Zipline CEO Keller Cliffton on air-dropping blood to Rwandan hospitals and getting to 50,000 aircraft per year
Cheeky Pint10 Sep 2025

Zipline CEO Keller Cliffton on air-dropping blood to Rwandan hospitals and getting to 50,000 aircraft per year

Keller Cliffton joins John Collison to talk about Zipline’s journey to 115 million miles flown, the lost art of American airplanes, building 50k drones a year in California, getting to 99.9% reliability, and US vs. Chinese manufacturing.


Books referenced:


Timestamps

(00:00) Intro

(00:45) 115 million miles flown

(04:10) Why drone delivery took so long

(07:38) Getting started in Rwanda

(13:31) 51% reduction in maternal mortality

(15:33) Access vs. waste

(21:45) Scaling globally

(24:05) Zipline’s Platform 1

(25:50) The Right Stuff

(27:22) Drone design and safety

(30:12) Getting to 99.9% reliability

(34:39) Multimodal logistics

(38:15) Zipline’s Platform 2

(44:03) US drone regs and the FAA

(48:02) Progress and stagnation in US aviation

(51:30) If Keller ran the FAA

(54:24) 30% WoW growth in Texas

(58:25) Why Texas and not California?

(01:00:28) Building 50k drones in California

(01:06:18) US vs. Chinese manufacturing

(01:11:30) Advice for hardtech founders

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