349: Oxidized rNTPs and Transcription Fidelity: How 8‑oxo‑rGTP Embeds RNA Damage
Hou P et al., PNAS - This study combines kinetic assays and X‑ray crystallography to show how 8‑oxo‑guanosine triphosphate (8‑oxo‑rGTP) is incorporated by RNA polymerase II and how its pairing geometr...
24 Huhti 21min
348: v96: A 96-mutation plasma DNA test to track residual AML through transplant
Wang Y et al et al., PNAS - This episode covers a PNAS study describing v96, a personalized plasma cell-free DNA assay that tracks up to 96 patient-specific mutations to sensitively quantify measurabl...
21 Huhti 23min
347: Diffusive spreading across dynamic mitochondrial network architectures
Holta KB et al., Proceedings of the National Academy of Sciences (PNAS) - This episode explains a quantitative framework for diffusion on spatially embedded dynamic mitochondrial networks. The study c...
19 Huhti 23min
346: Palindromes and RNA Self-Recognition
Kimchi O et al., PNAS - This computational study shows that self-complementary RNA regions (palindromes) can drive sequence-specific homotypic clustering by enabling multivalent intermolecular base pa...
19 Huhti 23min
345: Genes of Prosody: Rhythm, Music, and Reading
Scartozzi AC et al., Human Genetics and Genomics Advances - This episode reviews a GWAS of speech rhythm (prosody) perception using the TOPsy task (n≈1,501 European-ancestry), reporting 14 suggestive ...
17 Huhti 25min
344: Homozygous TNNI3 p.Arg136* and severe pediatric restrictive cardiomyopathy
Kühnisch J et al., Human Genetics and Genomics Advances 7, 100598 (2026) - Case report and tissue analysis linking a homozygous TNNI3 nonsense variant (c.406C>T; p.Arg136*) to early-onset, treatment-r...
17 Huhti 23min
343: From Cats to Dogs: The Parvovirus Host Jump
López-Astacio RA et al., PNAS - Analysis of 60 years of feline panleukopenia virus genomes traces the origins of canine parvovirus, identifies vaccine-derived sequences, and documents distinct evoluti...
15 Huhti 13min
342: Modular MPRA Reveals Context-Dependent Regulation at T2D Loci
Tovar A et al., Human Genetics and Genomics Advances - This episode examines a study that used a modular MPRA to test ~11,656 genomic fragments from T2D- and metabolic trait-associated regions in panc...
14 Huhti 17min
