#163 - Understanding Chronic Spontaneous Urticaria: Hives Demystified

#163 - Understanding Chronic Spontaneous Urticaria: Hives Demystified

Join Kortney and Dr. Payel Gupta as they unpack chronic spontaneous urticaria. Together, they define what hives actually are, explain how CSU is different from an allergic reaction and other types of hives, and walk through what is happening under your skin to cause all that itching.

This episode was originally published June 6, 2024. We re-released it on June 25, 2026 with a new intro as the perfect foundation before our episode on the new chronic urticaria guidelines.

Do you get hives and have no idea why? Then this episode is for you.

What we cover in this episode about chronic hives:
  • What hives really are. Urticaria is the medical word for hives, and the two signs are that it itches and it comes and goes.
  • CSU versus other hives. How CSU differs from inducible hives (CINDU) and from an allergic reaction.
  • Histamine and the itch. Why histamine drives the swelling and itch, and why scratching feels so good.
  • What makes hives flare. CSU has no true trigger, but stress and other culprits can set off your mast cells.
The Itch Podcast Hives Episodes

Explore our full catalog of hives episodes

Diagnosis and the basics

Treatment

Living with chronic hives

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This podcast is made in partnership with Allergy and Asthma Network.

We thank Novartis for originally sponsoring this episode.

This podcast is for informational purposes only and does not substitute professional medical advice. Any mention of brands is also informational and not an endorsement. Always consult with your healthcare provider for any medical questions or concerns.

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Episoder(172)

#170 - When Asthma Peak Week Hits Adults

#170 - When Asthma Peak Week Hits Adults

Most asthma peak week coverage focuses on kids heading back to school. But adults with asthma are just as much at risk, and often don't realize it until they're already in trouble.  Kortney and Dr. Pa...

13 Aug 29min

#169 - What a School Nurse Wants Parents to Know About Asthma Peak Week

#169 - What a School Nurse Wants Parents to Know About Asthma Peak Week

Every September, doctors see a jump in asthma attacks and ER visits. It's called Asthma Peak Week, and it usually hits the third week of September, right when families are settling into their school r...

6 Aug 41min

#168 - Wildfire Smoke and Your Lungs, What You Need to Know

#168 - Wildfire Smoke and Your Lungs, What You Need to Know

Wildfire smoke used to feel like someone else's problem. Now it can show up on air quality alerts hundreds of miles from any actual fire, and for anyone with asthma, that hazy sky can mean real troubl...

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#167 - How Is Chronic Rhinosinusitis Without Nasal Polyps Diagnosed and Treated?

#167 - How Is Chronic Rhinosinusitis Without Nasal Polyps Diagnosed and Treated?

Chronic rhinosinusitis without nasal polyps (CRSsNP) is the type that makes up most chronic sinusitis cases. It's often mistaken for allergies, a lingering cold, or migraines, which can delay a proper...

24 Jul 28min

#166 - How Pregnancy and Your Baby's Gut Microbiome Play a Role in Food Allergy Prevention

#166 - How Pregnancy and Your Baby's Gut Microbiome Play a Role in Food Allergy Prevention

Food allergy prevention is something most families think about once a baby starts eating. But the gut microbiome begins developing before birth, and what happens during pregnancy matters for the devel...

16 Jul 21min

#165: Gut Microbiome's Role in Food Allergies

#165: Gut Microbiome's Role in Food Allergies

You have probably heard the word "microbiome", but what does it actually mean for someone living with a food allergy? Dr. Carina Venter, a registered dietitian, joins us to break down the gut’s role i...

9 Jul 35min

#164 - New Chronic Hives Guidelines: A Look at What's Changing

#164 - New Chronic Hives Guidelines: A Look at What's Changing

In this journal club episode, we break down the draft of the Chronic Urticaria Guidelines: 2026 AAAAI/ACAAI Joint Task Force (JTF) on Practice Parameters GRADE- and Institute of Medicine-based recomme...

2 Jul 32min

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