234 | Tobias Warnecke on Cellular Structure and Evolution

234 | Tobias Warnecke on Cellular Structure and Evolution

Eukaryotic cells manage to pull off a number of remarkable feats. One is packing quite a long DNA molecule, with potentially billions of base pairs, into a tiny central nucleus. A key role is played by histones, proteins that provide scaffolding for DNA to wrap around. Histones also appear in archaea (one of the other domains of life), but until recently there wasn't evidence for them in bacteria (the final of the three domains). Todays guest, Tobias Warnecke, is an author on a recent paper that claims to provide such evidence. We discuss this new result, as well as background questions of how cells evolved and what their current structure can teach us about their histories.

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Tobias Warnecke received his Ph.D. in biology from the University of Bath. He is currently a Programme Leader and MRC Investigator at the London Institute of Medical Sciences. He is a co-author on A. Hochner et al. (2023), "Histone-Organized Chromatin in Bacteria."


Episoder(418)

287 | Jean-Paul Faguet on Institutions and the Legacy of History

287 | Jean-Paul Faguet on Institutions and the Legacy of History

One common feature of complex systems is sensitive dependence on initial conditions: a small change in how systems begin evolving can lead to large differences in their later behavior. In the social s...

26 Aug 20241h 32min

286 | Blaise Agüera y Arcas on the Emergence of Replication and Computation

286 | Blaise Agüera y Arcas on the Emergence of Replication and Computation

Understanding how life began on Earth involves questions of chemistry, geology, planetary science, physics, and more. But the question of how random processes lead to organized, self-replicating, info...

19 Aug 20241h 20min

285 | Nate Silver on Prediction, Risk, and Rationality

285 | Nate Silver on Prediction, Risk, and Rationality

Being rational necessarily involves engagement with probability. Given two possible courses of action, it can be rational to prefer the one that could possibly result in a worse outcome, if there's al...

12 Aug 20241h 11min

AMA | August 2024

AMA | August 2024

Welcome to the August 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patr...

5 Aug 20243h 37min

284 | Doris Tsao on How the Brain Turns Vision Into the World

284 | Doris Tsao on How the Brain Turns Vision Into the World

The human brain does a pretty amazing job of taking in a huge amount of data from multiple sensory modalities -- vision, hearing, smell, etc. -- and constructing a coherent picture of the world, const...

29 Jul 20241h 2min

283 | Daron Acemoglu on Technology, Inequality, and Power

283 | Daron Acemoglu on Technology, Inequality, and Power

Change is scary. But sometimes it can all work out for the best. There's no guarantee of that, however, even when the change in question involves the introduction of a powerful new technology. Today's...

22 Jul 20241h 17min

282 | Joel David Hamkins on Puzzles of Reality and Infinity

282 | Joel David Hamkins on Puzzles of Reality and Infinity

The philosophy of mathematics would be so much easier if it weren't for infinity. The concept seems natural, but taking it seriously opens the door to counterintuitive results. As mathematician and ph...

15 Jul 20241h 18min

Ask Me Anything | July 2024

Ask Me Anything | July 2024

Welcome to the July 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreo...

8 Jul 20243h 21min

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