249: PCM1 links centrosome asymmetry to endosome dynamics
Zhao X et al., Nature Communications - In developing neural progenitors PCM1 localizes to the mother centrosome and to Notch ligand-containing endosomes, promoting Par-3/dynein assembly and Rab5-to-Ra...
4 Tammi 20min
248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation
Kutchukian C et al., Nature Communications - Disruption of the PIKfyve/Fig4/Vac14 complex drives ULK1-dependent trafficking of PI4KIIα and ATG9A to lysosomes, elevating lysosomal PI(4)P to promote mem...
3 Tammi 21min
247: Genome graphs reveal structural variation in M. tuberculosis
Canalda-Baltrons A et al., Nature Communications - Long-read assemblies and a pangenome reference graph uncover widespread structural variants that shape Mycobacterium tuberculosis evolution and contr...
2 Tammi 21min
246: SV2A structural pharmacology and allosteric occlusion
Pidathala S et al., Nature Communications - High-resolution cryo-EM structures of human SV2A reveal that orthosteric ligands induce an occluded MFS conformation and a secondary allosteric pocket modul...
1 Tammi 16min
245: Benchmarking DNA foundation models
Feng H et al., Nat Commun - A comprehensive, unbiased benchmark compares five DNA foundation models across 57 datasets and multiple tasks, finding mean token embeddings improve classification and that...
31 Joulu 202519min
244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis
Sun Z et al., Nature Communications - Mitochondrial NEK7 is imported via MTS peptides, binds SDHB to stabilize complex II conformation, prevent reverse electron transport and ROS, and thereby protects...
30 Joulu 202517min
243: Genome-wide UVB GxE study finds 162 vitamin D variants
Shraim R et al., Nat Commun - A GWIS of 338,977 UK Biobank White British participants using a cumulative weighted ambient UVB measure identified 307 independent loci for 25-hydroxyvitamin D, including...
29 Joulu 202517min
242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats
Godin P et al., Nature Communications - A single intramuscular injection of an AAV9 vector encoding feline anti‑Müllerian hormone (fcMISv2) in prepubertal kittens produced sustained supraphysiological...
28 Joulu 202517min
