374: DNA-guided Cas12a reprogrammed to target RNA
Wu X et al., Nature Biotechnology - The authors engineer synthetic PAM-containing DNA guides (crDNA) that bind Cas12a to form a deoxyribonucleoprotein (DNP) complex that recognizes and cleaves complem...
22 Touko 20min
373: Base by Base 373 — A ciliate rewrites UAA and UAG
McGowan J et al., PLOS Genetics - Genome and transcriptome sequencing of an uncultured Oligohymenophorea ciliate (PL0344) reveals a novel nuclear genetic code in which UAA translates as lysine and UAG...
21 Touko 21min
372: Genes, IQ and Socioeconomic Outcomes in Emerging Adults
Kajonius PJ et al., Scientific Reports - This episode examines a twin-study analysis from the German TwinLife panel showing that cognitive ability at age 23 predicts socioeconomic status at age 27, an...
20 Touko 24min
371: Glial epigenomic dysregulation and genetic risk in tauopathies
Han et al., Nature Communications - This study uses paired single-nucleus chromatin accessibility and gene expression profiling across Alzheimer’s disease, Pick’s disease and progressive supranuclear ...
19 Touko 26min
370: ICMT and INPP5E enable BRAFV600E tumor growth
Yang X et al., Proceedings of the National Academy of Sciences - Genetic and pharmacologic inhibition of ICMT suppresses proliferation, invasion, and tumor growth in BRAFV600E-driven models and identi...
18 Touko 23min
369: NEK2 drives EBV-positive NHL pathogenesis
White MC et al., PNAS - This episode reviews a PNAS study showing that the kinase NEK2 is upregulated by EBV and its latency proteins and that NEK2 inhibition with the irreversible inhibitor JH295 sel...
16 Touko 24min
368: PARP1 and Amyloid: Protecting Neurons in a Familial AD Model
Jhaldiyal A et al., PNAS - This episode summarizes a PNAS study showing that PARP1 activation links Aβ1-42 toxicity to DNA damage, amyloid accumulation, neuroinflammation, and cognitive deficits, and ...
16 Touko 26min
367: Ancestral Splice Variation Fuels Cichlid Jaw Diversification
Singh P et al., PNAS - This paper compares alternative splicing (AS) and gene expression (GE) across 200 transcriptomes from oral and pharyngeal jaws of 18 haplochromine cichlid species across Lakes V...
15 Touko 22min
