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order.

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order.


Resources:

• Danger Coffee: https://dangercoffee.com/discount/dave15

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com


Timestamps:

0:00 — Trailer

1:25 — Introduction

2:01 — Why Modern Medicine Fails at Joint Pain

3:07 — Painkillers That Accelerate Joint Damage

7:35 — Rheumatoid vs. Osteoarthritis Explained

8:54 — Cytokines That Destroy Cartilage

12:10 — Arthritis Begins in Your Teens

15:35 — 75% Pain Reduction in 7 Days

18:35 — The Science Behind Boswellia & Celery Seed

24:10 — Six-Minute Walk Test Results

25:45 — The $200/Month Painkiller Trap

28:53 — Proof Cartilage Can Regrow

31:01 — Mitochondria and Joint Repair

32:29 — Inflammation Links to Heart Disease

35:52 — Why Glucosamine Doesn’t Work

37:07 — Silent Arthritis in 90% of Adults

40:44 — Why Women Face Higher Joint Risk After 40

45:52 — Food as the #1 Inflammation Trigger

47:23 — Fasting & Cartogenics Stack for Repair

50:27 — Movement Snacks and Efficient Training

55:54 — Why Joints Heal Slower Than Muscles

57:48 — Dave’s Stack and Final Takeaways

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1410)

#66 “The Calorie Myth” with Jonathan Bailor

#66 “The Calorie Myth” with Jonathan Bailor

Millions of enquiring minds want to know: Calories, do they count or not? What if everything you were taught about eating, exercise, weight loss, and health could be proven wrong? On this episode you’ll hear Jonathan Bailor make a pretty sane argument for no more calorie counting and how doing so may actually be bad for your health! Learn how to eat more to weigh less, why you’ll want to ignore that number on the treadmill, and how not to be a slave to willpower. There’s a lot going on in this show! Collaborating with top scientists for over 10 years, analyzing over 1,300 studies, and garnering endorsements by top doctors from Harvard Medical School, Johns Hopkins, Yale, and UCLA, Jonathan Bailor is a nutrition and exercise expert and  former personal trainer who specializes in using high-quality food and exercise to simplify wellness. He has registered over 25 patents and authored the revolutionary upcoming book “The Calorie Myth.”   Bailor serves as a Senior Program Manager at Microsoft, hosts a popular syndicated wellness radio show, blogs on The Huffington Post, and consults for organizations around the world. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Loka 201345min

#65 The Paleo Manifesto with John Durant

#65 The Paleo Manifesto with John Durant

Author of “The Paleo Manifesto” and professional caveman, John Durant, came on Bulletproof Radio to chat about primitive living in an urban jungle. In this fun and down to earth episode you’ll hear John and I talk about Paleo being a biohack and cricket-based protein! Whether you live in a cave now or just plan on retiring in one, there’s something in this show for everyone. John Durant is an author and health entrepreneur. He recently released his first book – The Paleo Manifesto: Ancient Wisdom for Lifelong Health – in which he advocates using evolutionary principles to combat the global epidemic of obesity, diabetes, and other chronic health conditions. He studied evolutionary psychology at Harvard before moving to New York City and becoming a “professional caveman”: running barefoot through Central Park, mimicking a hunter-gatherer diet, experimenting with intermittent fasting, and doing polar bear swims in the Atlantic. John has been featured in the New York Times, and interviewed on The Colbert Report and NPR Morning Edition. He keeps a freezer chest full of organ meats in the bedroom of his Manhattan apartment, and he is fully aware of how strange that is.     See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Loka 201351min

#64 Grass Fed Beef from the Mountains of Idaho, with Glenn Elzinga from Alderspring Ranch

#64 Grass Fed Beef from the Mountains of Idaho, with Glenn Elzinga from Alderspring Ranch

Alderspring Ranch produces some of the best tasting and highest quality grass fed beef in North America. Glenn Elzinga, expert organic rancher and owner of Alderspring Ranch, shares what goes into creating Bulletproof approved beef and why it’. For over 20 years Glenn and Caryl Elzinga have worked hard and stayed true to the land and the cattle that roam on it. It’s a family ranch with a ton of heart and in this episode you will hear Glenn and I really geek out about beef. You will learn about the roots of Alderspring, why it’s so important not to micro-manage roaming cattle, how eating grass fed beef makes you more Bulletproof, and a lot more! Alderspring Ranch is a real place, a family ranch. Glenn and Caryl Elzinga have grown grass fed and finished beef in Idaho’s Rocky Mountains for over 20 years. It is in the wild and pristine setting of Idaho’s high Pahsimeroi Valley that they found the ideal place to raise their certified organic Angus beef.  In addition, Glenn’s background in forest ecology and Caryl’s as a PhD in plant ecology specifically equipped them to manage their landscape-level ranch comprised of over 70 square miles of high elevation wildlands- one of the largest certified organic ranches in the U.S They are experts at producing top quality cuts of beef for the discerning public. They are the opposite of a corporate outfit or a front through which to funnel odd cattle. Their passion is to grow the best beef you’ve ever had, and do it in a way that benefits all parts of an agricultural system, including the consumer, the land, the community, the cattle, and family. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Loka 201358min

#63 Q&A: Heart Rate Variability, Food Sensitivities, and Charcoal

#63 Q&A: Heart Rate Variability, Food Sensitivities, and Charcoal

Being Bulletproof is about asking questions and getting answers. Take that suspicious spot on your calf, for example. Have you ever wondered what the heck it is? Have you ever questioned how marijuana can have an effect on heart rate variability? Each month, I record a special podcast to answer questions from the Bulletproof community. We pick the best questions that come from emails, Facebook, Twitter, the Bulletproof Forum, and the blog’s comment section. In this show you’ll gain access to a wealth of information that I hope will empower you on the way to living a more optimal life. Please enjoy! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Loka 201353min

#62 The New “Naked Calories” & Micronutrient, with Mira and Jayson Calton

#62 The New “Naked Calories” & Micronutrient, with Mira and Jayson Calton

Forget everything you thought you knew about micronutrients! Mira and Jayson Calton are back on the show to tell you the importance of micronutrients and discuss the new and improved “Naked Science.” You will hear about the dangers of micronutrient defficiency, the ABCs of optimal supplementation, and the importance of taking a properly formulated multi-vitamin. Did you know that in order to become micronutrient sufficient you would need to eat 27,575 calories a day of the standard American diet? Pretty crazy, right? The Calton’s have certainly done their research and this is definitely a podcast you don’t want to miss! Mira and Jayson Calton are among the world's leading experts on the topics of weight management, lifestyle medicine and micronutrient deficiency. In 2005 the Caltons’ lead a 100-country, 7 continent, 6-year global expedition to explore the dietary and lifestyle habits of people around the world– which also resulted in reversing Mira's advanced osteoporosis. The Caltons are columnists for First for Women magazine and Livestrong.com, and contribute regularly to media sources such as “Fox and Friends,” “Happening Now,” Headline News, NBC, ABC, AOL Travel, Prevention, Shape and more. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Loka 201355min

#61 Gluten Sensitivity, Celiacs & Bulletproofing Your Gut, with Dr. Tom O'Bryan

#61 Gluten Sensitivity, Celiacs & Bulletproofing Your Gut, with Dr. Tom O'Bryan

Have you heard? Gluten is harmful, but do you know why? Dr. Tom O’Bryan explains away dietary gluten, how it is detrimental to your health, and why it keeps you from being optimal – in a big way! He talks about his 30 years of experience in researching Celiac disease and gluten sensitivity and how you can drastically increase the quality of your life by getting rid of gluten in your diet. We also talk about the number one supplement he recommends to Bulletproof your gut, how gluten is like morphine, and if there are such a thing as “good” grains.  If you want to understand gluten in a way you never have before and learn how it affects your body, this episode   is for you! Dr. Tom O’Bryan is a nationally recognized speaker, workshop leader, healer, and researcher specializing in Celiac disease & gluten intolerance. He is a highly esteemed clinician in treating chronic disease and metabolic disorders from a Functional Medicine perspective. Dr. O’Bryan is the Sherlock Holmes for chronic disease & metabolic disorders, a triathalete, and a second-degree black belt in Aikido. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Syys 201352min

#60 Orgasmic Meditation & Hacking Your Sex Life, with Dr. Pooja Lakshmin

#60 Orgasmic Meditation & Hacking Your Sex Life, with Dr. Pooja Lakshmin

Discover orgasmic meditation (OMing) and the science behind it with Dr. Pooja Lakshmin, M.D., the CSO of OneTaste, and scientist at Rutgers University Newark Orgasm Laboratory. This episode discusses the relationship between orgasm and the nervous system, the importance of mindfulness, and how often men and women should orgasm for maximum performance in life. Be sure not to miss this stimulating episode! Formerly a psychiatrist at Stanford hospital, Pooja switched career paths after experimenting with OMing and researching the science behind it. She later moved across the country to New York City to study the neuroscience involved in OMing through fMRI imaging and clinical studies. Currently, Pooja continues to conduct OMing studies, while also venturing into further researching the male orgasm. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Syys 201346min

#59 Hacking Productivity, Forming Habits & 'Lift' iPhone App, With Tony Stubblebine

#59 Hacking Productivity, Forming Habits & 'Lift' iPhone App, With Tony Stubblebine

Learn how to unlock your Bulletproof potential from the CEO of the habit-building app, Lift. Tony Stubblebine shares his take on what habits are good to form, and how to develop and sustain those habits by creating a supportive lifestyle. Tony and I also dug deep into the performance and emotional aspects of being a CEO. If you are a productivity hack or a high performing businessperson, than you do not want to miss this episode! Tony Stubblebine co-founded Lift based on the idea that positive reinforcement and community support could be deployed universally to help people achieve their goals. Prior to Lift, he was the founder and CEO of CrowdVine Event Social Networks, which builds simple and powerful software to help people connect and meet. He was also a part of the Wesabe launch team, Director of Engineering at Odeo.com and O'Reilly Media, and authored Regular Expression Pocket Reference. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Syys 201354min

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