BBC Inside Science

Claims by a Chinese scientist that he has gene-edited human embryos, transplanted them producing genetically edited twins, who will pass on these changes to their offspring, has the scientific community outraged. The work, which was carried out in secret, has not been officially published or peer reviewed, but if the claims are to be taken seriously, this work severely flaunts international ethical guidelines at many levels. BBC Health and Science Correspondent James Gallagher explains the story so far.Little is known about the placenta and how it works, despite it being absolutely essential for supporting the baby as it grows inside the mother. When it doesn’t function properly, it can result in serious problems, from pre-eclampsia to miscarriage, with immediate and lifelong consequences for both mother and child. Our knowledge of this important organ is very limited because of a lack of good experimental models. Animals are too dissimilar to humans to provide a good model of placental development and implantation, and stem cell studies have largely proved unsuccessful. But one group of University Cambridge researchers have now created ‘mini-proto placentas’ – a cellular model, growing long-term, in 3D of the early stages of the placenta – that could provide a ‘window’ into early pregnancy and help transform our understanding of reproductive disorders. The Woodland Trust want you to tell them when you notice a tree, you regularly see, loses all of its leaves. Its part of their long term phonological study, Nature's Calendar . They hope to keep track of the effect of climate change on the timings of annual tree events.

29 Marras 201828min

The Government's strategy to eradicate TB in cattle is a contentious topic. The disease is extremely complicated and lots of people have different ideas on how to manage it. Professor of Zoonotic and Emerging Disease at the University of Nottingham, Malcolm Bennett, helps Adam Rutherford understand just how complex the TB bacterium is, how difficult it is to test for infection and why the vaccine BCG does and doesn't work and answers listener's question of why don't we vaccinate cows? Citizen scientists and their smartphones are being recruited to test the supermassive particle theory of dark matter and dark energy. The CREDO (Cosmic-Ray Extremely Distributed Observatory) project utilises smartphone cameras to take 'dark photos' and hopefully capture a particle collision that could be from the cascaded decay of these early universe massive particles or WIMPS.Metrologists from across the world have just voted to update the metric system. With the redefinition of the kilogram, alongside the units for temperature, electrical current and amount of substance. For the first time, we now have a measurement system defined by fundamental constants of the universe and not physical artefacts made by humans. Reporter Henry Bennie travelled with the UK's kilogram to Paris for the vote. NASA's Mars InSight mission lander is expected to touch down on the red planet on Monday. BBC Science Correspondent, Jonathan Amos, explains to Adam just how this stationary science lab will explore Martian geology looking for signs that life could have existed at one time on our neighbour.Producer: Fiona Roberts

22 Marras 201837min

The Bovine TB Strategy Review has just been released. It contains a review of the science and offers advice and guidance to Government ministers on how to eradicate this costly and hard to manage disease in cattle. Controversially it does not include the results from the on going badger culling trials in the West of England and it states that the majority of disease transmission is from cow to cow. But it addresses the efficacy of skin TB tests and repeatedly states that the long-term aim is to end culling badgers and moving to vaccination or other non lethal methods to control the disease reservoir in wildlife. Professor Rosie Woodroffe at the Institute of Zoology, who ran the Randomised Badger Culling Trials in 2007, thinks the report is mostly a good thing. She praises the advice to find alternatives to killing British wildlife, but explains to Adam Rutherford that trialling vaccinations for badgers after culling could be problematic. Monitoring the health of estuarine and coastal water ecosystems usually relies on the expensive and time-consuming practice of catching fish to get a view on the health of entire ecosystem. New methods are starting to be used called Environmental DNA sampling, using DNA barcoding techniques. As everything sheds fragments of DNA into the environment, by sampling water or sediment, you can use High Throughput DNA analysis, using special probes to pull out and identify the species you want. It’s a lot quicker and cheaper, but you still have to deal with problems of collection, filtration and contamination. But Professor of Conservation Genetics, Stefano Mariani at the University of Salford, has found an even better way. He's recruited the European brown Shrimp, which eat everything, are found everywhere and can do all the filtering and storing of the DNA for him. All Stefano has to do is catch the shrimp and analyse their stomach contents to get a picture of what is in the environment.PhD student at Sheffield University, Rory Cooper explains to Adam how mathematical patterns that Alan Turing worked on late in his career are found in abundance in the natural world. The genetic mechanisms of switching on cellular processes that lead to feather or hair emergence have now been found in the formation of shark scales. The pattern relies on genes to switch on a function, such as feathering, but diffuse out to surrounding cells and switch the function off, leading to a uniform, spaced out pattern. As shark species split off from other vertebrates around 420 million years ago, it therefore proves that Turing’s pattern is recycled through other vertebrates. Producer: Fiona Roberts

15 Marras 201830min

What could be the oldest figurative cave paintings in the world have been found in a cave complex in remote Borneo. A reddish orange depiction of an animal that could be a Banteng (wild cattle found in the region) is at least 40,000 years old. Humans are now the greatest force in shaping the surface of the Earth. We now move more than 24 times as much rock, rubble and sediment than all the world’s rivers. Dr Anthony Cooper of the British Geological Society has been weighing this anthropogenic global force. Closer to home, Adam Rutherford speaks to Professor Colin Waters at the University of Leicester, about the weight of human-created rubble he’s found under the City of London. When the new polymer £50 note is introduced in around a year’s time, it’ll have a scientist on the reverse. Industrialist Matthew Boulton and engineer James Watt will step aside for a British scientist nominated by the public. Sarah John, Chief Cashier at the Bank of England, explains the rules to Adam and science experts, Emily Grossman and Alice Bell debate the merits of some of the more popular front runners.

8 Marras 201829min

Potholes are one of the biggest frustrations to any road-user, but why do they keep occurring? Following Philip Hammond’s announcement of £420 million for councils to tackle potholes, Malcolm Simms, Director of the Mineral Products Association’s Asphalt & Pavement group, explains how potholes form and why they continue to occur. Alvaro Hernandez of Nottingham University chats to Marnie about new solutions he is investigating to improve our roads and reduce the number of potholes. Roland Pease meets John Able and Professor Simon Potts, to discuss the value of ‘big data’ – in this case, for honeybees. Using a ‘buzz box’ to detect conditions inside and out of the beehive, this data can be transmitted to the cloud and used to keep track of beehive health. This is termed the ‘internet of hives’ and provides a huge amount of high quality data to discover the key indicators of beehive health. Back in the 1980s, the world discovered that CFCs were destroying the ozone layer, which protects the earth, and us, from being fried by the sun’s rays. The 1987 Montreal Protocol banned the use of CFCs, and as we stopped emitting them, the ozone layer started to recover. But there are other gases like carbon tetrachloride that destroy the ozone layer and are also restricted. But Dr Matt Rigby, an atmospheric chemist from Bristol University, has been discovering that there are still sources of carbon tetrachloride. Testing for illicit drugs usually needs a blood or urine sample, but now it can be done from a sweaty fingerprint. And not only on a living suspect, but on a corpse. Adam Rutherford speaks to the developer of this smart chemistry , University of East Anglia’s David Russell.

1 Marras 201828min

How might Brexit affect UK Science? Why is feeding a 'last resort' antibiotic to farm animals not a good idea? Why is space probe Bepicolombo going to Mercury? Adam Rutherford is your host.This week, leading British and European scientists wrote to the British Prime Minister and European Commission President. They expressed their concerns about the potential impact if there is a no-deal departure by the UK from the European Union. We hear from one of the signatories Professor Venki Ramakrishnan, President of the Royal Society and from UK Science Minister Sam Gyimah.Roland Pease reports on the use of the medically valuable last-resort antibiotic, colistin, as a growth promoting substance in agricultural livestock feed in India. He speaks to infectious disease consultant Abdul Ghafur in Chennai, India and microbiologist Tim Walsh at Cardiff University.The space probe Bepicolombo has begun its 7 year voyage to the planet Mercury. Suzie Imber of the University of Leicester and David Rothery of the Open University tell Adam why the journey will take so long and why Mercury is such an intriguing planet, worthy of exploration by this new probe.

25 Loka 201827min

How far back can we trace the ancestry of dogs? For just how long have they been following us around? The answer is for a very long time - long before humans settled down and developed societies. Scientists in France have been looking at ancient dog DNA to try and work out whether people tamed and domesticated local dogs as they migrated across the planet, or brought dogs with them. The answer tells us much about the relationship - or rather lack of it, between early farmers and the hunter gathers they replaced throughout Europe. And how many Bosons can you fit in a rocket? As they are rather small particles the answer will be quite a lot, but a team from Germany has succeeded in making a form of mater known as the Bose Einstein Condensate in a small rocket which they launched into the Earth’s upper atmosphere. Potentially the success of their experiment could lead to new ways of detecting gravitational waves in space. Back on earth a group of ‘A’ level students have been looking at or rather listening to data from space, and published a scientific paper on their observation of a solar storm. In a unique partnership with university physics researchers, information on electromagnetic waves around our planet has been turned into audible data. The keen ears of the students identified events that had not previously been detected. And how incriminating is your washing machine? Digital forensics, the unpicking of the data trails on our digital devices, from phones to TV tuners, even baby monitors and washing machines are now playing a part in criminal investigations, not just cases involving online fraud or cybercrime, but any investigation looking at what suspects were doing and when. A digital trail can act as evidence for time and place.

18 Loka 201828min

Adam Rutherford speaks to Dr Tamsin Edwards, a lecturer in Physical Geography at Kings College London and a lead author for the latest IPCC report. Dr Edwards describes what happens in the making of the report, including the summarising of the wealth of scientific literature available into an understandable document for the policy makers.Cairngorms National Park in Scotland is part of an ambitious project to restore the habitat to its former natural state. Four organisations have joined together as the 'Cairngorms Connect’ project – Scottish Natural Heritage, the Royal Society for the Protection of Birds, Wildland Limited and Forest Enterprise Scotland. Graeme Prest of Forest Enterprise Scotland explains how the project team will start to restore the habitat.The grass pea is a resilient and highly nutritious legume but it contains varying level of toxins. Marnie Chesterton visits the John Innes Centre in Norwich to meet the researchers working on making the grass pea less poisonous, which could aid food security, particularly in sub-Saharan.The Sun is technically a G-type main sequence star, which means it’s a giant continuous nuclear fusion reaction plasma, spewing out extremely dangerous matter and energy in every direction, and when it hits the Earth, this can cause all sorts of problems. Adam visits the Science Museum in London to meet Harry Cliff, a physicist and curator of a new exhibition: ‘The Sun: Living With Our Star’, which explores our relationship with the closest star to earth. Adam also finds out from Professor Chris Scott of Reading University about a citizen science project called Protect our Planet from Solar Storms.

11 Loka 201827min