MD Longevity Lab: Playing the Long Game with Drs. Vikas and Nisha Patel12 Mar

25. Evolutionary Mismatch 101: Ancient Genes, Modern Diseases

🎉 One-Year Anniversary Episode 🎉It's our 25th episode and one-year podcast anniversary, and we're going to the foundation. Why are heart disease, cancer, Alzheimer's, diabetes, obesity, and depression exploding in modern life but virtually absent in hunter-gatherer populations? The answer is evolutionary mismatch — the growing gap between the environment our genes were built for and the one we live in now. This is the "why" behind everything we've covered this past year.

In This Episode:

What evolutionary mismatch is and why 10,000 years of agriculture is nothing compared to 2 million years of hunter-gatherer evolution. How mismatch drives disease through appetite dysregulation, chronic stress, circadian disruption, and social isolation. The Six Horsemen framework — expanding beyond the familiar four to include frailty and depression/mental illness. Why you're not broken, you're mismatched — and why that's actually good news. The practical playbook: movement, real food, sleep, connection, stress management, and purpose. Plus: Vikas announces his upcoming book, Playing the Long Game.

Key Takeaway:

Chronic diseases aren't inevitable aging — they're predictable outputs of ancient biology in a modern environment. And because they're environmental, they're modifiable.📝 Free Substack: mdlongevitylab.substack.com🌐 mdlongevitylab.com📸 @mdlongevitylab🎧 Subscribe, leave a 5-star review, and share this episode with one person who needs to hear it.

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Episoder(31)

31. The Evidence-Based Supplement Guide: Cutting Through the $60 Billion Noise

The supplement industry is a $60 billion business with almost no regulatory oversight. Three out of four American adults take at least one. Almost none of them know what's actually in the bottle.In th...

4 Jun 56min

30. The Delay Game: How Health Insurance Abandoned Your Healthcare & Why The Long Game of Prevention Belongs to You

The American health insurance industry is no longer in the business of paying for your healthcare. It is in the business of delaying it — long enough that someone else has to pay. Usually Medicare. Wh...

21 Mai 49min

29. The Statin You Fear vs. The Peptide You Trust: The Credibility Crisis in American Healthcare

This episode is a follow-up and expansion of Vikas's recent piece in STAT News on the same topic.Mention statins at a dinner party and you'll get muscle pain, brain fog, and Big Pharma conspiracies. M...

7 Mai 49min

28. Can You Out-Run Your Cocktail? Exercise, Alcohol, and the Science of Damage Control

Episode Title: Can You Out-Run Your Cocktail? Exercise, Alcohol, and the Science of Damage ControlCan exercise protect you from the damage alcohol does to your body? Drs. Vikas and Nisha Patel break d...

23 Apr 49min

27. GLP-1 Series, Part 2: Muscle Loss, Weight Regain, and the Protocol That Actually Works

The real conversation about GLP-1 medications doesn't end with the prescription. Part 2 is where we get into the uncomfortable truths — the data on muscle loss, the biology of weight regain, the patie...

9 Apr 1h 2min

26. GLP-1 Series, Part 1: The Biology, the Drugs, and Why the Benefits Go Deeper Than the Scale

📝 Free Substack: mdlongevitylab.substack.com🌐 mdlongevitylab.com📸 @mdlongevitylab🎧 Subscribe, leave a 5-star review, and share this episode with one person who needs to hear it.GLP-1 medications a...

26 Mar 52min

24. Zones 1 & 2 Explained: How to Burn Visceral Fat Without Burning Out

🔔 Stay connected! https://www.mdlongevitylab.com/📲 Instagram: https://www.instagram.com/mdlongevitylab/📰 Substack: https://mdlongevitylab.substack.com/🎙️ Podcast: Available on Apple Podcasts, Spot...

26 Feb 1h 4min