Fitt Insider5 Aug 2025

300. Leo Grady, PhD, Founder and CEO of Jona

Today, I'm joined by Leo Grady, PhD, founder and CEO of Jona.

Jona uses metagenomic sequencing and machine learning to deliver personalized metabolic health insights, predicting how factors like diet and lifestyle affect the gut.

In this episode, we discuss upgrading microbiome testing with AI technology.

We also cover:

Why gut tests could outpace blood tests
Building AI to read medical literature at scale
Using digital twins to predict health outcomes

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Jona Health's Website: https://jona.health/

Jona Journal (Newsletter & Blog): https://jona.health/blogs/journal

Instagram: https://www.instagram.com/jonahealth/

X (Twitter): https://x.com/jona_health

Facebook: https://www.facebook.com/JonaHealth/

LinkedIn: https://www.linkedin.com/company/jona-health/

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Chapters:

(00:00) Introduction

(00:20) Leo's Background

(02:15) Why the Microbiome is the Perfect AI Application

(06:10) Building AI to Read Medical Literature at Scale

(09:55) From Testing to Interventions

(13:30) Avoiding Supplement Sales for Credibility

(15:25) Direct Consumer and Clinical Partnerships

(17:25) Digital Twin Technology in Healthcare

(21:15) Three Customer Types and Testing Frequency

(23:00) Microbiome vs Blood Testing

(27:25) Education and Category Building Challenges

(29:25) Technology Applications Beyond Microbiome

(32:10) Health Tracking Integrations

(37:00) Regulatory Considerations and Future Diagnostics

(37:45) 2025 Roadmap and New Features

(39:15) Conclusion

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