Season 2 EP 74 Interstitial Inflammatory Stasis: A New Lens on Chronic Pain Mechanisms

Season 2 EP 74 Interstitial Inflammatory Stasis: A New Lens on Chronic Pain Mechanisms

In this episode, we unpack the Interstitial Inflammatory Stasis (IIS) hypothesis introduced by Tuckey et al. (2021) in Frontiers in Pain Research. The authors propose that after injury or immune activation, inflammation can become “trapped” within the body’s microscopic fluid channels creating a self-perpetuating loop of congestion, fascial tension, and pain.

You’ll learn how this model integrates existing pain theories into one fascia-based framework. We’ll also explore how these ideas align with occupational therapy practice: restoring interstitial flow through movement, breath, manual therapy, and autonomic regulation.

Join the fascia-informed conversation: The Fascia-Informed Therapist ™ - Grounded in science. Practicing on the cutting edge.

References

Benias, P. C., Wells, R. G., Sackey-Aboagye, B., Klavan, H., Reidy, J., Buonocore, D., Miranda, M., Kornacki, S., Wayne, M., Carr-Locke, D. L., & Theise, N. D. (2018). Structure and Distribution of an Unrecognized Interstitium in Human Tissues. Scientific reports, 8(1), 4947. https://doi.org/10.1038/s41598-018-23062-6

Tuckey, B., Srbely, J., Rigney, G., Vythilingam, M., & Shah, J. (2021). Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism. Frontiers in pain research (Lausanne, Switzerland), 2, 691740. https://doi.org/10.3389/fpain.2021.691740

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Jaksot(91)

EP 91 Thermography and Fascia-Informed Care: What Can Skin Temperature Tell Us?

EP 91 Thermography and Fascia-Informed Care: What Can Skin Temperature Tell Us?

Thermography is increasingly marketed as a painless, noninvasive way to look at what may be happening in the body, but what can it actually tell us? In this episode, I explore infrared thermography th...

14 Syys 30min

EP 90 An Encore and an Opportunity for You

EP 90 An Encore and an Opportunity for You

In this episode, I'm replaying one of the most popular topics from EP 78. Most of us can improve on our understanding of stress and how it affects the body. The article by Huston (2022) presents a com...

17 Elo 40min

EP 89 Is Fascia a System? Not everyone thinks so. What do you think?

EP 89 Is Fascia a System? Not everyone thinks so. What do you think?

Each discipline operates from different rules and definitions. A system can be defined as "a set of things working together as parts of a mechanism or an interconnecting network; a complex whole". So,...

20 Heinä 14min

EP 88 Self-Treatment and Chronic Hand Pain (Altahif & Davis, 2026)

EP 88 Self-Treatment and Chronic Hand Pain (Altahif & Davis, 2026)

This episode explores lessons from Altahif and Davis (2026), a survey of hand therapy practitioners on self-management strategies for clients with chronic hand pain. The survey examined what clients w...

15 Kesä 38min

EP 87 OTs Don’t Cut: We Get Curious and Ask Questions

EP 87 OTs Don’t Cut: We Get Curious and Ask Questions

In this episode I share a real‑life phone call from a very young potential client who reached out about a tongue‑tie release and frenectomy, expecting a quick surgical solution. Instead of rushing to ...

1 Kesä 20min

EP 86 The Future of Fascia: A Scoping Review Yields Research Directions

EP 86 The Future of Fascia: A Scoping Review Yields Research Directions

In this episode of The Fascia Informed Therapist, we unpack a recent scoping review on the future of fascia research and translate its findings into practical clinical direction for occupational thera...

18 Touko 22min

EP 85 Lessons from a New Client: We see the body differently.

EP 85 Lessons from a New Client: We see the body differently.

In this episode I review the case of a new client who really made it hit home how we, as fascia-informed practitioners see the body differently. We engage with our clients differently and it gives the...

4 Touko 27min

EP 84 Different Approaches, One Client: Handling Clinical Contradictions

EP 84 Different Approaches, One Client: Handling Clinical Contradictions

What do you do when a client comes to you following advice that doesn’t align with your approach? In this episode, we explore how to navigate those moments with professionalism and clarity. Learn how ...

6 Huhti 26min

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