Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair
Huberman Lab30 Loka 2025

Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

In this Huberman Lab Essentials episode, my guest is Dr. David Sinclair, PhD, a professor of genetics at Harvard Medical School and a leading expert on the biology of aging. We discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body's natural longevity pathways. This discussion highlights how lifestyle choices profoundly influence the aging process and may even slow or reverse key aspects of biological aging. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AGZ by AG1: https://drinkagz.com/huberman David: https://davidprotein.com/huberman Eight Sleep: https://eightsleep.com/huberman Timestamps (0:00) David Sinclair (0:20) Longevity, Anti-Aging, Aging as a Disease (2:27) Causes of Aging; Epigenome & Genes (4:53) CD & Scratches Analogy, DNA, Silencing & Expressing Genes (6:44) Physical Appearance & Aging (7:36) Sponsor: David (8:54) Childhood Development & Aging, Horvath Clock, Accelerate Aging (11:30) Rates of Puberty & Aging, Growth Hormone (12:37) Body Size & Longevity; Epigenetics (13:07) Fasting, Calorie Restriction & Longevity, Sirtuins, Insulin & Glucose (16:31) Tool: Skip a Meal (17:07) Longer Fasts & Autophagy, “Deep Cleanse” (18:07) Sponsor: AGZ by AG1 (19:36) Fasting, Fluids, Electrolytes (20:16) Sirtuins, Glucose, mTOR & Fasting; Leucine, Tool: Pulsing Behaviors (24:24) Breaking a Fast, Tools: Do Your Best; Transitions (27:00) Sirtuins, NAD, NMN Supplementation (29:04) Sponsor: Eight Sleep (31:10) Iron & Senescent Cells; Personalize Medicine (32:40) Tool: Blood Markers, CRP (34:50) Tool: Aerobic & Resistance Exercise (35:55) Estrogen, Fasting & Fertility; Aging & Rejuvenation (38:20) Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

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How Your Brain Works & Changes

How Your Brain Works & Changes

Today’s episode provides an introduction to how the nervous system works to create sensations, perceptions, emotions, thoughts and behaviors, as well as how we can change our nervous system—a phenomenon known as neuroplasticity. The information sets the stage for all Huberman Lab podcast episodes that follow by covering neurons, synapses, brain chemicals and the rhythms that control our ability to focus, learn and sleep… and more. Thank you for your interest in science. We'll see you next week! Read the full show notes for this episode at hubermanlab.com. Use Ask Huberman Lab, our new AI-powered platform, for a summary, clips, and insights from this episode. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Timestamps 00:00:00 Introduction   00:02:25 Sponsors: AG1 & LMNT   00:07:57 What is the Nervous System   00:07:25 Deja Vu   00:08:09 How War, Guns & Soap Shaped Our Understanding of the Brain   00:10:47 Jennifer Aniston Neurons   00:11:58 Sensations   00:13:30 Magnetic Sensing & Mating   00:14:51 Perceptions & The Spotlight of Attention   00:16:33 Multi-Tasking Is Real   00:17:45 Bottom-Up vs. Top-Down Control of Behavior   00:18:38 Focusing the Mind   00:21:47 Antidepressants   00:25:01 Thoughts & Thought Control   00:25:56 Actions   00:30:40 How We Control Our Impulses   00:33:44 Neuroplasticity: The Holy Grail of Neuroscience   00:38:34 The Portal to Neuroplasticity   00:43:53 Accelerating Learning in Sleep   00:47:29 The Pillar of Plasticity   00:52:22 Leveraging Ultradian Cycles & Self Experimentation   00:57:17 Summary   00:58:03 Zero-Cost Support, Feedback, Reviews   Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

4 Tammi 20211h 1min

Welcome to the Huberman Lab Podcast

Welcome to the Huberman Lab Podcast

Welcome to the Huberman Lab podcast, a new podcast from Dr. Andrew Huberman. The podcast can also be found on YouTube. Learn more about your ad choices. Visit megaphone.fm/adchoices

21 Joulu 20204min

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