Peptide of the Week: Autoimmune, Gut Health & GLP-1s – With Paul Bakhtiar

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas are joined by returning fan favorite Paul Bakhtiar peptide Jedi and clinical consultant for a deep dive into autoimmune disorders, gut health, GLP-1 optimization, and protocols working in real clinical settings.
Chapters:00:00 – Intro & Mixing Peptides Debate04:44 – Peptides for Recovery & Inflammation09:31 – Autoimmune Disorders Explained15:30 – Thymalin, TA1 & Immune Function18:38 – LL-37, VIP & Pathogen Response23:13 – Crohn’s, Hashimoto’s & Gut Health27:06 – BPC-157, Angiogenesis & Healing32:19 – Surgery Recovery & Peptide Protocols33:01 – Vitiligo, Psoriasis & Skin Healing35:35 – Folliculitis, Leaky Gut & Carnivore41:10 – Toxins, Sauna & Detoxification46:04 – GLP-1s, Inflammation & Neuroprotection52:04 – Estrogen, TRT & Bloodwork Optimization56:44 – SS-31, MOTS-C & Neuropathy Recovery
We cover:🧬 What's happening in autoimmune disorders– Body attacks itself — thyroid in Hashimoto's, gut in Crohn's, skin in psoriasis– 80% of diagnosed autoimmune disorders occur in women– Root cause is almost always the gut — fix the gut, everything follows– Antibiotics, processed food, seed oils, stress, and poor sleep are the biggest culprits
🛡️ Master Autoimmune Protocol (Psoriasis, Lupus, Lyme, MS)– Thymalin: re-educates immune system — the marathon (5–10mg, 10 days straight)– Thymosin Alpha-1 (TA-1): quick sprint to boost T cells (1.5mg, 3x/week, 6–8 weeks)– Run both together– LL-37: penetrates biofilm, dumps pathogens — 125mcg for 50 days– ⚠️ Don't start LL-37 too early — triggers Herxheimer reaction– VIP: cleans up after LL-37 — start 100mcg 3x/week, build to 200mcg– Always anchor with KPV + BPC-157
🦠 Crohn's & Colitis Protocol– KPV + BPC-157 orally first — straight to the source– Add Thymalin + TA-1 simultaneously– Bring in LL-37 if not responding, follow with VIP, then MoTC– Support stack: Glutathione + NAC + L-Glutamine
🦋 Hashimoto's Protocol– Same immune foundation: TA-1, Thymalin, KPV, BPC-157 + MoTC– Once markers trend down — add GH peptides (Tesmorelin or CJC + Ipamorelin) for muscle wasting– Monitor insulin, thyroid levels, and autoimmune markers before adding GH axis
🧫 SS-31 vs MoTC– SS-31 first: repairs the engine– MoTC second: press the gas– SS-31 also powerful for kidney repair, neuropathy, and heart health
🔬 ARA-290– Derivative of EPO — no blood doping effects– Exceptional for neuropathy and nerve regeneration– Pairs well with SS-31
💉 GLP-1 Optimization– Reta: Paul hasn't seen anyone need to exceed 8mg– Plateaued on tirzepatide or sema? Titrate down while titrating Reta up– Clinical tip: GLP-1 on Monday → add small CAG dose by Thursday to quiet food noise– GLP-1s are neuroprotective — control glucose to the brain, help prevent Type 3 Diabetes (Alzheimer's, Parkinson's, dementia)
💡 Real Talk– No peptide protocol doesn't benefit from BPC-157– Sauna 3x/week at 150–160°F for 20 min is one of the best detox tools available– The compounds work. The lifestyle makes them extraordinary.
🧪 This isn't theory this is real-world experience working with hundreds of people and seeing what actually works.
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