Biohacking News Weekly Update : 1351

Biohacking News Weekly Update : 1351

Upgrade your biology in 10 minutes with this week’s rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.


This episode covers:


Vitamin D as the Surprising “Anti-Aging Pill”

A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn’t just for bones anymore — it’s a foundational longevity molecule.

Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm


The Supercentenarian Gene That Rejuvenates Old Hearts

Researchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It’s a glimpse into how gene therapy could soon democratize superhuman longevity.

Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html


FDA Closes the “GRAS” Loophole — Supplements Enter a New Era

The FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It’s the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.

Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter


Microbes That Trigger Autophagy — Your Gut as an Anti-Aging Switch

Scientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body’s built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.

Source: University of Basel — https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.html

Further reading: Neuroscience News — https://neurosciencenews.com/dietary-rna-cellular-aging-29757/


Your Medical Avatar Is Coming — The Digital Twin of You

Forbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it generative health — a revolution in predictive medicine where your data literally becomes your doctor.

Source: Forbes Innovation — https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/


This is essential listening for fans of biohacking, human performance, functional medicine, and longevity sciencewho want real, actionable tools from Dave Asprey — the father of biohacking and founder of Bulletproof Coffee.


With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your lifespan, and upgrade every system in your body and mind.


New episodes drop every Tuesday, Thursday, Friday, and Sunday. Dave asks the questions no one else will — and gives you the science-backed tools to become stronger, smarter, and more resilient.


Keywords: vitamin D longevity, telomeres, BPIFB4 gene, cardiac rejuvenation, supplement regulation, GRAS FDA, autophagy, microbiome, fermented foods, biohacking news, medical avatar, digital twin, predictive medicine, Daniel Kraft, quantum health, wearable AI, Dave Asprey, The Human Upgrade


Thank you to our sponsors!

TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.

HeartMath | Go to https://www.heartmath.com/dave to save 15% off.


Timestamps:

0:00 — Introduction

0:18 — Story 1: Vitamin D & Telomeres

1:02 — Story 2: Longevity Gene Therapy

1:49 — Story 3: FDA Supplement Reform

2:38 — Story 4: Gut Bacteria & Autophagy

3:46 — Story 5: Medical Avatars

4:53 — Weekly Protocol

5:42 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1411)

#67 For the Love of Fermentation with Jill Ciciarelli

#67 For the Love of Fermentation with Jill Ciciarelli

Fermenting phenomenon Jill Ciciarelli is on the show to talk about her healthy hobby turned full-time passion, food fermentation. It’s a discerning topic amongst Bulletproof Radio listeners and enquiring minds want to know: Is fermenting optimal or not? You’ll hear Jill and Dave share their personal experiences with eating fermented foods, how it improves Jill’s life, and why Dave’s still a bit skeptical. Jill Ciciarelli is the author of Fermented: A Four Season Approach to Paleo Probiotic Foods and founder of the health blog First Comes Health. She graduated from the Institute for Integrative Nutrition as a holistic health coach and is certified by the American Association for Drugless Practitioners. Ciciarelli lives in Pennsylvania with her husband and a cat named Quincy. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Loka 201342min

#66 “The Calorie Myth” with Jonathan Bailor

#66 “The Calorie Myth” with Jonathan Bailor

Millions of enquiring minds want to know: Calories, do they count or not? What if everything you were taught about eating, exercise, weight loss, and health could be proven wrong? On this episode you’ll hear Jonathan Bailor make a pretty sane argument for no more calorie counting and how doing so may actually be bad for your health! Learn how to eat more to weigh less, why you’ll want to ignore that number on the treadmill, and how not to be a slave to willpower. There’s a lot going on in this show! Collaborating with top scientists for over 10 years, analyzing over 1,300 studies, and garnering endorsements by top doctors from Harvard Medical School, Johns Hopkins, Yale, and UCLA, Jonathan Bailor is a nutrition and exercise expert and  former personal trainer who specializes in using high-quality food and exercise to simplify wellness. He has registered over 25 patents and authored the revolutionary upcoming book “The Calorie Myth.”   Bailor serves as a Senior Program Manager at Microsoft, hosts a popular syndicated wellness radio show, blogs on The Huffington Post, and consults for organizations around the world. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Loka 201345min

#65 The Paleo Manifesto with John Durant

#65 The Paleo Manifesto with John Durant

Author of “The Paleo Manifesto” and professional caveman, John Durant, came on Bulletproof Radio to chat about primitive living in an urban jungle. In this fun and down to earth episode you’ll hear John and I talk about Paleo being a biohack and cricket-based protein! Whether you live in a cave now or just plan on retiring in one, there’s something in this show for everyone. John Durant is an author and health entrepreneur. He recently released his first book – The Paleo Manifesto: Ancient Wisdom for Lifelong Health – in which he advocates using evolutionary principles to combat the global epidemic of obesity, diabetes, and other chronic health conditions. He studied evolutionary psychology at Harvard before moving to New York City and becoming a “professional caveman”: running barefoot through Central Park, mimicking a hunter-gatherer diet, experimenting with intermittent fasting, and doing polar bear swims in the Atlantic. John has been featured in the New York Times, and interviewed on The Colbert Report and NPR Morning Edition. He keeps a freezer chest full of organ meats in the bedroom of his Manhattan apartment, and he is fully aware of how strange that is.     See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

10 Loka 201351min

#64 Grass Fed Beef from the Mountains of Idaho, with Glenn Elzinga from Alderspring Ranch

#64 Grass Fed Beef from the Mountains of Idaho, with Glenn Elzinga from Alderspring Ranch

Alderspring Ranch produces some of the best tasting and highest quality grass fed beef in North America. Glenn Elzinga, expert organic rancher and owner of Alderspring Ranch, shares what goes into creating Bulletproof approved beef and why it’. For over 20 years Glenn and Caryl Elzinga have worked hard and stayed true to the land and the cattle that roam on it. It’s a family ranch with a ton of heart and in this episode you will hear Glenn and I really geek out about beef. You will learn about the roots of Alderspring, why it’s so important not to micro-manage roaming cattle, how eating grass fed beef makes you more Bulletproof, and a lot more! Alderspring Ranch is a real place, a family ranch. Glenn and Caryl Elzinga have grown grass fed and finished beef in Idaho’s Rocky Mountains for over 20 years. It is in the wild and pristine setting of Idaho’s high Pahsimeroi Valley that they found the ideal place to raise their certified organic Angus beef.  In addition, Glenn’s background in forest ecology and Caryl’s as a PhD in plant ecology specifically equipped them to manage their landscape-level ranch comprised of over 70 square miles of high elevation wildlands- one of the largest certified organic ranches in the U.S They are experts at producing top quality cuts of beef for the discerning public. They are the opposite of a corporate outfit or a front through which to funnel odd cattle. Their passion is to grow the best beef you’ve ever had, and do it in a way that benefits all parts of an agricultural system, including the consumer, the land, the community, the cattle, and family. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Loka 201358min

#63 Q&A: Heart Rate Variability, Food Sensitivities, and Charcoal

#63 Q&A: Heart Rate Variability, Food Sensitivities, and Charcoal

Being Bulletproof is about asking questions and getting answers. Take that suspicious spot on your calf, for example. Have you ever wondered what the heck it is? Have you ever questioned how marijuana can have an effect on heart rate variability? Each month, I record a special podcast to answer questions from the Bulletproof community. We pick the best questions that come from emails, Facebook, Twitter, the Bulletproof Forum, and the blog’s comment section. In this show you’ll gain access to a wealth of information that I hope will empower you on the way to living a more optimal life. Please enjoy! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Loka 201353min

#62 The New “Naked Calories” & Micronutrient, with Mira and Jayson Calton

#62 The New “Naked Calories” & Micronutrient, with Mira and Jayson Calton

Forget everything you thought you knew about micronutrients! Mira and Jayson Calton are back on the show to tell you the importance of micronutrients and discuss the new and improved “Naked Science.” You will hear about the dangers of micronutrient defficiency, the ABCs of optimal supplementation, and the importance of taking a properly formulated multi-vitamin. Did you know that in order to become micronutrient sufficient you would need to eat 27,575 calories a day of the standard American diet? Pretty crazy, right? The Calton’s have certainly done their research and this is definitely a podcast you don’t want to miss! Mira and Jayson Calton are among the world's leading experts on the topics of weight management, lifestyle medicine and micronutrient deficiency. In 2005 the Caltons’ lead a 100-country, 7 continent, 6-year global expedition to explore the dietary and lifestyle habits of people around the world– which also resulted in reversing Mira's advanced osteoporosis. The Caltons are columnists for First for Women magazine and Livestrong.com, and contribute regularly to media sources such as “Fox and Friends,” “Happening Now,” Headline News, NBC, ABC, AOL Travel, Prevention, Shape and more. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Loka 201355min

#61 Gluten Sensitivity, Celiacs & Bulletproofing Your Gut, with Dr. Tom O'Bryan

#61 Gluten Sensitivity, Celiacs & Bulletproofing Your Gut, with Dr. Tom O'Bryan

Have you heard? Gluten is harmful, but do you know why? Dr. Tom O’Bryan explains away dietary gluten, how it is detrimental to your health, and why it keeps you from being optimal – in a big way! He talks about his 30 years of experience in researching Celiac disease and gluten sensitivity and how you can drastically increase the quality of your life by getting rid of gluten in your diet. We also talk about the number one supplement he recommends to Bulletproof your gut, how gluten is like morphine, and if there are such a thing as “good” grains.  If you want to understand gluten in a way you never have before and learn how it affects your body, this episode   is for you! Dr. Tom O’Bryan is a nationally recognized speaker, workshop leader, healer, and researcher specializing in Celiac disease & gluten intolerance. He is a highly esteemed clinician in treating chronic disease and metabolic disorders from a Functional Medicine perspective. Dr. O’Bryan is the Sherlock Holmes for chronic disease & metabolic disorders, a triathalete, and a second-degree black belt in Aikido. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Syys 201352min

#60 Orgasmic Meditation & Hacking Your Sex Life, with Dr. Pooja Lakshmin

#60 Orgasmic Meditation & Hacking Your Sex Life, with Dr. Pooja Lakshmin

Discover orgasmic meditation (OMing) and the science behind it with Dr. Pooja Lakshmin, M.D., the CSO of OneTaste, and scientist at Rutgers University Newark Orgasm Laboratory. This episode discusses the relationship between orgasm and the nervous system, the importance of mindfulness, and how often men and women should orgasm for maximum performance in life. Be sure not to miss this stimulating episode! Formerly a psychiatrist at Stanford hospital, Pooja switched career paths after experimenting with OMing and researching the science behind it. She later moved across the country to New York City to study the neuroscience involved in OMing through fMRI imaging and clinical studies. Currently, Pooja continues to conduct OMing studies, while also venturing into further researching the male orgasm. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Syys 201346min

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