From First Principles

From First Principles

From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.

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Jaksot(52)

Artemis II, Claude Code Leak, iPhone Spyware & Project Hail Mary (EP 36)

Artemis II, Claude Code Leak, iPhone Spyware & Project Hail Mary (EP 36)

Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers five new science and tech stories at a high level: NASA’s Artemis 2 moon mission, what actually leaked in the Claude Code incid...

3 Huhti 1h 1min

Can AI Help Wake Coma Patients? The Science of Consciousness (EP 35)

Can AI Help Wake Coma Patients? The Science of Consciousness (EP 35)

Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the hardest questions in neuroscience: what breaks in the brain during a coma, and can we figure out how to turn co...

31 Maalis 1h 8min

AI Cancer Vaccines, Strange Fish, Ketamine, and Ancient Life (EP. 34)

AI Cancer Vaccines, Strange Fish, Ketamine, and Ancient Life (EP. 34)

Hosted by Lester Nare and Krishna Choudhary, this episode is a fast-moving science rundown covering four remarkable stories from across AI, genetics, neuroscience, and paleontology. We dig into the st...

27 Maalis 44min

Can Human Neurons Really Play Doom? The Science Behind Wetware (EP. 33)

Can Human Neurons Really Play Doom? The Science Behind Wetware (EP. 33)

Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into one of the strangest science stories of the year: a dish of human neurons allegedly learning to play Doom. We go back to t...

24 Maalis 1h 13min

5,000-Year-Old Bacteria, Solar Storms, Dogs, and Meta’s AI War (EP. 32)

5,000-Year-Old Bacteria, Solar Storms, Dogs, and Meta’s AI War (EP. 32)

Hosted by Lester Nare and Krishna Choudhary, this is our first standalone rundown episode — a faster, looser format where we hit several stories we didn’t have room to turn into full deep dives. This ...

20 Maalis 38min

Optovolution: Teaching Proteins to Think Like Computers (EP. 31)

Optovolution: Teaching Proteins to Think Like Computers (EP. 31)

Hosted by Lester Nare and Krishna Choudhary, this episode is a deep dive into a new synthetic-biology breakthrough out of EPFL: OptoEvolution. The big idea is simple but powerful — traditional directe...

18 Maalis 55min

Can We Stop an Asteroid? The Physics Behind NASA’s DART Mission (EP. 30)

Can We Stop an Asteroid? The Physics Behind NASA’s DART Mission (EP. 30)

Hosted by Lester Nare and Krishna Choudhary, this episode is a full deep dive on planetary defense. We break down NASA’s DART mission, why the goal was never to “blow up” an asteroid but to gently nud...

16 Maalis 54min

Astrobiology’s Biggest Survival Test + A Vaccine Against Everything? (EP. 29)

Astrobiology’s Biggest Survival Test + A Vaccine Against Everything? (EP. 29)

Hosted by Lester Nare and Krishna Choudhary, this episode starts in astrobiology with a fresh experimental challenge to one of the biggest objections to lithopanspermia: can life actually survive the ...

12 Maalis 2h 4min

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