
Episode #177: Healthy Living Uncovered - From Nutrition Hacks to Aging Well
Ever wondered what travel can do to your gut? In this bonus episode of the Biohacking Superhuman podcast, we shed light on the impact of frequent travel on our microbiomes and stress the importance of maintaining balance. Neglecting this balance can wreak havoc on our gut health, so we've incorporated various tools to help keep our microbiomes in check. We also delve into the world of GLP-1 agonists and highlight the significance of adequate protein intake for muscle mass maintenance. The episode wraps up with our favorite dietary strategies and supplements. We reveal the strategies that have worked for us, and how these could potentially help you on your journey to optimal health and aging gracefully. Dr. Amie Hornaman “The Thyroid-Fixer”, is host to the top-rated podcast in medicine and alternative health: The Thyroid Fixer™, with listeners around the globe. She is the founder of The Institute for Thyroid and Hormone Optimization, an organization with transformational, proven approaches to address thyroid dysfunction and support people in returning to full health. Dr. Amie is also the creator of The Fixxr™ Supplement line with revolutionary, proprietary supplements that are changing the lives of many people. Thank you to our sponsors for making this episode possible: Apollo: Go to apolloneuro.com/nat and use code NAT50 to save $50. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Dr. Amie Hornaman: Website: https://dramiehornaman.com/en-ca Instagram: https://www.instagram.com/dramiehornaman/ What we discuss: (0:00:03) - In-Depth Discussion on Nutrition and Health (0:07:14) - Travel's Impact on the Microbiome (0:17:38) - Managing PCOS, Diabetes, and Muscle Building (0:23:00) - GLP1 Agonist and Muscle Loss Effects (0:36:13) - Supplement Protocols and Dietary Strategies (0:49:44) - Optimal Health and Aging Strategies
22 Syys 20231h 3min

Episode #176: Unlocking Longevity: The Life-Extending Properties of Rapamycin with Dr. Ross Pelton
Can you imagine unlocking the secret to longevity through a powerful compound discovered on a remote island? In this episode of the Biohacking Superhuman Podcast, we chat with Dr. Ross Pelton, a renowned scientist and author, about rapamycin, a compound with untold potential for revolutionizing health and extending life. Together, we trace rapamycin’s fascinating history from its origins on Easter Island to its current potential as an awe-inspiring life-extending compound, delving into its dual mechanisms - mTOR and autophagy - for a fresh outlook on cellular metabolism and the aging process. The intricate balance between mTOR and autophagy plays a pivotal role in achieving healthy longevity - a balance that our ancestors maintained effortlessly due to their lifestyle but has been upset by our modern way of living. With Dr. Pelton, we'll explore how to restore this equilibrium through intermittent fasting, exercise, a healthy diet, and of course, rapamycin. We also discuss the importance of dosing, frequency of use, and the intriguing concept of "rectangularization of the aging curve." Ross Pelton is a pharmacist, nutritionist, author and a health educator who is widely recognized as the world’s leading authority on drug-induced nutrient depletions. He was named one of the top 50 most influential pharmacists in the United States by American Druggist magazine for his work in Natural Medicine. Visit https://theantiaging.store/product/rapa-pro-rapamycin/ and use code longevity15 to save on your first order. Thank you to our sponsors for making this episode possible: BiOptimizers: Use code bionat10 at magbreakthrough.com/bionat Paleovalley: Visit www.paleovalley.com/nathalie - no code needed Berkley Life: Use code NIDDBL at www.berkeleylife.com Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Dr. Pelton: Website: https://www.naturalpharmacist.net/ Book: https://www.amazon.ca/Rapamycin-mTOR-Autophagy-Treating-Syndrome/dp/1607660156 What we discuss: (0:00:03) - About Rapamycin (0:13:03) - Balancing mTOR and Autophagy Importance (0:19:38) - Rapamycin, Fasting, and the Microbiome (0:32:32) - Rapamycin Dosage and Monitoring (0:40:46) - Benefits of Rapamycin for Aging (0:47:43) - Dietary Factors in Protein and Rappamycin (0:58:32) - Postbiotic Metabolites and Gut Health (1:08:22) - Plant-Based Diet and Probiotics for Microbiome (1:16:03) - Japanese Fermentation and Gut Microbiome Key takeaways: Rapamycin has the potential to be life-saving due to its two powerful mechanisms: mTOR and autophagy. It was discovered on Easter Island in 1966 and approved for kidney transplant patients in 1996 by the FDA. It has potential as a revolutionary new type of chemotherapy and can be used to better understand cellular metabolism and the aging process. When it comes to achieving healthy longevity, balance between mTOR and autophagy is essential. Our ancestral humans achieved this naturally due to their lifestyle of eating once a day, spending four hours digesting their food, and sometimes going two or three days without nutrient intake. But today, food is available all the time, leading to an over-activation of mTOR and a lack of autophagy. To restore the balance, intermittent fasting, rapamycin, exercise, and eating healthy are advocated. When it comes to rapamycin, it's important to remember that it won't override bad habits and it's not a miracle quick fix. To gain the full benefits, a reasonable diet, exercise, and sleep regularly are necessary.
19 Syys 20231h 18min

Episode #175: Dr. Bruce Hoffman: Demystifying Mast Cell Activation Syndrome
Could you imagine a condition that affects virtually every organ, eludes the standard diagnostic criteria, and causes multi-system inflammation? Meet the perplexing world of mast cell activation syndrome (MCAS). MCAS is an elusive condition that affects many, yet remains largely misunderstood. MCAS is a syndrome that triggers multi-system inflammation, and due to its diverse range of symptoms, it often eludes typical diagnostic processes. It has a profound impact on both the body and mind. Mast cells are integral to our innate immune system, playing a crucial role in safeguarding us against foreign invaders, allergens, and environmental toxins. However, potential triggers of mast cell hyperactivity can range from environmental toxins to mold. Today I’m with Dr. Bruce Hoffman and we dissect this complex condition and delve into the critical role of mast cells in our immune system. Learn how mast cells, our body's fierce protectors against toxins, might turn hyperactive due to triggers like environmental toxins, heavy metals, or mold, launching a cell danger response that could send your body into a protective shutdown. The conversation takes a deeper turn as we explore the intersection of physical and mental health. Focusing on those battling MCAS and early developmental trauma, Dr. Hoffman shares invaluable self-regulation strategies and lends insight into the significance of neurofeedback and building a window of tolerance. Dr. Hoffman is board-certified and has a fellowship in anti-aging medicine as well as a Master’s degree in clinical nutrition. He is also a certified functional medicine practitioner. In addition to his clinical training, Dr. Hoffman has studied with many of the leading mind-body and spiritual healers of our times, including Deepak Chopra, Paul Lowe, Osho, Ramesh Balsekar, and Jon Kabat-Zinn. He has shared the stage with Dr. Deepak Chopra, Dr. John F. Demartini, and he continues to spread his inspiring vision of healing and wellness with audiences and patients around the world. Thank you to our sponsors for making this episode possible: Mitopure: Use code NAT10 for 10% your order at https://www.timelinenutrition.com/shop/nutrition LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: www.NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Dr. Bruce Hoffman: Website: https://hoffmancentre.com/ What we discuss: (0:03:00) - Understanding Mast Cell Activation Syndrome (0:15:27) - Treating Physical and Mental Health Impacts (0:23:09) - Understanding and Healing Unconscious Dynamics (0:38:05) - Treatment and Management of Histamine Intolerance (0:45:12) - Building Resilience and Shifting Healthcare Paradigms (0:57:19) - New Health Curriculum for Transformation Key takeaways: Mast Cell Activation Syndrome (MCAS) is a condition where mast cells, a component of our immune system, become hyperactive and trigger inflammation across multiple systems in the body. This can result in a wide range of symptoms and can be difficult to diagnose. Potential triggers of this hyperactivity can include environmental toxins, mold, and certain foods. Physical and mental health are interconnected when it comes to MCAS. Individuals with this syndrome may have early developmental trauma which can exacerbate symptoms. Learning self-regulation techniques, such as neurofeedback, can be beneficial for managing stress and promoting balance in the body and mind. The treatment and management of MCAS is complex and often involves a combination of nutraceuticals and pharmaceuticals, dietary adjustments, and the creation of a neutral environment. Continuous vigilance is necessary to avoid triggers and manage the condition effectively. It is crucial to build resilience against environmental toxins and to focus on overall well-being.
12 Syys 20231h 13min

Episode #174: Discover the Lifestyle Diet That Suits You Best
As a nutritionist, I’ve always been fascinated by food and the power of food to heal our bodies. Over the last couple of years, the rhetoric around diets has been heating up–from keto to paleo to vegan, vegetarian, and now even carnivore. Diets are just lifestyles, so what is best? Today I’m exploring this hot topic and sharing tips for adopting a new lifestyle or thinking about a new lifestyle and then applying it. Do your homework before making a dramatic diet change. It's vital to collect data about your health and I discuss the importance of baseline tests and how to measure and monitor your progress when changing dietary lifestyles. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: https://www.NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 What we discuss: 11:14 - Discussion on Vegan and Carnivore Diets 20:17 - Baseline Testing for a Lifestyle Change 25:54 - Importance of Proper Guidance in Dietary Approaches 30:27 - Committing to Dietary Changes 35:58 - Optimal Diets and Lifestyle for Longevity Key takeaways: There's not a one-size-fits-all approach when it comes to diet and nutrition. Dietary choices should be based on personal health status, lifestyle, and genetic makeup rather than blindly following popular trends or extreme diets. It’s important to test and collect data when making a diet change. It's advised to do blood work, assess micronutrient status, and examine the gut microbiome to get a clear picture of one's starting point. Monitoring body composition, such as getting a DEXA scan, is also suggested to measure progress. Long-term health and longevity are complex and cannot be solely attributed to a single dietary choice. Other lifestyle factors such as caloric restriction, periods of fasting, regular physical activity, and stress management are also crucial for promoting longevity.
8 Syys 202343min

Episode #173: Victor Sagalovsky: The Healing Benefits of Deuterium-Depleted Water
Have you ever heard of heavy water? In this episode of the Biohacking Superhuman Performance podcast, I chat with Victor Sagalovsky, Co-Founder and CEO of Litewater Scientific, about deuterium-depleted water. Deuterium is a naturally occurring isotope of hydrogen that has an extra neutron in its nucleus, making it twice as heavy as ordinary hydrogen, thus where it got its name of heavy water. Studies suggest that reducing deuterium levels in the body can have positive effects on various biological processes, such as improved cellular function, enhanced energy production, increased support of the immune system, and potential anti-aging properties. Victor also shares how much deuterium we should have in our bodies, how long it takes to see results from drinking deuterium-depleted water, and who is most likely to experience the biggest shift in their health from intaking heavy water. Victor Sagalovsky is the co-founder and CEO of Litewater Scientific, the first and only super deuterium-depleted light water, where he has dedicated himself to the research, development, and production of this rare water. Victor has researched and studied the benefits of deuterium-depleted water through his theory entitled Endogenous Radiation Damage Theory of Aging. It proposes that our biggest obstacle to longevity is the excess deuterium and other damaging isotopes on the planet and proper mitigation will radically extend our lifespans. Thank you to our sponsors for making this episode possible: Litewater : Use code NAT10 to save 10% at https://bit.ly/41BT7sR Restoracell: Use code NAT25 at https://www.vitaliskincare.com/ Berkeley Life: Use code NIDDBL for 10% off at berkeleylife.com LVLUP: Use code NAT10 to save 10% off at https://lvluphealth.com/ Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20-Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Victor Sagalovsky: Website: https://www.drinklitewater.com/ Instagram: https://www.instagram.com/drinklitewater/ What we discuss: 02:16: What is deuterium-depleted water? 05:56: How do carbs affect deuterium levels in the body? 10:55: Who discovered the effect of deuterium? 17:16: What are the kinetics of deuterium water? 20:34: How long does it take to see results? 24:44: How does hydrogen interact with deuterium? 31:25: How does structured water compare to deuterium water? 35:25: Is Litewater structured? 36:38: How much deuterium should we have in our bodies? 43:51: Who would experience the biggest shift when intaking deuterium-depleted water? 56:35: Where to learn more about Victor and Litewater? Key takeaways: Deuterium is a naturally occurring isotope of hydrogen that has an extra neutron in its nucleus, making it twice as heavy as ordinary hydrogen, thus where it got its name of heavy water. Deuterium-depleted water is considered to be a huge factor in why certain people get to live past 100 years old. Not only does it improve mitochondrial function, but it also helps reduced oxidative stress, enhance cellular repair, and regulate hormones that influence aging and lifespan. Deuterium mainly affects mitochondrial function, which plays a crucial role in energy production by generating adenosine triphosphate (ATP). This is because deuterium has a larger mass compared to hydrogen, which can influence the rates of enzymatic reactions occurring in the mitochondria. High levels of deuterium in the mitochondria can also disrupt the balance of cellular redox reactions and potentially impact mitochondrial function.
5 Syys 20231h 9min

Episode #172: Wizard Sciences: Biohacking for Peak Performance with C60
What if your body could perform at superhuman levels using the power of science? The exploration of carbon 60's potential as a biohack for peak human performance presents an exciting frontier in health and wellness. This episode dives into the astounding world of Carbon 60 - a unique carbon allotrope that has the potential to push human performance to unprecedented heights. Today I’m with Ian Mitchell, founder of Wizard Sciences, who created a world-class health and wellness research and development company. Our conversation dives into the remarkable properties of Carbon 60, investigating its role in reducing oxidative stress, increasing ATP production, detoxifying the body, inhibiting lipid peroxidation, and preventing rancidity. We delve into C60’s exciting emergence as a supplement, accompanied by Mitchell's groundbreaking innovations like Wizard Water, a hyper-oxygenated drink that has the potential in improving oxygenation and decreasing muscle fatigue. We also discuss the profound science behind waveform dynamics and quantum charging cells, as well as protocols to ensure carbon 60 is used beneficially and not as a detriment. As a research scientist and pharmaceutical consultant, Ian is Chief Science Officer at Redbud Brands and at HigherDOSE. He is Chief Science Advisor at Leela Quantum and is Scientific Advisor at Satori Neuro. Ian is also Polymath in Residence at Ecliptic Capital. Thank you to our sponsors for making this episode possible: Wizard Sciences: Visit wizardsciences.com. Use code NAT15 at checkout for 15% discount. Mitopure: Go to timelinenutrition.com/NAT10 and use code NAT10 to get 10% off your order. LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/. Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Ian Mitchell: Website: https://wizardsciences.com/ Instagram: @wizardsciences What we discuss: (0:07:10) - Effects of C60 (0:17:05) - Overcoming Injury With Resilience and Gratitude (0:22:14) - Carbon 60 and Healing Potential (0:28:24) - Quantum Waveform Dynamics and Allergic Reactions (0:35:39) - Carbon 60 and Its Effects Discussion (0:40:24) - Carbon 60 and Performance Enhancement (0:49:56) - Benefits of Olympic and Neural RX (1:02:32) - Exploring Brain-Boosting Formulas (1:06:32) - Exploring Science, Improving Human Performance
29 Elo 20231h 26min

Episode #171: Autumn Smith: Rewriting the Narrative of Animal Protein
Ready to challenge the current beliefs about meat consumption? There are current narratives that have demonized meat, explicating the healing powers of grass-fed pasture-raised meats for both our bodies and the planet. Today we’re debunking myths and misconceptions about meat consumption and its environmental impact. I’m joined by Autumn Smith, and we’re discussing the potential of regenerative farming techniques, compared to conventionally raised beef. We navigate through the arguments against beef consumption and Autumn sheds light on how regenerative farming could be scaled to meet the needs of a growing population. We also discuss the critical role of humane treatment of animals in our food choices and reflect on our obligation as omnivores to respect the natural cycle of life. Autumn Smith is the co-founder of Wild Pastures and Paleovalley, a company dedicated to helping people get the essential nutrients they need without added sugars, grains, or other harmful ingredients. She holds a Master of Science in Holistic Nutrition and is a Functional Diagnostic Nutrition Practitioner. She is also a certified eating psychology coach by the Institute of the Psychology of Eating and Soil Advocacy and is a doctoral candidate. Thank you to our sponsors for making this episode possible: Paleovalley: Use the link paleovalley.com/nathalie for 15% off. Restoracell: Use code NAT25 at https://www.vitaliskincare.com/ Healthgevity: Visit https://healthgev.com and use code LONGEVITY Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Autumn Smith: Website: Paleovalley.com Instagram: @paleovalley Link: paleovalley.com/promos/nathalie - 15% off (no code needed) What we discuss: (0:08:00) - Regenerative agriculture compared to conventionally raised meat (0:13:00) - What is regenerative farming (0:15:36) - Misconception of livestock environmental impact (0:20:15) - Regenerative farming techniques for scale (0:25:13) - Arguments against consuming animal products (0:28:00) - Narrative of consuming animal products (0:35:47) - How eating animal products impacts health (0:43:59) - Research of grain-fed beef, grass-fed beef, and plant-based meat, and their impact on human health. (0:48:10) - Nutrients in food (0:53:17) - Negatives of meat (0:57:41) - Beliefs and science of meat consumption (1:02:54) - Organ meats Key Takeaways: Conventional meat production, which is largely based on factory farming, is not sustainable due to its environmental impacts. Regenerative agriculture, on the other hand, uses animals in a more sustainable way by working with nature rather than against it. This results in healthier soil, more nutrient-dense food, and the potential to sequester carbon. There is a common misconception that meat is a major cause of disease. However, the real dietary villains are sugar, carbohydrates, and processed foods. Animal products are our most nutrient-dense foods, but the quality and source of the meat you consume matters significantly. Grass-fed, pasture-raised meat has significant health benefits and is better for the environment than grain-fed, factory-farmed meat. Traditional diets often incorporated organ meats, suggesting that they have long been recognized for their nutritional benefits. Consuming organ meats, such as heart, liver, kidney, and spleen, can be beneficial for their nutrient profile, which includes zinc, iron, B12, and vitamin A.
25 Elo 20231h 14min

Episode #170: Dr. Dale Bredesen: An In-Depth Understanding of Alzheimer's Disease
In recent years, there has been a significant change in how we approach and address diseases. Previously, the responsibility of maintaining good health largely relied on the healthcare system. However, this mindset has shifted, and individuals are now encouraged to play an active role in advocating for their own health. Understanding the biochemical processes that contribute to illnesses, such as Alzheimer's, has become crucial in managing and taking control of our personal health journey. By recognizing the intricate mechanisms that lead to diseases like Alzheimer's, we can make more informed decisions regarding our lifestyle choices, medical interventions, and preventative measures. I’m joined by Dr. Dale Bredesen, and we’re diving into the intricacies of Alzheimer's, its prevention, and even reversal possibilities. We cover the crucial role of the immune system in both Alzheimer's and COVID, and the fascinating connections between these diseases. Dr. Bredesen also discusses his lab's ground-breaking work to understand the neurodegenerative process, which has resulted in three books and thousands of people experiencing improvements in their conditions. Dale E. Bredesen, M.D., is internationally recognized as an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease, and the author of the New York Times bestsellers The End of Alzheimer's (Avery, 2017) and The End of Alzheimer's Program (Avery, 2020), as well as The First Survivors of Alzheimer’s (Avery, 2021). He has held faculty positions at UC San Francisco, UCLA, and the University of California San Diego, and directed the Program on Aging at the Burnham Institute before coming to the Buck Institute for Research on Aging in 1998 as its founding president and CEO. He is currently a professor at UCLA. Thank you to our sponsors for making this episode possible: Mitopure: Use code NAT10 for 10% your order at https://www.timelinenutrition.com/shop/nutrition. Neurohacker Collective: https://bit.ly/QNHNat and use code NN15 Paleo Valley: Use the link paleovalley.com/nathalie for 15% off Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08 Find more from Dr. Dale Bredesen: Website: https://www.apollohealthco.com/dr-bredesen/ Instagram: @drdalebredesen Twitter: @drdalebredesen What we discuss: (0:00:03) - Shifting paradigms in 21st century medicine (0:15:48) - Addressing toxins and pathogens (0:24:38) - Understanding cognitive decline and prevention (0:28:07) - Alzheimer's disease and treatment (0:34:33) - The APOE4 gene and Alzheimer's risk (0:52:24) - Immune memory, fats, alcohol, and Alzheimer's subtypes (1:06:30) - Accessing Dr. Bredesen's resources and books Key Takeaways: The first step in assessing cognitive decline involves a series of blood and urine tests. These tests are comprehensive and not typically performed by most doctors. They examine various factors that contribute to cognitive decline, such as ongoing inflammation, toxin levels, and metabolism. Additionally, the tests also cover factors like sleep apnea, as reduced oxygenation during sleep can negatively impact brain health. If an individual has zero copies of the APOE4 gene, their lifetime risk for developing Alzheimer's disease is approximately 9%. While this risk is not zero, it is not considered significantly high. On the other hand, individuals with a single copy of the APOE4 gene have a much higher lifetime risk of around 30% for developing Alzheimer's. Those with two copies of the gene have an even greater risk of about 70%, suggesting that a majority of them will likely develop Alzheimer's during their lifetime. There is an interesting phenomenon associated with receiving certain vaccines early in life, such as the BCG vaccine, which has been shown to reduce the risk of Alzheimer's disease. It appears that preparing the adaptive immune system at an early stage may be beneficial. On the contrary, when the innate immune system is modified later in life through late vaccinations, boosters, or exposure to substances like beta-glucans, it can potentially elevate the activity of the innate system again.
22 Elo 20231h 15min