#845: How to Use Ketosis for Enhanced Mood, Cognition, and Long-Term Brain Protection — A Practical and Tactical Guide with Dr. Dominic D'Agostino (Plus: Deconstructing Tim’s Latest Keto Experiment)

Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.

This episode is brought to you by:

Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://gusto.com/tim
Seed's DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim
David Protein Bars 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/tim
Coyote the card game, which I co-created with Exploding Kittens: https://coyotegame.com

Timestamps:

[00:00:00] Who is Dominic D'Agostino?
[00:04:37] Ketosis benefits: Quieting the mind, GABA elevation, metabolic psychiatry.
[00:09:24] My Lyme disease story: Pseudo-dementia reversed in 3-4 days of ketosis.
[00:13:50] Spirochetes are glycolytic: Starve the bug, boost the immune response.
[00:19:20] Ketosis and cancer: Slowing glycolytic tumors, enhancing standard care.
[00:20:50] My 18-day keto experiment: Mood stabilization, Alzheimer’s prevention hopes.
[00:23:19] Metabolic memory: Carryover effects and Valter Longo’s fasting mimicking research.
[00:27:11] Intermittent fasting as keto on-ramp: My 2-8 p.m. eating window.
[00:29:15] Dom’s budget keto meal: Canned mackerel, MCT oil, apple cider vinegar.
[00:33:28] My ketone measurement paradox: Feeling sharp at 0.2 mM readings.
[00:36:56] The carburetor analogy: Ketone production vs. utilization explained.
[00:38:43] Breath ketones vs. blood ketones: Better indicator in caloric deficit.
[00:39:47] Gluconeogenesis fears: Fat, fiber, and salt to slow protein absorption.
[00:45:25] The bunless double cheeseburger question: 80 grams of protein in one sitting.
[00:49:03] Post-meal walking and GLUT4 activation: Timing your glucose disposal.
[00:51:02] CGM and ketone monitor limitations: When your devices gaslight you.
[00:58:05] Rabbit starvation and protein-veggie days: Why your body won’t bankroll its own ketosis.
[01:05:44] Alzheimer’s prevention: Biomarkers, B12, hsCRP, and metabolic health.
[01:09:40] My family history: Letrozole, metabolic dysfunction, and rapid cognitive decline.
[01:13:17] Minimum effective dose: 80% of benefits from low-carb Mediterranean.
[01:18:56] One week per month protocol: Aggressive calorie cut to ramp ketones.
[01:23:12] GKI sweet spot: Target 1-4, aim for 1-2 during intensive weeks.
[01:36:22] Exogenous ketones 101: Palatability, tolerability, pharmacokinetics, toxicity.
[01:39:21] 1,3-Butanediol warnings: Liver toxicity, NAD depletion, dependency risk.
[01:54:22] Intermittent fasting vs. ketogenic breakfast.
[01:59:09] My accidental intoxication story.
[02:03:23] Dr. Veech tribute: Student of Hans Krebs, ketone ester pioneer.
[02:05:08] Fiber on keto: Wild blueberries, broccoli, apples, walnuts.
[02:09:58] The tainted gummies incident: Dom’s forensic investigation underway.
[02:13:08] Thanks to Dr. Boz and Medifoodz.
[02:16:19] Parting thoughts.

For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.

For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsors

Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.

For transcripts of episodes, go to tim.blog/transcripts.

Discover Tim’s books: tim.blog/books.

Follow Tim:

Twitter: twitter.com/tferriss

Instagram: instagram.com/timferriss

YouTube: youtube.com/timferriss

Facebook: facebook.com/timferriss

LinkedIn: linkedin.com/in/timferriss

See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(884)

#880: Relationship Tools That Work — Esther Perel, Brené Brown, Dr. Sue Johnson, Terry Real, and More on Conflict, Repair, and Lasting Love

This episode is devoted to one deceptively simple question: How do you stay close to your partner over time through the inevitable exhaustion, misunderstanding, conflict, disappointment, and change?Th...

19 Aug 57min

#879: How to Reinvent Yourself and Make Bold Moves — Decisive Stories from Matthew McConaughey, Steve Young, Samin Nosrat, and More

This is a special compilation devoted to reinvention: how to shed an identity that no longer fits, decide on a new chapter, navigate uncertainty, and commit to what’s next.This episode is brought to y...

12 Aug 1h 1min

#878: How to Start When You're Stuck, Finish What You Begin, and Stop Waiting for Inspiration — Creative Advice from Elizabeth Gilbert, Seth Godin, Joyce Carol Oates, Anne Lamott and More

This is a special compilation devoted to a subject very close to my heart and currently consuming a large percentage of my waking hours: writing. Over the years, I’ve asked some of the writers I admir...

5 Aug 58min

#877: Q&A with Tim — The Art of Male Friendship, Mini-Retirements, Higher-Resolution Living, Reinvention in The Age of AI, and More

In this wide-ranging Q&A, Tim explores reinvention, enduring skills for the age of AI, friendship, mental health, fitness, language learning, privacy, cognitive longevity, and more.This episode is bro...

29 Jul 1h 15min

#876: Dr. Andrew Huberman — Peptides, Performance, and Protocols

Andrew Huberman, Ph.D., is a neuroscientist and tenured professor in the Departments of Neurobiology and Ophthalmology at Stanford University School of Medicine, where he runs the Huberman Lab. He is ...

22 Jul 2h 14min

#875: The Random Show — Tim and Kevin Talk Retreats, Mortality, AI Predictions, Supplements, Rock Climbing at (Almost) 50, and Not Waiting for “Someday”

In this edition of The Random Show, Tim Ferriss and Kevin Rose reunite over tequila to talk Zen retreats, learning to rock climb at (almost) 50, mortality and grief, why you should stop saying "one da...

16 Jul 1h 58min

#874: Guy Oseary — The Legendary Hollywood Power Broker on 5-Minute Decisions, 36 Years of Managing Madonna, 26 IPOs, and Spotting Magic First

Guy Oseary (@guyoseary) has been spotting talent before anyone else could see it for nearly four decades. Under his leadership at Maverick Records, Maverick sold more than 100 million albums. Guy has ...

7 Jul 1h 32min

#873: David Allen — The Art of Getting Things Done (GTD) (Repost)

For more than 40 years, David Allen has worked with individuals and organizations around the world to help them stay clear, focused, and productive—without burning out. He is the author of the mega-be...

2 Jul 1h 31min