MD Longevity Lab: Playing the Long Game with Drs. Vikas and Nisha Patel25 Des 2025

19. Biological Aging Clocks, mTOR & Rapamycin: A Reality Check with Dr. Matt Kaeberlein

In this episode of MD Longevity Lab: Playing the Long Game, Drs. Nisha and Vikas Patel sit down with world-leading aging researcher Dr. Matt Kaeberlein to cut through the noise in longevity medicine.We discuss why most biological aging clocks fall short, what mTOR actually does, how rapamycin works (and why it’s widely misunderstood), what truly moves the needle for healthspan, and where AI and preventive medicine are headed.This is an evidence-based conversation focused on clarity, nuance, and long-term thinking—without the hype.Topics Covered • Why biological aging clocks are unreliable at the individual level • mTOR explained and its role in aging biology • Rapamycin: risks, benefits, and unknowns • Fasting and caloric restriction myths • What actually improves healthspan (exercise, sleep, connection, hormones) • AI, wearables, and the future of longevity care • The Dog Aging Project and slowing aging in companion animals About Our GuestDr. Matt Kaeberlein, PhD is a world-renowned scientist in the biology of aging, founder of Optispan, and co-founder of the Dog Aging Project. He is known for prioritizing evidence over hype and for advancing translational longevity science.Links & Resources • Follow Dr. Matt Kaeberlein: @mkaeberlein • Optispan & the Optispan Podcast: https://www.optispan.com https://www.dogaginginstitute.org • MD Longevity Lab: https://www.mdlongevitylab.com • Watch on YouTube (MD Longevity Lab Podcast): https://www.youtube.com/@MDLongevityLab Dr. Kaeberlein also hosts the Optispan Podcast, available on YouTube and all major podcast platforms. If you’d like to support his valuable work advancing longevity science in companion animals, donations to the Dog Aging Institute (a 501(c)(3) nonprofit) are tax-deductible and help make this research possible.

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Episoder(33)

33. Your Health Is Their Inheritance: What Happens to Your Kids When You Don't Take Care of Yourself

The longevity space has earned a reputation for being self-absorbed — biohacker bros optimizing their bloodwork while the rest of us live actual lives. In a word: selfish. This episode is the rebuttal...

2 Jul 55min

32. The Muscle Playbook: Preservation, Building, and Progressive Overload

There is more conflicting advice about muscle out there than almost any other topic in fitness — what to eat, how much to lift, how often, how heavy, whether older adults should even be lifting at all...

18 Jun 1h 10min

31. The Evidence-Based Supplement Guide: Cutting Through the $60 Billion Noise

The supplement industry is a $60 billion business with almost no regulatory oversight. Three out of four American adults take at least one. Almost none of them know what's actually in the bottle.In th...

4 Jun 56min

30. The Delay Game: How Health Insurance Abandoned Your Healthcare & Why The Long Game of Prevention Belongs to You

The American health insurance industry is no longer in the business of paying for your healthcare. It is in the business of delaying it — long enough that someone else has to pay. Usually Medicare. Wh...

21 Mai 49min

29. The Statin You Fear vs. The Peptide You Trust: The Credibility Crisis in American Healthcare

This episode is a follow-up and expansion of Vikas's recent piece in STAT News on the same topic.Mention statins at a dinner party and you'll get muscle pain, brain fog, and Big Pharma conspiracies. M...

7 Mai 49min

28. Can You Out-Run Your Cocktail? Exercise, Alcohol, and the Science of Damage Control

Episode Title: Can You Out-Run Your Cocktail? Exercise, Alcohol, and the Science of Damage ControlCan exercise protect you from the damage alcohol does to your body? Drs. Vikas and Nisha Patel break d...

23 Apr 49min

27. GLP-1 Series, Part 2: Muscle Loss, Weight Regain, and the Protocol That Actually Works

The real conversation about GLP-1 medications doesn't end with the prescription. Part 2 is where we get into the uncomfortable truths — the data on muscle loss, the biology of weight regain, the patie...

9 Apr 1h 2min

26. GLP-1 Series, Part 1: The Biology, the Drugs, and Why the Benefits Go Deeper Than the Scale

📝 Free Substack: mdlongevitylab.substack.com🌐 mdlongevitylab.com📸 @mdlongevitylab🎧 Subscribe, leave a 5-star review, and share this episode with one person who needs to hear it.GLP-1 medications a...

26 Mar 52min