The Boring Secret Behind Celebrities Who Don’t Age : 1364

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Get Salty AF: https://drinklmnt.com/dave, get the LMNT sample pack for the cost of shipping, $5. (If you like it, try the new limited edition Mint Chocolate flavor for the holidays!)Unlock Your Brain with Customized Nootropics: https://nootopia.com/dave, use code DAVE10 to save 10% on your first order Track Blood Glucose: https://www.levelshealth.com/DAVE, sign up for the Beta groupSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSGo to https://www.quicksilverscientific.com and use code DAVE15 to save 15% all products.IN THIS EPISODE OF THE HUMAN UPGRADE™… … Christopher Shade, Ph.D., joins the show to take you through a new six-spoke “longevity wheel.” You’ll find out what you can do to live longer by managing toxins and hormones that influences aging.With expertise in environmental sciences, chemistry and biology, he founded the Colorado-based company Quicksilver Scientific. It’s a group of “chemists, biohackers and age rebels.”He specializes in the biological, environmental, and analytical chemistry of mercury in all its forms. He presents and teaches in the U.S. and nationally about mercury, environmental toxicities, neuroinflammation, immune dysregulation, and the human detoxification system.He's designed detoxification protocols, unique supplement delivery systems, and a patented mercury speciation test. As CEO, he continually drives development and innovation. Right now, the focus is longevity with a foundation in detoxification.Everyone has a meaningful amount of metals, plastics, molds or other toxins in their body and is pretty much operating with low-grade toxicity. And even though everyone has the same basic detoxification system, people react to and process toxins very differently. There’s a general universe of toxins: You have exogenous toxins from outside the body (metals, chemicals, mycotoxins or food-borne toxins). Then you have endotoxins, which are made on board usually by gut bacteria and lipopolysaccharide.That’s why cellular level detoxification matters so much. Bile flow, and knowing what blocks it and what opens it, plays a huge role in your body’s detoxification process.If you learn to think like a computer or especially a network engineer, there's a whole bunch of interrelated systems. If one of them is broken, it'll have an effect on the other. But when you look at detox pathways, you look at aging, it's a very similar mindset, way more so than you would think.Hormones, too, get in on the aging action. DHEA and pregnenolone are the mother hormones. All the other hormones are made out of those two things. “Hormones are necessary for all the detox reactions,” Chris says. “Having the right levels of all the hormones just powers everything up.”The six-spoke “Longevity Wheel” framework that Chris developed biohacks conventional aging assumptions. This wheel is a collection of biochemical pathways, mechanisms, and molecules that impact aging. Each spoke builds on another and all work together. Nrf2 and AMPKNADSirtuinsTelomeresSenolyticsNeuroendocrineListen on to find out more about how detox, hormones and the spokes of this new Longevity Wheel can impact how you age.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Joulu 20211h 17min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Nature’s Nootropic: https://trukava.com, use code DAVE15 for 15% offSupport Immune & Digestive Health: https://justthrivehealth.com, use code ASPREY to get 15% offEat Good Keto Bread: https://www.uprisingfood.com/DAVE, use code DAVE to get $10 off the starter bundle. That includes two superfood cubes and a four pack of freedom chips!SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSYou can order TRUAGE at https://trudiagnostic.com/dave-asprey and enter code ASPREY at checkout for $50 off.IN THIS EPISODE OF THE HUMAN UPGRADE™… …you’re going to discover how old you really are by taking a dive into the science of epigenetic methylation and biological aging. You’re going to find out about gene function, gene expression and what it has to do with how you age—and why it matters.Biochemist Ryan Smith co-founded TruDiagnostic, a company focused on methylation array-based diagnostics for life extension and preventive healthcare. TruDiagnostic, a CLIA certified lab and health data company, developed the TRUAGE anti-aging test. From a small blood test, TruDiagnostic can tell you your biological age—how old your body acts, based on how it’s functioning (as opposed to your chronological age, which is the number of years you’ve been on Earth). Biological age is one of the most impactful pieces of data you can have about yourself. Age is the number one predictor of death, and your biological age matters more than the number of times you’ve been around the sun. For example, you could be 42, and if you take great care of yourself, your biological age may be 30… Or, if you take poor care of yourself, your biological age may be 60. Either way, TruDiagnostic will tell you how old you really are. And their test goes further than that. After you discover your biological age, TruDiagnostic also gives you a list of strategies to reverse aging based on your unique genetics. In other words, you get personalized anti-aging biohacks—and you can test your age over time to see if you’re getting younger, so you know whether or not your anti-aging hacks are working.If you can turn back the clock on your biological age, you unlock the door to a longer, better life. It feels like the cusp of a big change in longevity research with science and data now more fully supporting this work. TruDiagnostic currently has over 30 approved clinical research studies underway investigating how epigenetic methylation changes impact how long you live and how well you age.In this episode, you’ll also learn:Why men age worse than women, and what you can do about itThe best ways to predict your biological age (hint: grip strength is one of them)How getting COVID changes the speed at which you ageWhy small amounts of stress are amazing for anti-aging (and the right ways to stress your body and brain so you age in reverse)See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Joulu 20211h 16min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Cardiovascular Health: https://arterosil.com/dave20/, get a 3-pack and save up to 30% plus free shippingHealth Upgrades with Custom Lab Testing and Your Data: https://get-base.com/DAVE, use code DAVE to get 20% off your first month of membershipTrack Blood Glucose: https://www.levelshealth.com/Dave, sign up for the Beta groupSPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERSGo to https://pendulumlife.com and use promo code DAVEVIP to get an exclusive discount. IN THIS EPISODE OF THE HUMAN UPGRADE™… …we get into the gut. If you’ve listened to my podcast before you probably know how much the gut is a culprit in disease. I’ve invited experts on the show to explain how without the right balance of good bacteria in your gut, you can have inflammation, poor immune response, GI distress and much more. Your gut lining is like a fence, explains Colleen Cutcliffe, Ph.D. It needs maintenance and attention, because that “fence” is what guards your gut from bad bacteria and toxins. Without it, you lose a strong defense system.That’s where Akkermansia comes in. This bacterial strain naturally found in the gastrointestinal tract helps regulate the mucus lining of the gut, while also fine-tuning immune responses. Only in recent years have people understood (and acted on) the gut microbiome’s role in wellness or disease. Dr. Cutcliffe shares the research behind Akkermansia and why this probiotic is changing the gut health game.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Marras 202153min

In this Episode of The Human Upgrade™...Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.Migraines diminish the quality of your deep and REM sleep.Microbiome bacteria can either help or harm people with Type 2 Diabetes.A safer contraception option for men means no testicle injections.Kids learn to manage big emotions by playing specially designed video games..New studies show 6.5 hours of sleep could be surprisingly good for you.EPISODE SPONSOR: Control Blood Glucose with Pendulum. Visit https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipment.LISTEN: "Follow" or "subscribe" to The Human Upgrade™ with Dave Asprey on your favorite podcast platform.REVIEW: Go to Apple Podcasts at daveasprey.com/apple and leave a (hopefully) 5-star rating and a creative review.FEEDBACK: Got a comment, idea or question for the podcast? Submit via this form!SOCIAL: Follow @thehumanupgradepodcast on Instagram and Facebook.JOIN: Learn directly from Dave Asprey alongside others in a membership group: https://ourupgradecollective.com.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Marras 202111min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Cut Your Cardio: https://carolbike.com, use code DAVE to get $100 off your orderNervous System Recovery: https://apolloneuro.com/dave10 to get 10% off an Apollo Neuro deviceUpgrade Your Magnesium: https://magbreakthrough.com/DAVE, use code DAVE20 to get 20% off. You’ll also get FREE bottles of BiOptimizers’ best-selling products with select purchases. Exclusive discount through November 30, 2021.IN THIS EPISODE OF THE HUMAN UPGRADE™…… you’ll find out how Alzheimer’s impacts women more often than men and how symptoms begin decades before you think they do. Six million people in America are experiencing Alzheimer’s. Two-thirds of them are women. My guests, Maria Shriver and Dr. Lisa Mosconi, are championing an increase in research, raising awareness and providing resources about this topic to find out why. The Alzheimer’s spotlight falls twice yearly because it’s just that important: November for National Alzheimer’s Disease Awareness Month and National Family Caregivers Month, and June for Alzheimer’s and Brain Awareness Month. A lot of the research happening to understand Alzheimer’s can benefit everyone. It can teach you how to lessen inflammation in your brain and get a handle on or prevent immune and metabolic brain disease. When you learn how to do that, you unlock cognitive performance and longevity. Maria and Dr. Mosconi offer some great insight and practical tips.Maria Shriver is a champion of Alzheimer’s awareness. For two decades she’s been reporting, writing and fundraising for it, specifically relating to how it impacts women. She founded the The Women’s Alzheimer’s Movement, a nonprofit that brings together doctors, researchers and brain experts to support Alzheimer’s research, clinical trials, and information sharing. It also provides public education, prevention tips and tools for brain health.“I think what happens is that there are small moments along the way that we all disregard,” Maria says. I think the challenge to be present in our own lives is a challenge, really, for all of us. The challenge to take note of our health is a challenge for all of us.”Dr. Mosconi is a neuroscientist and neuro-nutritionist focused on brain science, the microbiome and nutritional genomics, specifically the early detection of Alzheimer’s. Her research on women’s neurological health has changed the way science approaches the female brain. She speaks to the more than 10 years of research that shows Alzheimer’s starts with negative changes in the brain years – if not decades – before any clinical symptoms emerge.“It’s really important to take care of ourselves, and our brains are really one of our most important assets,” Dr. Mosconi says. “And the best way to engage in prevention is now. It's never too late to start, but the sooner we start doing it, the better.”Learn even more about how Alzheimer’s affects women and what to do about it:Maria Shriver On Why Alzheimer’s Is A Woman’s Problem – #497The Women’s Alzheimer’s MovementThe Shriver Report: A Woman’s Nation Takes on Alzheimer’sWomen, Menopause and Alzheimer’s: XX Brain Connections with Lisa Mosconi, Ph.D. – #675lisamosconi.com“The XX Brain: The Groundbreaking Science Empowering Women to Maximize Cognitive Health and Prevent Alzheimer’s Disease”“Brain Food: The Surprising Science of Eating for Cognitive Power”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Marras 202135min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Support Immune & Digestive Health: https://justthrivehealth.com, use code ASPREY to get 15% offTrack Your Health: https://info.insidetracker.com/dave, sign up to get your promo code for 25% OFF storewideMeasure Brain Function: Learn more and get a special discounted package at https://wavimed.com/, use code DAVESPECIAL OFFER FOR THE HUMAN UPGRADE™ LISTENERSGet Your Sleep Temperature Right: Go to https://www.eightsleep.com/dave to save $250 on the Pod Pro mattress padIN THIS EPISODE OF THE HUMAN UPGRADE™……you’re going to learn a bunch of brand new sleep hacks, taken from over a million nights of sleep data. Those hacks will come from my guest Matteo Franceschetti. Matteo defines high performance—having been a professional skier, high-level tennis player, competitive race car driver and practicing lawyer. He didn’t get much sleep doing all those things, so he co-founded Eight Sleep and set out to create and advanced sleep improvement device so he, and everyone else, could sleep better and perform better.We can all agree: “Sleep is a pillar, a fundamental pillar for your health,” Matteo says.Eight Sleep tracks biomarkers that measure your sleep quality. Then it uses machine learning to make automatic adjustments to your sleep environment. This helps you optimize your sleep, get the reset and recovery your body needs, and well, wake up feeling better than you have in years. Best of all, you don’t actually have to do anything. You just go to sleep, exactly like you did last night, and the technology does all the sleep hacking for you. TIME Magazine named Eight Sleep one of its “Best Inventions” of both 2018 and 2019, and Fast Company listed it as one of the most innovative companies of 2018. They’re a sleep hacking company making big inroads into understanding and regulating your body’s temperatures while sleeping. This affects your REM sleep the most.“While you are in REM your brain deactivates all the temperature controls in the body,” Matteo explains. “It doesn't let you fall into REM if it's too hot or too cold because you could potentially die. Changing the temperature based on your sleep stages and the different stages of the night is fundamental to maximize your deep and REM stages.”And Eight Sleep has a fix for that.“Based on your sleep stages and based on your biometrics, we adjust your body temperature during the night,” Matteo says. “It's not that we are inventing the wheel. Your body is already changing temperature during the night. It's part of your physiological process. We just enhanced that process to maximize your sleep performance.”And then I wanted to know, “How many hours of sleep per night do you think you can save people, by just changing temperature?” The point isn't necessarily to get less sleep, but it's to live more. Right? If you just got everything you needed and it was as good as what you have today, but you had enough time to do two hours of reading or learning every day or meditating or parenting or whatever else, it's not about working more necessarily. It's just about living more. It’s exciting to talk to Matteo because he brings a whole bunch of new biohacking ideas to the table, er bed. He and I get into a bunch of sleep topics during this conversation, including:How you can instantly increase your deep sleep by 40%, starting tonightHow you can reset your energy levels in the morning just by regulating your sleep temperature at nightHow you can compress sleep down to 5-6 hours a night, while actually getting more rest and recoveryWhy sleep consistency matters (and is still the hardest thing for people to do, well, consistently}Why machine learning is the future of personalized healthIf your sleep could use an upgrade, check out this episode for hacks you can implement right away and learn about what’s next in sleep technology. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Marras 20211h 5min

WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Supplement Bioavailability: https://www.quicksilverscientific.com, use code DAVE15 to save 15% on your first order Find Out Your Biological Age: https://glycanage.com, use code DAVE to get 20% off testing packagesNature’s Nootropic: https://trukava.com, use code DAVE15 for 15% offIN THIS EPISODE OF THE HUMAN UPGRADE™…… my guest fits right into the podcast transition to The Human Upgrade because he gets into the grittiness of what humans can do to level themselves up. No. 1 New York Times bestselling author Robert Greene shares science-backed knowledge about human nature.You know you want to be more powerful, more in control and excellent at what you do.Robert’s insights help you do just that. He gives you actionable tips that help you unlock limitations you may be putting on yourself so you can move your life upward and forward. (Similar to something I like to tell my team is great momentum: “up and to the right.”) World leaders, military generals, business executives, philosophers, and hip-hop moguls alike revere Robert’s books.After writing about mastery and power for more than two decades, he’s now become a TikTok sensation and the universal truth for a new generation. He’s one of my favorite authors who’s profoundly influenced my own life and been on the podcast twice before. Both episodes are must listens: The 48 Laws of Power – #380 and The Laws of Human Nature – #575. I asked him back to talk about his latest book: “The Daily Laws: 366 Meditations on Power, Seduction, Mastery, Strategy, and Human Nature.” “In “The 48 Laws of Power,” I talk about deception and con artists,” Robert says. “But in The Laws of Human Nature, it's almost about self-deception, how we're con artists with ourselves, how we create an image of ourselves as being morally right, being a good person, being intelligent, being rational, being empathetic. Whereas in fact, we're usually quite far below that ideal. … Because your default position is to always look externally and blame other people.”In “The Daily Laws,” he distills the best of his previous books and never-before-published material in to one amazing life guide for you. He lays out themes for each month of the year: Power, seduction, persuasion, strategy, human nature, toxic people, self-control, mastery, psychology, leadership, adversity and creativity. Within these themes he features a “daily law” for you to follow.“By not looking at ourselves in an honest way, and glossing over our own flaws and weaknesses, we become trapped in patterns of behavior that we cannot control,” Robert says in his new book. “As the years go by, and the misreadings, missteps, and unrealistic decisions pile up, we can become bitter confused, and damaged.”“The Daily Laws” is designed to reverse [these] toxic patterns and reconnect you to reality,” Robert says. “It takes aim at the various delusions we have all absorbed and seeks to attune your mind instead to the most entrenched traits of human nature and how our brains actually operate.”Listen on for the truth bombs.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Marras 20211h 24min

SPECIAL OFFER FOR THE HUMAN UPGRADE™ LISTENERSGo to https://timelinenutrition.com and use code UPGRADE10 to get 10% off the Urolithin A subscription plan of your choice.IN THIS EPISODE OF THE HUMAN UPGRADE™……I’m going down a rabbit hole of exciting scientific research and clinical studies supporting Urolithin A’s influence on your mitochondrial health. The short version? Urolithin A stimulates mitophagy and renews your mitochondria. Specific big things to know? It upgrades your cells, your strength levels and offers pretty powerful anti-aging benefits.And a fun thing to know? The origin story of Urolithin A has to do with beavers. (!)To find out the basis of Urolithin A and its relationship to pomegranates, check out my previous podcast featuring two experts on the subject: How to Get Fitter Cells, Stronger Muscles and a Longer Life – Timeline Nutrition with Dave Asprey – #772.This time, I’ve invited Dr. Anurag Singh to the show. His expertise lies in clinical development and translational research. That means he translates new discoveries in science into real-world stuff you can actually use. He’s worked for several consumer health and biotech companies; authored more than 30 articles for top science journals; and designed and led more than 40 clinical trials over the last 15 years. As Chief Medical Officer of Amazentis, the parent company of Timeline Nutrition and the maker of Mitopure, a Urolithin A product. “A lot of times in the nutrition world, people put extracts and blends of probiotics together and they just give it to healthy people and expect magic to happen,” says Dr Singh. “Here, we've actually done the deep dive of the signs and how this molecule hits mitophagy and mitochondrial health. Then, bringing it to human translation and commercialization. This is really the holy grail for real world evidence.”He’s spent seven years focused on Urolithin A research and clinical trials. His initial round of research with Urolithin A showed that it could increase aerobic endurance and increase grip strength. Urolithin A also is the first postbiotic shown to repair mitochondrial health via mitophagy. Mitophagy is the process of renewing your mitochondrial growth as you age. As healthy mitochondria get older they accumulate free radicals and reactive oxygen species. They lose shape and stop communicating with one another, too. These faulty mitochondria have need to be replaced. Urolithin A revs up the mitochondrial recycling.Dr. Singh explains how you can get the benefits of Urolithin A and how to take it to achieve results.“Our gut microbiome is very complex ecosystem with hundreds of millions of different species interacting with each other,” explains Dr. Singh. “They need to be interacting in perfect harmony to release these postbiotics, which is the way I look at it is the perfect gut health relationship within the microbiome. So it's not one bacteria. It's not one strain that you can isolate and give. It's really got to be multi-species. I think you can probably conceptually find that strain or probiotic that could do it, but the process will be so inefficient that the best way is to short circuit it and provide the postbiotic, which is Urolithin A, directly in a pill or in a food product.” Another direction for Urolithin A is sports performance. Amazentis teamed up with renowned researcher Dr. Louise Burke in Australia to look into how Urolithin A affects mitochondrial health in athletes. Those results will be available in 2022.The future of Urolithin research keeps going in exciting new directions, including brain health. “So, there's a lot of research going on around this molecule,” Dr. Singh says. “[The] Buck Institute of Aging in California just got a multimillion grant from the National Institute of Health to study the effects of Urolithin A on the cognitive aging and how it can reverse some of the neuronal circuitry to look youthful. So we are actively looking at it and keeping our eyes and ears open for exactly feedback like this because brain cells also after muscle cells have the highest number of mitochondria that decline with aging.”See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Marras 20211h 3min