Brain Organoids Unlock New Understanding of Developmental Disorders

Brain Organoids Unlock New Understanding of Developmental Disorders

What the hippocampus tells us about exercise, learning, and memory. How organoids are being used in neurodevelopmental research. And the future of medicine and stem cell therapy. In this episode, Dr. Xinyu Zhao, Distinguished Professor of Neuroscience at the University of Wisconsin–Madison, and investigator at the Waisman Center, joins John Foxe, PhD, director of the Del Monte Institute for Neuroscience at the University of Rochester. Dr. Zhao is internationally recognized for groundbreaking research on the molecular mechanisms that regulate neural stem cells, adult neurogenesis, and brain development, including how disruptions in these processes contribute to neurodevelopmental disorders like autism, fragile X syndrome, and Rett syndrome. Dr. Zhao was a keynote speaker at the 2025 Golisano Intellectual and Developmental Disabilities Institute and Del Monte Institute for Neuroscience Symposium.

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🧠Experts in this Episode:

Xinyu Zhao, PhD: https://neuro.wisc.edu/staff/zhao-xinyu/

John Foxe, PhD: https://www.urmc.rochester.edu/people/112360965-john-j-foxe

🧠Labs Mentioned:

Zhao Lab: https://zhao-lab.com/

Frederick J. and Marion A. Schindler Cognitive Neurophysiology Lab: https://urmc.info/1RG

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Episoder(42)

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Rett Syndrome: Symptoms, Genetics, Science, and Clinical Trials

Rett Syndrome: Symptoms, Genetics, Science, and Clinical Trials

What is Rett syndrome—and how close are we to effective treatments? In this episode of Neuroscience Perspectives, Dr. John Foxe, director of the Del Monte Institute for Neuroscience at University of R...

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What the Developing Brain Could Reveal About Autism

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In this episode of Neuroscience Perspectives, we speak with Dr. Shafali Jeste, an internationally recognized child neurologist whose research has advanced the identification of early biomarkers that p...

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Neurons Don't Work Alone: What Neuroscientists Know About Memory Formation

Neurons Don't Work Alone: What Neuroscientists Know About Memory Formation

🧠How do memories form in the brain? How do individual neurons create memories? In this episode of Neuroscience Perspectives, Ueli Rutishauser, PhD, professor of Neurosurgery, Neurology & Biomedical S...

22 Jan 32min

The Role of Neurons in Our Decisions & Behavior

The Role of Neurons in Our Decisions & Behavior

In this episode of Neuroscience Perspectives, Dr. Anne Churchland, professor of Neurobiology at the David Geffen School of Medicine and the Brain Research Institute at the University of California, Lo...

18 Des 202533min

The Future of Memory: Single Neurons, Consciousness & Cognitive Decline

The Future of Memory: Single Neurons, Consciousness & Cognitive Decline

Join this conversation with the world-renowned neurosurgeon and neuroscientist, Dr. Itzhak Fried. In this episode of Neuroscience Perspectives, Dr. Fried, professor of neurosurgery, psychiatry, and bi...

20 Nov 202539min

What Happens When Science Meets Storytelling? With Best-Selling Author & Neuroscientist Lisa Genova

What Happens When Science Meets Storytelling? With Best-Selling Author & Neuroscientist Lisa Genova

In this episode of Neuroscience Perspectives, host John Foxe, PhD, sits down with neuroscientist and New York Times bestselling author Dr. Lisa Genova — acclaimed for her groundbreaking novel Still Al...

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