Our Brains Weren’t Designed for This Kind of Food

Our Brains Weren’t Designed for This Kind of Food

Our society’s dominant narrative is that body size is a product of individual willpower. We are skinny or fat because of the choices we make: the kinds of food we buy, the amounts we eat, the exercise regimens we follow.

Research has never been kind to this thesis. It’s a folk narrative we use to punish people, not an empirical account of why residents of most rich countries are getting heavier over time. But, then, what account does fit the data?

In his 2017 book, “The Hungry Brain,” Stephan Guyenet, a neurobiologist, argues that weight gain is less about willpower than it is the product of an evolutionary mismatch between our brains, our genetics and our environments. Now a new class of weight loss drugs is raising the possibility that we can change our brains to fit this new environment.

Paired with diet and exercise, Ozempic and Wegovy caused anywhere from about a 15 percent to 18 percent loss of body weight over the course of just over a year in people classified as obese or overweight. And they do this in a way that aligns exactly with Guyenet’s research: They don’t make our bodies burn more calories, they make our brains crave less food.

So I asked Guyenet on the show to talk me through his model of weight gain, the research on these new drugs and the strange implications of living with old brains in a new world.

Mentioned:

Relationship between food habituation and reinforcing efficacy of food” by Katelyn A. Carr and Leonard H. Epstein

Dietary obesity in adult rats: Similarities to hypothalamic and human obesity syndromes” by Anthony Sclafani and Deleri Springer

Why Have Americans Become More Obese?” by David M. Cutler, Edward L. Glaeser and

Jesse M. Shapiro

Persistent metabolic adaptation 6 years after “The Biggest Loser” competition” by Erin Fothergill, Juen Guo, Lilian Howard et al.

The future of weight loss” by Stephan Guyenet

Under a White Sky by Elizabeth Kolbert

Book recommendations:

Burn by Herman Pontzer

Salt Sugar Fat by Michael Moss

The Secret of Our Success by Joseph Henrich

Thoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.

You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.

“The Ezra Klein Show” is produced by Emefa Agawu, Annie Galvin, Jeff Geld, Rogé Karma and Kristin Lin. Fact-checking by Michelle Harris and Kate Sinclair. Mixing by Sonia Herrero. Original music by Isaac Jones. Audience strategy by Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Special thanks to Pat McCusker and Kristina Samulewski.

Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

Episoder(472)

Interesting Times: She Exposed Epstein and Shares MAGA’s Anger

Interesting Times: She Exposed Epstein and Shares MAGA’s Anger

My colleague Ross Douthat talks to the journalist who exposed Jeffrey Epstein. This episode of “Interesting Times,” with the Miami Herald investigative journalist Julie K. Brown, came out back in July. But since Epstein has very much stayed in the news, I wanted to share it now. The conversation is such a fascinating and helpful explainer of the whole case, and the questions that remain unanswered — with the woman whose reporting led to Epstein’s re-arrest.  If you haven’t had a chance to check out “Interesting Times” this year, you really should. The team has produced so many great episodes, especially with leading thinkers and activists on the right. You can find them on the NYT Audio app, Apple, Spotify, Amazon Music, YouTube, iHeartRadio or wherever you get your podcasts. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

2 Des 202559min

Best Of: The ‘Quiet Catastrophe’ Brewing in Our Social Lives

Best Of: The ‘Quiet Catastrophe’ Brewing in Our Social Lives

The holidays are an unusually social time, filled with parties and family get-togethers. But for most of the year, we feel isolated and unsatisfied with our social lives. Our society isn’t structured to support connection year-round. So it’s an apt time to re-air this episode — a conversation with the writer Sheila Liming about rediscovering the lost art of hanging out.Liming is an associate professor of professional writing at Champlain College and the author of “Hanging Out: The Radical Power of Killing Time.” In the book, Liming investigates the troubling fact that we’ve grown much less likely to simply spend time together outside our partnerships, workplaces and family units. What would it look like to reconfigure our world to make social connection easier for all of us?I spoke to Liming in April 2023. But I find that this conversation provides a clearer sense of what’s gone wrong in our social lives — and how to make “hanging out” with others more fulfilling.Note: We're still gathering questions for an upcoming "Ask Me Anything" episode we'd like to record. If you have any questions for Ezra, please email ezrakleinshow@nytimes.com using the subject line "AMA."Mentioned:“You’d Be Happier Living Closer to Friends. Why Don’t You?” by Anne Helen Petersen“The Nuclear Family Was a Mistake” by David BrooksFull Surrogacy Now by Sophie LewisRegarding the Pain of Others by Susan SontagLetters from Tove by Tove JanssonBook Recommendations:Black Paper by Teju ColeOn the Inconvenience of Other People by Lauren BerlantThe Hare by Melanie FinnThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” is produced by Annie Galvin, with Jeff Geld, Rogé Karma and Kristin Lin. Fact-checking by Michelle Harris, Mary Marge Locker and Kate Sinclair. Mixing by Jeff Geld. Original music by Isaac Jones. Audience strategy by Shannon Busta. The executive producer of New York Times Opinion Audio is Annie-Rose Strasser. Special thanks to Sonia Herrero and Kristina Samulewski. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

25 Nov 20251h 15min

Fareed Zakaria Thinks Steve Bannon Got One Thing Right

Fareed Zakaria Thinks Steve Bannon Got One Thing Right

On Monday night, in front of a live audience, I talked to Fareed Zakaria about the different political age he believes we’ve entered. Zakaria is the host of “Fareed Zakaria GPS” on CNN and the author of the 2024 book “Age of Revolutions: Progress and Backlash From 1600 to the Present.” To mark the release of the book in paperback, Zakaria invited me to have this conversation at Symphony Space in New York City. We discuss the “revolution” we may be living through, the forces driving it,  and how the Democratic Party can adapt.Mentioned:The Tea Party and the Remaking of Republican Conservatism by Theda Skocpol and Vanessa Williamson"The Time Tax" by Annie Lowrey"Behind Trump and Vance Is This Man’s Movement" by Ezra Klein"The end of progress against extreme poverty?" by Max Roser"What Does the ‘Post-Liberal Right’ Actually Want?" by The Ezra Klein ShowEscape from Freedom by Erich FrommBook Recommendations:A Preface to Morals by Walter LippmannThe Coming Of Post-Industrial Society by Daniel BellThe Lost City by Alan EhrenhaltThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Jack McCordick. Fact-checking by Michelle Harris, with Kate Sinclair and Mary Marge Locker.  Our senior engineer is Jeff Geld. Mixing by Isaac Jones. Our executive producer is Claire Gordon.  The show’s production team also includes Marie Cascione, Annie Galvin, Rollin Hu, Kristin Lin, Emma Kehlbeck, Marina King and Jan Kobal. Original music by Dan Powell and Pat McCusker. Audience strategy by Kristina Samulewski and Shannon Busta. The director of New York Times Opinion Audio is Annie-Rose Strasser. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

21 Nov 20251h 8min

Patti Smith on the One Desire That Lasts Forever

Patti Smith on the One Desire That Lasts Forever

Patti Smith, “the Godmother of Punk,” has lived a wild life and accumulated so much wisdom in the process. In the 1960s and ’70s, Smith was a fixture of the New York City creative scene — hanging out with the likes of Bob Dylan, Janis Joplin, Allen Ginsberg and Robert Mapplethorpe. Merging her own poetry with an ace backing band, she became a global rock star. Then she gave it up, moved to Michigan, raised a family, and remade herself into a best-selling author. Her stunning memoir “Just Kids” won the National Book Award and is one of the books that I’ve kept returning to, again and again.There is clearly something unusual about Smith. People who know her have described her as “shamanistic.” But even for those of us who will never become rock stars, there’s something inspiring — and oddly relatable — in how she thinks about life. So I was excited to have the opportunity to sit down with her and learn more.Smith is out with a new memoir, “Bread of Angels,” and is on tour for the 50th anniversary of her breakthrough album, “Horses.” We talk about that book and that album and so much more: the boundless curiosity that drives her; the books that shaped her; her childhood communion with a snapping turtle; what Andy Warhol was like; what color she thinks the soul is; and a lot more that’s hard even to describe.This episode contains strong language.Mentioned:“Pan’s Labyrinth” by Guillermo del ToroGrimm’s Complete Fairy Tales by Jacob Grimm and Wilhelm GrimmBread of Angels by Patti SmithJust Kids by Patti Smith“The Dark Blot” by Gérard de Nerval“Genie” by Arthur Rimbaud“Guernica” by Pablo Picasso“The Last Supper” by Andy WarholBook Recommendations:The Adventures of Pinocchio by Carlo CollodiFrankenstein by Mary ShelleyThe Poetry of Sylvia Plath Edited by Claire Brennan2666 by Roberto BolañoThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Annie Galvin. Fact-checking by Annika Robbins. Our senior engineer is Jeff Geld, with additional mixing by Isaac Jones. Our executive producer is Claire Gordon. The show’s production team also includes Marie Cascione, Rollin Hu, Kristin Lin, Emma Kehlbeck, Jack McCordick, Michelle Harris, Marina King and Jan Kobal. Original music by Pat McCusker and Carole Sabouraud. Audience strategy by Kristina Samulewski and Shannon Busta. The director of New York Times Opinion Audio is Annie-Rose Strasser. Special thanks to Caryn Rose. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

18 Nov 20251h 17min

Tucker Carlson, Nick Fuentes and the Right’s ‘Groyper’ Problem

Tucker Carlson, Nick Fuentes and the Right’s ‘Groyper’ Problem

Is this the future of MAGA?Tucker Carlson’s interview with the white nationalist influencer Nick Fuentes has caused a firestorm on the right. Carlson and Fuentes’s friendly chat about American Jews — whether they fit into this country or were loyal to Israel above all — was the kind of conversation that for decades would have been unimaginable among mainstream figures in politics. And by crossing that line, Carlson was making a statement — about the power of Fuentes’s movement and the future of MAGA.To help me think through this, I wanted to talk to the political writer John Ganz. He’s studied the roots of antisemitism on the right and has followed the evolution of MAGA closely. He’s behind the newsletter Unpopular Front and the author of “When the Clock Broke: Con Men, Conspiracists, and How America Cracked Up in the Early 1990s.”This episode contains strong language.Mentioned:“Unpopular Front” by John Ganz“Finding Neverland” by John Ganz“Groyperfication” by John GanzBook Recommendations:Taking America Back by David Austin WalshFurious Minds by Laura K. FieldProphets of Deceit by Norbert Guterman & Leo LowenthalThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Jack McCordick. Fact-checking by Ashley Braun. Our senior engineer is Jeff Geld, with additional mixing by Isaac Jones. Our executive producer is Claire Gordon. The show’s production team also includes Marie Cascione, Annie Galvin, Rollin Hu, Kristin Lin, Emma Kehlbeck, Marina King and Jan Kobal. Original music by Pat McCusker. Audience strategy by Kristina Samulewski and Shannon Busta. The director of New York Times Opinion Audio is Annie-Rose Strasser. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

14 Nov 20251h 23min

What Were Democrats Thinking?

What Were Democrats Thinking?

Democrats’ case for the government shutdown was just starting to break through to voters. Why fold now?Thoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find the transcript and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.html This column read was produced by Kristin Lin. Fact-checking by Jack McCordick. Our senior engineer is Jeff Geld, with mixing by Isaac Jones. Our executive producer is Claire Gordon. The show’s production team also includes Marie Cascione, Annie Galvin, Michelle Harris, Rollin Hu, Marina King, Emma Kehlbeck and Jan Kobal. Original music by Aman Sahota and Pat McCusker. Audience strategy by Kristina Samulewski and Shannon Busta. The director of New York Times Opinion Audio is Annie-Rose Strasser.Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

10 Nov 202510min

The Blue Wave Cometh?

The Blue Wave Cometh?

Democrats won big on Tuesday. It looks like the MAGA coalition has started to crack.Ezra is joined by his column editor, Aaron Retica, to discuss the big lessons for Democrats as they eye the midterms next year, and whether an anti-MAGA playbook is coming into focus.This episode contains strong language.NOTE: We're recording an "Ask Me Anything" episode soon. You can send your question to ezrakleinshow@nytimes.com with the subject line "AMA." We'll consider any questions submitted on or before the morning of Monday November 11 at 10am ET.Mentioned:“This Is the Way You Beat Trump — and Trumpism” by Ezra KleinOrdinary Vices by Judith N. ShklarMarc Maron's podcast with Barack Obama“Zohran’s Smile” by Anand GhiridharadasThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find transcripts (posted midday) and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast, and you can find Ezra on Twitter @ezraklein. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.This episode of “The Ezra Klein Show” was produced by Annie Galvin. Fact-checking by Michelle Harris, Kate Sinclair and Marie Cascione. Our senior engineer is Jeff Geld. Mixing by Isaac Jones. Our executive producer is Claire Gordon. The show’s production team also includes Rollin Hu, Kristin Lin, Emma Kehlbeck, Jack McCordick, Marina King and Jan Kobal. Original music by Pat McCusker. Audience strategy by Kristina Samulewski and Shannon Busta. The director of New York Times Opinion Audio is Annie-Rose Strasser. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

7 Nov 202558min

This Is How the Democratic Party Beats Trump

This Is How the Democratic Party Beats Trump

Democrats don’t just need to win more people; they also need to win more places. And that requires a different kind of thinking.Mentioned:"How Liberalism Wins" by Ezra KleinThoughts? Guest suggestions? Email us at ezrakleinshow@nytimes.com.You can find the transcript and more episodes of “The Ezra Klein Show” at nytimes.com/ezra-klein-podcast. Book recommendations from all our guests are listed at https://www.nytimes.com/article/ezra-klein-show-book-recs.htmlThis episode of “The Ezra Klein Show” was produced by Claire Gordon, Marie Cascione and Kristin Lin. Fact-checking by Michelle Harris. Our senior engineer is Jeff Geld. Our executive producer is Claire Gordon. The show’s production team also includes Annie Galvin, Rollin Hu, Emma Kehlbeck, Jack McCordick, Marina King and Jan Kobal. Original music by Pat McCusker. Audience strategy by Kristina Samulewski and Shannon Busta. The director of New York Times Opinion Audio is Annie-Rose Strasser. Special thanks to Isaac Jones. Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.

2 Nov 202537min

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