Everyone Can Live Longer and Healthier, Here’s the Playbook to Make it Affordable! - Dr. Mehmood Khan

What if we could add not just years to life but life to years?

Join me at the Global Longevity Summit this October. Use code BEYONDTOMORROW for 10% off your ticket: https://www.a4m.com/global-longevity-summit-2025.html

In this episode, I’m sitting down with Dr. Mehmood Khan, CEO of Hevolution Foundation, a global initiative pledging up to $1 billion per year to advance longevity science. Dr. Khan shares how his team is tackling one of humanity’s greatest challenges: helping everyone stay healthy for as long as possible.

From the economics of an aging world to cutting-edge therapies like senolytics, epigenome modulation, and AI-driven discovery, Dr. Khan explains why healthspan - not just lifespan is the real moonshot. He reveals how Hevolution funds hundreds of research programs worldwide, why the Gulf region faces unique aging patterns, and how breakthroughs in the next decade could transform medicine, society, and the global economy.

Whether you’re a biotech investor, health enthusiast, or simply curious about living better for longer, this conversation delivers science, strategy, and a hopeful vision of the future.

📌 What You’ll Learn in This Episode

• Why healthspan matters more than raw lifespan

• The $1 billion annual commitment behind Hevolution Foundation

• How aging challenges economies, families, and global stability

• Genetic vs. lifestyle factors in accelerated aging

• Promising therapeutics: senolytics, mTOR modulation, epigenome reprogramming

• How AI accelerates longevity research

• The TAME trial and metformin’s potential

• Scaling breakthroughs so everyone benefits

• The next decade of longevity science - what’s realistic and what’s hype
  

⏱️ Timestamps

00:00 – Opening & mission to expand healthy lifespan

01:04 – Global Longevity Summit & Hevolution’s vision

02:24 – Why “healthspan” is the true goal

05:09 – Dr. Khan’s early career and medical insights

07:17 – Building a foundation to invest $1 billion annually

09:55 – Saudi Arabia’s long-term approach to longevity

12:49 – Why some populations age faster

16:27 – Economic and social costs of an aging world

22:42 – How to spark a global movement for healthspan

28:21 – Balancing visionary goals with practical milestones 32:59 – Funding breakthroughs - senolytics, TAME trial, more 38:32 – Targeting senescent cells in real-world therapies

44:01 – Making advanced treatments affordable for all

47:33 – The most promising areas: mTOR, epigenome, gene therapy

52:07 – Predictions for 2030 and realistic healthspan gains 55:28 – The role of AI in longevity research

1:00:42 – Why Dr. Khan is optimistic about the future

1:03:09 – Closing thoughts and next-episode preview