From Princeton to the Nobel Prizes — How FFP Started + 2025 Nobel Recap (EP. 12)

From Princeton to the Nobel Prizes — How FFP Started + 2025 Nobel Recap (EP. 12)

After a packed week of Nobel Prize coverage, Lester and Krishna look back on how From First Principles began and why they built it as an “ESPN for Science.” They revisit 2025’s Medicine, Physics and Chemistry winners and discuss why fundamental research and immigration policy are core to America’s scientific edge.


Quick note: this week’s episode is in vertical format because of a technical hiccup during recording — back to widescreen next week!


Summary

  • Origin Story — Two Princeton friends from different continents unite around a shared love of science and storytelling.
  • The Mission — Creating an “ESPN for Science” that celebrates research and the people behind it.
  • Nobel Follow-ups — Medicine (Tregs and non-immune roles), Physics (macroscopic quantum tunneling and quantum supremacy), Chemistry (MOFs and industrial scaling).
  • Funding + Immigration — Why public research grants and curating global talent are vital to scientific leadership.

Show Notes

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Episoder(63)

Nobel Prize in Chemistry 2026 Explained: Mirror Molecules (EP 63)

Nobel Prize in Chemistry 2026 Explained: Mirror Molecules (EP 63)

Why does life favor one molecular mirror image? The 2026 Nobel Prize in Chemistry honors Henri B. Kagan and Kenso Soai for nonlinear effects and autocatalysis in asymmetric organic synthesis.Lester Na...

7 Okt 1h 20min

Nobel Prize in Physics 2026 Explained: IceCube & Neutrinos (EP 62)

Nobel Prize in Physics 2026 Explained: IceCube & Neutrinos (EP 62)

Why build a telescope inside a billion tons of Antarctic ice? The 2026 Nobel Prize in Physics recognizes Francis Halzen's work on IceCube and the discovery of high-energy neutrinos from the cosmos.In ...

6 Okt 1h 2min

Nobel Prize in Medicine 2026 Explained: Optogenetics (EP 61)

Nobel Prize in Medicine 2026 Explained: Optogenetics (EP 61)

How do you prove what a brain cell actually does? The 2026 Nobel Prize in Medicine celebrates a remarkable answer: give cells a light-sensitive protein, then switch their activity on or off with light...

5 Okt 1h 11min

2026 Nobel Prize Predictions: Medicine, Physics & Chemistry (EP 60)

2026 Nobel Prize Predictions: Medicine, Physics & Chemistry (EP 60)

Who could win the 2026 Nobel Prizes? From the science behind Ozempic to quantum interference and droplets inside living cells, Lester Nare and Krishna Choudhary make their picks for Medicine, Physics ...

3 Okt 40min

Golden Goose Awards 2026: The Science Behind the Winners (Part 1) (EP 59)

Golden Goose Awards 2026: The Science Behind the Winners (Part 1) (EP 59)

What connects a noise complaint, holiday lights seen from space, and the physics of a coffee stain? Three unexpected paths from basic research to discoveries with real-world impact.Krishna Choudhary a...

29 Sep 2h 7min

What OpenAI Actually Did to Navier-Stokes (EP 58)

What OpenAI Actually Did to Navier-Stokes (EP 58)

What does it mean to solve an equation that describes almost every fluid around us, from the air over a wing to the water swirling down a drain?In Episode 58 of From First Principles, Lester Nare and ...

24 Sep 4h 9min

What’s Next in Science? Nobel Prizes, Space Missions & More (EP 57)

What’s Next in Science? Nobel Prizes, Space Missions & More (EP 57)

What science should you be watching this fall? From Nobel Prize season to NASA’s Roman Space Telescope, Mars’ moons and Mercury, Lester Nare and Krishna Choudhary take a relaxed tour of the discoverie...

14 Sep 1h 3min

The Yak Mutation That Could Help Repair the Brain (EP 56)

The Yak Mutation That Could Help Repair the Brain (EP 56)

What can a yak living thousands of meters above sea level teach us about repairing the human brain?In Episode 56 of From First Principles, Lester Nare and Krishna Choudhary break down a new Neuron pap...

7 Sep 1h 35min

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