10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



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• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)

• Dave Asprey’s BEYOND Conference: https://beyondconference.com

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated

• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jaksot(1430)

Graham Hancock: Visionary Plants, DNA and Human History - #278

Graham Hancock: Visionary Plants, DNA and Human History - #278

Graham Hancock is a researcher, best-selling author and unconventional thinker who raises controversial questions about humanity's past. Most recently, he wrote 2015's The Magicians of the Gods, a book exploring the possibilities of lost ancient civilizations. His works have sold more than five million copies worldwide and have been translated into 27 languages. His public lectures, radio and TV appearances have put his ideas before audiences of tens of millions. On this episode of Bulletproof Radio, Dave picks Graham's brain on topics including government censorship, historical narratives, Ayahuasca use, DNA, raising smart kids and more! Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Tammi 20161h 19min

Alexander Wunsch: Light Medicine, Photobiology and Vitamin D  - #277

Alexander Wunsch: Light Medicine, Photobiology and Vitamin D - #277

Alexander Wunsch is physician, researcher and teacher in light medicine and photobiology with particular interest in light effects and beneficial / adverse health impacts of solar radiation and artificial light sources on endocrine and cellular levels in humans. In his medical office in Heidelberg he develops and applies therapeutic light spectra in combination with other biophysically based treatments. He also presents at international conferences and acts as a consultant for federal authorities and the lighting industry. On this episode of Bulletproof Radio, Dave gets Alexander's expert opinion on light medicine, LED lights, computer color temperatures, how to put color in our environment and more! Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Tammi 20161h 4min

January Q&A: Light Therapy, Lipoic Supplements, Dental Health & More! - #276

January Q&A: Light Therapy, Lipoic Supplements, Dental Health & More! - #276

In this episode of Bulletproof Radio, we've selected the best questions that Bulletproof fans submitted voicemail, Facebook and the Bulletproof® Forums, for another great Q&A. Hear Dave answer questions with recurring guest Dr. Mark Atkinson about light therapy, the Bulletproof Conference, mercury amalgam teeth fillings, alpha lipoic acid, handling mouth ulcers and alternatives to coconut oil. This episode covers a variety of topics based on your questions. Thank you and enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Tammi 20161h 3min

Stella Grizont: The Science of Happiness - #275

Stella Grizont: The Science of Happiness - #275

Stella Grizont is the Founder and CEO of WOOPAAH, dedicated to helping people and their companies flourish. WOOPAAH is loved by Google, Johnson & Johnson, Columbia University and many more awesome organizations for their programs in work place culture design, engagement and well-being. Her online course, The Science of Happiness, Hacks & Skills To Flourish, is a best seller on the leading online learning platform, udemy.com. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Tammi 20161h

Wesley Chapman: Creating Clarity, Power & Hope - #274

Wesley Chapman: Creating Clarity, Power & Hope - #274

Wesley Chapman's personal story is one of tragedy and success. Today, he is the co-founder A HUMAN PROJECT, a 501c3 with a mission to create a community of empowered youth. He is also the founder of SUPER HUMAN LIFE, a program designed to ensure ultimate understanding of one's true potential. Has appeared on FOX, ABC, A&E and many other national broadcast platforms and is the co-host of THE HUMAN PODCAST. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Tammi 201655min

Dr. Kellyann Petrucci: Bone Broth to Regain Energy, Reverse Aging & Lose Weight - #273

Dr. Kellyann Petrucci: Bone Broth to Regain Energy, Reverse Aging & Lose Weight - #273

Kellyann Petrucci, M.S., N.D., is the author of Dr. Kellyann's Bone Broth Diet. A weight-loss and natural anti-aging transformation expert, Dr. Petrucci has a private practice and is a concierge doctor for celebrities in New York City and Los Angeles. Dr. Petrucci is a regular guest on television shows including The Doctors, Dr. Oz, and national news programs. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

8 Tammi 20161h 4min

Dr. David Ludwig: Food Addiction & Why Will Power is Not Enough - #272

Dr. David Ludwig: Food Addiction & Why Will Power is Not Enough - #272

David S. Ludwig, MD, PhD is a practicing pediatrician and researcher at Boston Children's Hospital. He holds the rank of Professor of Pediatrics at Harvard Medical School and Professor of Nutrition at Harvard School of Public Health. Dr. Ludwig is Founding Director of the Optimal Weight for Life (OWL) program at Children's Hospital, one of the country's oldest and largest multidisciplinary clinics for the care of overweight children. He also directs the New Balance Foundation Obesity Prevention Center. His research focuses on the effects of diet on hormones, metabolism, and body weight. Dr. Ludwig is Principal Investigator on numerous grants from the National Institutes of Health, has published over 150 scientific articles, and presently serves as Contributing Writer for JAMA. Enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

5 Tammi 20161h 9min

Bulletproof Radio 2015 in Review!  #271

Bulletproof Radio 2015 in Review! #271

2015 was huge! This year Bulletproof hit some major milestones: the podcast surpassed 20 million downloads, our conference attendance almost doubled from 2014, we launched our documentary, Moldy, opened our Bulletproof coffee shop in Santa Monica and launched The Bulletproof Cookbook - featuring recipes to help you kick more ass at life! All of this is possible because you are interested in taking control of your health. Thank you for inspiring us to keep learning and growing. There are so many exciting things to look forward to in 2016, cutting-edge podcast guests, top of the line upgrades, and the best in biohacking. This Bulletproof Radio episode is a recap three favorite interviews from 2015, and features short clips of the best biohacks, bits of motivation, and life-upgrading information from Brendon Burchard, Dr. Joseph Mercola & Gary Taubes. Thanks for listening and please enjoy the show! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Joulu 201556min

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