10-Minute Biohacking News Update : 1367

10-Minute Biohacking News Update : 1367

This episode covers:


Nano CBD Pain Relief Without Cognitive Side Effects


A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support.

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm



Moderate Calorie Restriction Slows Biological Aging


A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting.

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults


FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s


The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair.

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/


Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules


Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.”

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged)


Klotho: The Longevity Protein Nears Clinical Reality


The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols.

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged)


All source links provided for easy reference to the original reporting and research above.


This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living.


New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates


Thank you to our sponsors!



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• Upgrade Collective: https://www.ourupgradecollective.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen: https://40yearsofzen.com

Timestamps:

0:00 — Intro

0:19 — Story 1: Nano CBD for Pain Relief

1:53 — Story 2: Caloric Restriction and Aging

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s

4:50 — Story 4: Microbiome Reprogramming

6:05 — Substack Announcement

7:04 — Story 5: Klotho Longevity Protein

8:39 — Weekly Homework

9:31 — Outro

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Mini-Episode: Cool Facts Friday #26

Mini-Episode: Cool Facts Friday #26

In this Episode of The Human Upgrade™...​Cool Facts are quick hits of new human and world science curated into short bursts of information just for you. This fun compilation publishes one Friday a month.• Gut bacteria convert vitamin A to retinoic acid• Low-carb diets contribute to depression • Lifestyle affects cognitive health more than age • More bad news about America’s obesity epidemic EPISODE SPONSOR: Sleep Better on Natural Memory Foam: https://myessentia.com, use code DAVEVIP to get an exclusive discount. Learn more: Mattress Smarts 101 for High-Performance Sleep – Jack Dell’Accio – #875.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Elo 202210min

Nillion Gives Crypto & Data Security a Human Upgrade – Conrad Whelan : 971

Nillion Gives Crypto & Data Security a Human Upgrade – Conrad Whelan : 971

Dave Asprey partners with Nillion as an advisor and investor.IN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll learn about the frontier of web3 and privacy and what happens to your private data (both on blockchains and in general). You’ll also find out how and why the future moves away from transactions (blockchain) and into computations (multi-party computation). Think about where you store your identity and your deepest digital secrets. The current solutions aren’t great — in web2, the Big Tech 'old guard' has been quietly storing and monetizing your data for over a decade, and in web3, blockchains aren't designed to handle private data. A new algorithm, Nillion, inspired Conrad Whelan (the Founding Engineer of Uber) to come out of early retirement and do something about this. This conversation looks at the data you unassumingly give away freely, and how it’s captured, held and used/computed on without your consent by large companies and other parties. Conrad believes in a future where your sensitive data and digital secrets can be fully controlled by you (and you alone) using web3 technology. This means you’d be the final gatekeeper of your data with the power to authenticate, authorize and use it as you see fit.Conrad’s building that future as Nillion’s Founding Chief Technology Officer. His background includes electrical and computer engineering. He worked in the fields of computational electromagnetics before joining Uber as Founding Engineer. He’s developed, tested, deployed and architected software projects at all levels of the software stack as both an engineer and an engineering manager.In 2016, he retired to focus his efforts on philanthropy and personal passion projects while keeping an eye on the tech world. The promise and potential global impact of Nillion enticed him out of retirement and into the company’s CTO role. What Conrad is building at Nillion aims to:render both computational encryption and centralized storage of private data obsolete;fundamentally change the way private data is stored and processed;offer alternative non-blockchain ways of using decentralized nodes;serve as a ‘Meta Layer’ that provides new and additional functionality to existing blockchains; andenable a host of new real-world applications on its native public network (the Nillion Network).Whatever your level of tech understanding, this discussion offers critical insights about the next big move in decentralized computing and data privacy.Find more info in the show notes on this episode's webpage: https://daveasprey.com/conrad-whelan-971/WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Capture Life Force Energy: https://leelaq.com, use discount code DAVE10 to get 10% off sitewideBusiness Growth With SEO: https://www.stephanspencer.com, get a FREE consultationA Cleaner Nicotine Alternative: https://lucy.co, use code DAVE20 for 20% off your first order See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Elo 202247min

How Regenerative Systems Save the Soil, Animals & You – Robby Sansom : 970

How Regenerative Systems Save the Soil, Animals & You – Robby Sansom : 970

IN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll learn why regenerative methods for taking care of soil and raising animals provide a solution that creates food sovereignty, improves human health, and helps reverse climate change. Previous episodes of this podcast featured regenerative farming and soil conservation topics. Dave Asprey keeps the conversation going because when you know what’s happening and what companies are doing about this problem, you can be informed and take action to support regeneration efforts in your own way.Robby Sansom, co-founder and CEO of Force of Nature, joins the show to talk about the new developments igniting real change. His roots run deep in the natural food community, caring for soil and caring for animals. He spent much of the last decade studying regenerative agriculture at ranches all over the world. Through this education, he helped found the Austin, Texas-based regeneratively sourced meat company, Force of Nature. The company’s building brand new global supply chains of grass-fed and regeneratively managed livestock. Force of Nature works in partnership with land stewards, ranchers and farmers committed to creating a positive return on the planet. There’s an undeniable sense of urgency about the state of soil and its ability to provide enough food for a growing population. Over more than a hundred years of conventional farming and ranching depleted land and disrupted natural ecosystems. These harms (have and continue to) adversely affect animal and human health. Force of Nature focuses on repair and regeneration—in their own operations and by educating farmers and ranchers from homesteaders to big corporations.In spring 2022, Force of Nature hosted a What Good Shall I Do? event about learning and leading with regenerative intent. This educational forum hosted several dozen speakers from soil scientists to leaders in the regenerative movement to individual farmers and ranchers. By providing information, resources and tools, conventional farmers and ranchers can make the switch to regenerative methods. And farmers and ranchers who already use regenerative methods can improve and have even more impact.You can get involved, too! In this episode, Robby talks about the true cost of meat and gives tips on what to look for in your own local grocery and how you can support regenerative agriculture and ranching in a way that aligns with your own values. Every small step toward change contributes to a larger movement.SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: Visit https://forceofnature.com and use code dave10 to get 10% off your first order.DON’T MISS THIS! Force of Nature will be providing meat at select 8th Annual Biohacking Conference events coming up in September. Get your ticket.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Elo 202258min

How Prebiotic Fiber Makes a Gut-Friendly Bread – Uprising Food : 969

How Prebiotic Fiber Makes a Gut-Friendly Bread – Uprising Food : 969

Uprising Food sponsored this podcast. Dave Asprey partners with Uprising Food as an advisor and investor.IN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll learn about bread that’s better for your body—and the important role of prebiotics and fiber in that equation. You’ll also find out about the science that supports new ways of creating bread products—what works and why it works. And you’ll get a look further into the food system and how to adopt solutions with real benefits for your energy and lifestyle.A 5+ year biohacker, intermittent faster, and cyclical keto devotee joins the show to talk about innovations in bread as you know it. William Schumacher, co-founder and CEO of Uprising Food—aka—”The Loafer and Chief”— traded in corporate life as a former Procter and Gamble marketer to sift through the disinformation to de-villainize bread and create products that taste good and work in synergy with your body.With all the gluten-free and alternative breads out there competing for attention, what made Uprising stand out to Dave Asprey? Simple. Uprising took action to:tackle the foundational things that give people disproportionate bang for their buck when they eat the products day in day out. figure out what’s NOT in the product. Most products are loaded with things that are doing damage and there’s a big-time cost. eliminate gluten and other inflammatory ingredients.choose ingredients that would produce a tasty, functional product and work in the gut to enable inside out transformation.partner with artisanal bakers willing to experiment with baking methods and ingredients. The star ingredient? Psyllium. In this conversation, you’ll get all the details on prebiotic fiber and the benefits of activated psyllium, a bio-active polysaccharide.Research done at Wright State University Microbiome Labcompared Uprising Food bread with traditional bread. Early results show that Uprising’s prebiotic bread makes nice with gut microbiota.Curious about bread again? Check out the Uprising Food “Toast Cleanse,” affectionately known as “72 hours to digestive deliverance.” This 3-day protocol includes super toast combinations and levels of bread eating designed to overhaul your microbiome. SPECIAL OFFER FOR THE HUMAN UPGRADE LISTENERS: www.uprisingfood.com/DAVE, use code DAVE to get $10 off the starter bundleExcited about bread that’s better for you? Learn how you can invest in Uprising Food here. WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Structure Water Molecules; Achieve Body/Brain Coherence: https://analemma-water.com, use code DAVE10 for 10% offExperience the High Life with Infrared Therapy: https://higherdose.com, use code HUMAN10 for 10% off Mattress Temperature Tech: https://www.eightsleep.com/dave, use code dave to save $250 on the Pod ProSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Elo 202248min

Ancient Healing Arts for Your Modern Life – Shaman Jorge Hachumak : 968

Ancient Healing Arts for Your Modern Life – Shaman Jorge Hachumak : 968

IN THIS EPISODE OF THE HUMAN UPGRADE™... … you’ll learn about shamanism, “spiritual minimalism” and how traditional healing arts connect so profoundly to the natural world. This conversation also explores distinct themes of consciousness, the soul, and deep respect for plant medicine and Ayahuasca ceremony. The guest, Shaman Jorge Hachumak, is a Peruvian of Spanish descent who’s made a winding journey into shamanism as a healer. After receiving a European education, he became a practitioner of Chinese Qigong in old Lima’s (Peru) China Town. After a successful career in tai chi competition, he worked with elderly patients in hospitals in Northern Peru. During this time, he was taken under the wing of native shamans, witches and herbalists who spent years teaching him the ancient healings. He learned ancient Peruvian medicine arts (not from the Incas, but from the North Coast and the Northern jungle of the Amazon).He now moves seamlessly between perspectives, having one foot firmly in the rational, scientific world and another in the spirit world.“The ancient healing arts are deep and expansive—you never stop learning, and what you learn in a lifetime will always be a small fraction of what is available to learn,” he says in his new book, “Journeying Through the Invisible: The Craft of Healing With, and Beyond, Sacred Plants, as Told by a Peruvian Medicine Man.” “I want to offer a larger picture of the Medicine Craft and to create appreciation for other important aspects that are endangered or still not well-known.”This larger picture includes influences from science, history, religion and the natural environment.Shaman Hachumak looks at consciousness as two states that lead to both deep understanding of the healing arts and deep self-reflection:Suffering Consciousness keeps us stuck in our negative waysSoul Consciousness is awakened during a ceremony or spiritual moment. Your entire being awakens, and you are shown the way to live according to the dictates of your conscience and the teachings of the spirits.He also uses his knowledge and experience to broaden people’s understanding of Ayahuasca as a powerful plant medicine. He works to protect Ayahuasca and the traditional ceremony from misuse and exploitation. WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Probiotic Eases Stress: https://www.omnibioticlife.com/DAVE, use code DAVE20 to get 20% off Vascular System Protection:https://arterosil.com/DAVE/, save up to 45% a 3-pack to protect your blood vessels from vulnerable plaqueHydrate with Electrolytes: https://DrinkLMNT.com/DAVE, get a FREE LMNT Sample Pack with 8 single-serving packets for the cost of shipping ($5 for U.S. customers) See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Elo 20221h 11min

What Biohacking Borrows from Shamanism – Manvir Singh, Ph.D. : 967

What Biohacking Borrows from Shamanism – Manvir Singh, Ph.D. : 967

IN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll find out about the relevance of shamanism in a modern world and why high performers are turning toward shamanic practices to get ahead.The show’s guest, Manvir Singh, Ph.D., is an anthropologist at the Institute for Advanced Study in Toulouse, France. He studies universal or near-universal cultural practices, including music, shamanism, and witchcraft. For the past seven years, he’s conducted ethnographic fieldwork in Indonesia. He recently wrote an article in WIRED magazine titled, “The Shamanification of the Tech CEO,” noting some curious parallels.“Silicon Valley austerity continues to grow more extreme. By 2020 intermittent fasting was no longer enough, and dopamine fasting—an abstention not just from food but from any form of stimulation, including music, eye contact, and playing Magic: The Gathering—had taken off. These self-denial fads are often touted as biohacking innovations. Yet as an anthropologist who has studied austerity in some of the most remote regions of the world, I see them as part of a larger pattern: the self-shamanification of tech CEOs.”“Analyzing an old dataset of 43 nonindustrial societies, I found that shamans in 81 percent of the societies observed prohibitions on food, sex, or social contact. Given that these data were collated from reports by travelers and anthropologists, they are probably an underestimate. Silicon Valley deprivation, it turns out, is less a strange, new development and more the most recent manifestation of a ubiquitous shamanic practice.”This conversation gets into:shamanism in generalthe cultural significance of shamanshow shamanic practices have made their way into modern culturewhy humans think they need shamans—or similar “magic” or “other” beings More about Manvir Singh, Ph.D.: Manvir earned a Ph.D. in Human Evolutionary Biology at Harvard University and a Sc.B. with Honors in Human Biology: Evolution, Environment, & Ecosystems at Brown University. He’s received multiple awards, honors, grants and fellowships—from Fulbright Scholarship to visiting scholar and research fellow. He’s written more than a dozen peer-reviewed journal articles and more than a dozen articles for general audiences. He gives talks domestically and internationally on the topic of shamans.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Control Blood Glucose: https://pendulumlife.com, sign up for membership to get monthly supply delivery, use code DAVE20 to save $20 on your first shipmentIncrease BDNF and Support Neurogenesis: Go to https://nootopia.com/davegenius, use code DAVE10 to get an extra 10% offIsometrics for Cardiovascular Health: https://www.zona.com, use code DAVE2022 to get $150 off the Zona PlusSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

16 Elo 20221h 6min

How To Be Your Future Self Right Now – Benjamin Hardy, Ph.D. : 966

How To Be Your Future Self Right Now – Benjamin Hardy, Ph.D. : 966

IN THIS EPISODE OF THE HUMAN UPGRADE™...… you’ll find out how your imagined future directs your behavior right now, rather than your past. You’ll learn how to manage threats to your future self, recognize truths about your future self, and how to take steps to be your future self. You’ll also gain strategies you can start using today for creating and becoming exactly who you want to be in the present moment.Benjamin Hardy, Ph.D., is an organizational psychologist and author of multiple books on how to improve your mindset. He joins the show to explain how you can borrow from your future and actually be that person right now. In his newest book, “Be Your Future Self Now: The Science of Intentional Transformation,” he says, “Research now shows that a person’s past does not drive or dictate their actions and behaviors. Rather, we are pulled forward by our future.” There’s no looking back, only moving ahead. Most people, out of fear, limit their view of the future to a narrow range. Take a dangerous leap to think more broadly. Take cues from your brain.“With neuroscience, the brain is essentially considered a prediction machine,” Ben says. “So, what the brain is always doing is predicting what's going to happen, and learning is essentially just updating its sense of predictions. The brain is always anticipating the future.”Since you’re already thinking about the future, put those thoughts to use in the here and now with 21 actions (7 threats to, 7 truths about, and 7 steps for being your future self) designed to transform yourself. For example:Offset a THREAT: Urgent battles and small goals keep you stuck. To exit the rat race of day-to-day mindset requires a shift in your focus. Face a TRUTH: Failing as your future self is better than succeeding as your current self. The more willing you are to invest in momentary loss and pain directed at a goal, the faster you’ll adapt to the level of your future self. Take a STEP: Schedule your future self. Put the important before the urgent. Once you commit to your Future Self, you’ll be required to be courageous. Choosing freedom over security is an act of courage.WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Calm Your Nervous System: Give the sensation of a hug, deep relaxation and better sleep: https://balooliving.com/dave, use code DAVE for a special discountTasty Keto Bread & Chips: https://www.uprisingfood.com/DAVE, use code DAVE to get $10 off the starter bundleSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

12 Elo 20221h 7min

Control Your Mindset with 4 Questions – Legacy Upgrade ft. Byron Katie : 965

Control Your Mindset with 4 Questions – Legacy Upgrade ft. Byron Katie : 965

IN THIS EPISODE OF THE HUMAN UPGRADE™...…a legacy upgrade conversation with Byron Katie will have you digging deep into the work of fine-tuning your mindset. Her keystone practice, The Work, allows you to access the wisdom you already hold inside you. She explains it as a process to “clear the mind.”You’ll ask yourself four questions and apply them to a specific problem you’re facing. Going through these steps gives you perspective and a new way of thinking about what’s causing you distress. Questioning diminishes the power your thoughts have over you. And THAT leads to true freedom.Her work contains elements of therapist, a counselor or a religious leader, though she’s technically not any one of these. She’s been described as a spiritual mentor. As the bestselling author of “Loving What Is: Four Questions That Can Change Your Life," followed by "A Mind at Home with Itself: How Asking Four Questions Can Free Your Mind, Open Your Heart, and Turn Your World Around," her inspirational guidance offers people a different way to think their thoughts so they can change their mindsets and, ultimately, their lives.Her own story of early life success that spiraled into depression, rage, addiction, and self-loathing, sets the foundation for The Work. “The thoughts like, “I’m not good enough. There's something wrong with me," which was true,” Byron explains. “It was my thinking. My thoughts were aimed out at other people. It was their fault. Then when I would say or do something, I would experience the guilt, so I had this vicious circle going of judgment, guilt, judgment, guilt. It was debilitating.”She had to save herself. Several weeks into treatment, she woke up one morning to a state of constant joy that has never left her and four questions clearly in her mind that would lead her out of her own darkness. She’s never been able to truly explain this epiphany, nor has she evangelized it. She realized that when she believed her stressful thoughts, she suffered, but that when she questioned them, she didn't suffer, and that this is true for every human being. She simply shares The Work with people who want to make profound life changes—and has continued this path for nearly 40 years.“I have a lot of people across the globe that are saying their lives are shifting so dramatically they're unrecognizable, but I don't call it The Work for nothing,” she says. “It does take stillness. It takes silence, and it takes being courageous enough to look at the thoughts in your head without trying to change them and accept them the way they are.”WE APPRECIATE OUR PARTNERS. CHECK THEM OUT!Kickstart Autophagy: https://timelinenutrition.com/DAVE, use the code ASPREY10 to get 10% off any planMattress Temperature Tech: https://www.eightsleep.com/dave, use code dave to save $250 on the Pod ProSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

9 Elo 202253min

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