MRAs in HFpEF & HFmrEF: A Clinical Debate

MRAs in HFpEF & HFmrEF: A Clinical Debate

Are mineralocorticoid receptor antagonists (MRAs) ready for prime time in HFpEF and HFmrEF?

In this special debate-format episode of the Heart Failure Beat, two leading heart failure pharmacists, Stormi Gale, PharmD, BCCP, FHFSA and Robert L Page II, PharmD, MSPH, FHFSA, go head-to-head on steroidal vs non-steroidal MRAs.

From RALES and TOPCAT to FINEARTS-HF, they unpack the evidence, guideline implications, cost-effectiveness, CKM considerations, and real-world barriers to access. Is finerenone the “new pillar” in HFpEF? Or does spironolactone remain the practical, evidence-based choice? The conversation also explores phenotyping challenges in HF trials and whether combining SGLT2 inhibitors with MRAs can attenuate hyperkalemia risk.

If you care about precision medicine, cardiorenal overlap, or optimizing GDMT in complex patients, this debate is for you.

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Episoder(52)

HFmrEF: Finding a Compass in the Heart Failure "No Man's Land"

HFmrEF: Finding a Compass in the Heart Failure "No Man's Land"

Heart failure with mildly reduced ejection fraction (HFmrEF) affects up to 25% of patients with heart failure, yet many clinicians remain uncertain about how best to diagnose and treat it. In this epi...

25 Jun 27min

A New Dawn in Inflammatory & Infiltrative Cardiomyopathies

A New Dawn in Inflammatory & Infiltrative Cardiomyopathies

The May (2026) issue of the Journal of Cardiac Failure shines a spotlight on infiltrative and inflammatory cardiomyopathies, including amyloidosis, sarcoidosis, and myocarditis, and the rapidly evolvi...

21 Mai 32min

Integrating Technology for Smarter Heart Failure Care

Integrating Technology for Smarter Heart Failure Care

Heart failure care is entering a new era - one defined not by singular devices, but by integrated systems of technology working together. In this episode, Laura Peters, DNP, joins The Heart Failure Be...

19 Feb 28min

Rethinking Sodium Restriction in Heart Failure: What the Evidence (Doesn’t) Show

Rethinking Sodium Restriction in Heart Failure: What the Evidence (Doesn’t) Show

For decades, sodium restriction has been treated as a cornerstone of heart failure self-care—despite limited trial-quality evidence. In this episode of Heart Failure Beat, Dr. Tariq Ahmad (Yale School...

22 Jan 25min

HFSA Presidential Voices: Leading the Modern Era of Heart Failure

HFSA Presidential Voices: Leading the Modern Era of Heart Failure

Priya Umapathi, MD speaks with six HFSA past presidents live from ASM 2025. Nancy M. Albert, PhD, CCNS, CCRN, NE-BC, Biykem Bozkurt, MD, PhD, Jim Fang, MD, FHFSA, Mark H. Drazner, MD MSc, Michael Felk...

18 Des 202525min

Revisiting the Fundamentals: Hemodynamics at the Heart of Heart Failure Care

Revisiting the Fundamentals: Hemodynamics at the Heart of Heart Failure Care

Guest editors Drs. Mak, Burkhoff, and Belkin join Heart Failure Beat to unpack the Journal of Cardiac Failure Hemodynamics Focus Issue. They discuss how renewed attention to pressure-volume loops, ECM...

15 Nov 202526min

Behind the Pages of the New Journal, JCF-Intersections

Behind the Pages of the New Journal, JCF-Intersections

Meet the editorial team behind JCF-Intersections, HFSA’s and the JCF Family of Journal’s new open-access journal. Drs. Jason Katz and Nosheen Reza share their vision for a journal that sits at the cro...

20 Sep 202528min

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