The Itch: Allergies, Asthma, Eczema & Immunology23 Loka 2025

#133 - What is Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)?

Living with constant congestion, facial pressure, or a loss of smell can make daily life exhausting. For many people, these symptoms are more than just allergies or a lingering cold. They may be signs of chronic rhinosinusitis with nasal polyps (CRSwNP).

Dr. Rohit Katial joins Kortney and Dr. G to unpack what CRSwNP really is, how it develops, and why type 2 inflammation plays such a key role. Together, they explain what’s happening inside the sinuses, what symptoms to look for, and when it’s time to see a specialist.

What we cover about CRSwNP:

What CRSwNP means: Chronic rhinosinusitis with nasal polyps is long-term inflammation of the nose and sinuses that lasts 12 weeks or more.
What nasal polyps are: Soft, fluid-filled sacs (often “grape” or “pea” sized) that block airflow and lead to congestion and smell loss.
Why it happens: Type 2 inflammation drives CRSwNP. Immune messengers like IL-4, IL-5, and IL-13 cause swelling and fluid buildup in the nasal lining.
Who it affects: CRSwNP often overlaps with asthma, allergies, or aspirin sensitivity (AERD or Samter’s Triad), making symptoms worse.
When to seek help: If congestion, pressure, or loss of smell lasts more than 12 weeks, see an allergist or an ENT specialist. Early care can prevent sinus damage and improve breathing and quality of life.

More episodes to support CRSwNP

Ep. 101: What is Type 2 Inflammation?
Ep. 102: Comorbidities of Type 2 Inflammation - Connecting the Dots Between Multiple Allergic Conditions
Ep. 109: Tezepelumab & Nasal Polyps - Inside the WAYPOINT Phase III Trial

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Made in partnership with The Allergy & Asthma Network.

Thanks to AstraZeneca & Amgen for sponsoring today’s episode.

This podcast is for informational purposes only and does not substitute professional medical advice. Always consult with your healthcare provider for any medical concerns.

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