unPAUSED with Dr. Mary Claire Haver18 Nov 2025

GLP-1s and Midlife Metabolism Part 2: Dr. Rocio Salas Whalen Breaks Down the Science of Weight Loss and Menopause

What happens after you lose the weight? Few are focused on this important question about GLP-1 medications. In Part 2 of this conversation on GLP-1s and Midlife Metabolism, triple Board-certified in Obesity Medicine; fellowship-trained in Endocrinology, Diabetes & Metabolism Dr. Rocio Salas-Whalen continues her discussion with Dr. Mary Claire Haver, going deeper into what happens after weight loss including the physical and emotional changes no one prepares you for, and what the future of these medications looks like.

Dr. Salas-Whalen, founder of New York Endocrinology and author of the upcoming book Weightless, tackles the questions women are actually asking: How do I know if I'm getting good care? What about compounding pharmacies? Will I need therapy? And what comes next in obesity medication?

The conversation addresses the psychological shifts that happen when you reach your goal weight for the first time in your life. Dr. Salas-Whalen shares what she's learned from following patients long-term and why the maintenance phase is actually the most important part of treatment.

Dr. Salas-Whalen also addresses the cost and accessibility crisis around Ozempic, Wegovy, and Mounjaro, the environmental impact of single-use injection pens, and why direct-from-manufacturer vials (like Eli Lilly's Zepbound vials) are making treatment more affordable. She shares her standard of care for obesity treatment and explains exactly what questions to ask before starting GLP-1 therapy.

For women experiencing perimenopause and menopause weight gain, this episode provides useful information about what to expect beyond initial weight loss, how to maintain results long-term, and why proper medical supervision with body composition monitoring is essential for protecting muscle mass and metabolic health.

Guest links:

Meet Your Endocrinologist - Dr. Salas-Whalen (NY Endocrinology)Dr. Rocio Salas-Whalen (Instagram)

Books:

“Weightless: A Doctor's Guide to GLP-1 Medications, Sustainable Weight Loss, and the Health You Deserve” by Dr. Rocio Salas-Whalen

“The New Perimenopause,”⁠ by Dr. Mary Claire Haver

⁠"The New Menopause"⁠ by Dr. Mary Claire Haver

For full show notes, please click here.

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