BPC-157: The Body's Own Repair Peptide | Age-Less Top 20 Peptides

BPC-157: The Body's Own Repair Peptide | Age-Less Top 20 Peptides

This is the first episode in a new series: the Top 20 Peptides. Over twenty episodes, Dr. Ethan Hausman-Marquis examines the most researched compounds in longevity and regenerative medicine — the real biochemistry, the honest evidence base, and the regulatory context behind each one. No hype, no discount codes. Just the science.

We start with BPC-157. Derived from a naturally occurring sequence in human gastric juice and studied for over thirty years, it's the peptide that put this whole field on the map — and one of the most misunderstood molecules in it. This episode covers how it was discovered, what its proposed mechanisms actually are at the molecular level, what the preclinical research genuinely shows across five areas of investigation, and why a 2025 systematic review of 544 published articles found exactly one human clinical study meeting inclusion criteria.

The evidence base, the open safety questions, the FDA compounding restriction, the WADA prohibition — all of it, examined honestly.

If you're new to peptide science, this series is the foundation. If you're already in the space, this is the rigorous re-examination it deserves.

The Age-Less Top 20 Peptides series. Episode 1 of 20.

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Episoder(46)

Age-less by Design: The Centenarian Genes That Rewrite How We Grow Old

Age-less by Design: The Centenarian Genes That Rewrite How We Grow Old

What separates someone managing a pharmacy's worth of medications at seventy-five from someone who's just getting started on the road to a hundred and two? In this episode, we crack open the biologica...

8 Aug 21min

The Age-less Night: How Your Pineal Gland Rewrites Your Genes While You Sleep

The Age-less Night: How Your Pineal Gland Rewrites Your Genes While You Sleep

Most people treat sleep as simple recovery, but this episode reframes it as the nightly window in which a gland smaller than a pea helps decide how fast you age. That gland is the pineal gland, buried...

3 Aug 20min

The Age-Less Off-Ramp: What Happens When You Stop GLP-1s

The Age-Less Off-Ramp: What Happens When You Stop GLP-1s

The GLP-1 receptor agonists are the most effective weight loss agents ever brought to market, and their efficacy is entirely contingent on continued administration. Three randomized withdrawal studies...

26 Jul 30min

Age-less or Overhyped? The Sixty-Year Cerebrolysin Puzzle |  The Age-Less Top 20 Peptides

Age-less or Overhyped? The Sixty-Year Cerebrolysin Puzzle | The Age-Less Top 20 Peptides

Episode summaryCerebrolysin is a peptide preparation with a strange résumé: developed in Austria more than sixty years ago, approved in nearly fifty countries for stroke, traumatic brain injury, and d...

17 Jul 25min

Age-less by Design: Inside the Cell's Peptide Factory

Age-less by Design: Inside the Cell's Peptide Factory

Episode summaryRight now, inside every cell in your body, trillions of microscopic factories are assembling molecules called peptides — the short chains of amino acids your body uses to talk to itself...

14 Jul 22min

Age-Less LL-37: The Antibiotic in Your Blood | The Age-Less Top 20 Peptides

Age-Less LL-37: The Antibiotic in Your Blood | The Age-Less Top 20 Peptides

LL-37 is the odd one out in the Age-Less peptide series. Where Humanin and MOTS-c were mitochondrial longevity signals, LL-37 is the human cathelicidin — your body's own broad-spectrum antibiotic, a s...

13 Jul 32min

Age-Less Protection: The Real Science of Humanin | The Age-Less Top 20 Peptides

Age-Less Protection: The Real Science of Humanin | The Age-Less Top 20 Peptides

In this episode of The Science of Age-less Living, Dr. Ethan Hausman-Marquis unpacks Humanin — a molecule with one of the most remarkable origin stories in longevity science. Discovered in 2001 in the...

7 Jul 23min

Age-Less Energy: The Real Science of SS-31 | Age-Less Top 20 Peptides

Age-Less Energy: The Real Science of SS-31 | Age-Less Top 20 Peptides

SS-31 — also known as elamipretide — occupies a category no other compound in this series can claim: it is the first mitochondria-targeted therapy ever to receive FDA approval. In this episode, Dr. Et...

30 Jun 22min

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