#211  Breaking Down MASLD vs. MASH and the MAESTRO-NASH & ESSENCE Trials: Beyond Journal Club Segment

#211 Breaking Down MASLD vs. MASH and the MAESTRO-NASH & ESSENCE Trials: Beyond Journal Club Segment

MASLD affects nearly one in three adults worldwide, yet many patients remain undiagnosed until advanced fibrosis or cirrhosis develops. So, which patients should clinicians actually be screening? When is a FIB-4 enough, and when should we move to elastography or hepatology referral? And are we finally entering an era where we can meaningfully treat MASH?

In this Beyond Journal Club episode, we unpack the evolving language of steatotic liver disease and take a close look at two major trials: MAESTRO-NASH studying resmetirom, the first FDA-approved liver-directed therapy for MASH, and ESSENCE, evaluating semaglutide in biopsy-confirmed disease.

Along the way, we explore what these biopsy-based histologic endpoints really mean, why placebo responses were surprisingly high, and whether improvements in steatohepatitis and fibrosis will ultimately translate into better clinical outcomes for patients.

This episode is for clinicians trying to understand where the field is headed, which patients deserve closer attention, and how metabolic liver disease is increasingly becoming part of everyday primary care and hospital medicine.


🔹Sponsor: Oakstone CME

Use the code "CORE325" for 25% off: https://www.coreimpodcast.com/MKSAP


🔹Transcript and Shownotes:

01:57 | Understanding MASLD as a Systemic Disease

05:45 | MASLD vs MASH vs Met-ALD: Spectrum Steatotic Liver Disease

08:55 | How to Screen for Fibrosis (FIB-4 & FibroScan)

16:15 | Lifestyle Treatment & Weight Loss Targets

19:00 | ESSENCE Trial: Semaglutide for MASH

21:58 | MAESTRO-NASH Trial: Resmetirom

27:27 | Future Treatments for MASH

30:51 | Key Takeaways for Clinicians


Tags: CoreIM, Internal Medicine, Medical Education, Hepatology, Fatty Liver Disease, Metabolic Dysfunction Associated Steatohepatitis, Nonalcoholic Fatty Liver Disease, Liver Fibrosis



Find the best disability insurance for you: https://www.patternlife.com/disability-insurance?campid=497840

Our Sponsors:
* Check out CovePure and use my code CovePure.com/coreim for a great deal: https://covepure.com
* Check out ElevenReader and use my code PODCAST for a great deal: https://elevenreader.io
* Check out FIGS: https://wearfigs.com


Advertising Inquiries: https://redcircle.com/brands

Privacy & Opt-Out: https://redcircle.com/privacy

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(222)

#214 Hyponatremia Management: A Core IM Classic

#214 Hyponatremia Management: A Core IM Classic

Throwback: Should you really fluid-restrict every patient with SIADH? When can IV fluids make hyponatremia better or worse? Are salt tabs actually doing enough? And what can urine studies tell you bef...

12 Aug 44min

#213 Hypertension First-Line Medications Troubleshooting | Bread & Butter Series

#213 Hypertension First-Line Medications Troubleshooting | Bread & Butter Series

Why can lower-dose combinations be more effective and better tolerated than maximizing one medication? How to troubleshoot common challenges such as amlodipine edema, gout, electrolyte abnormalities, ...

28 Jul 32min

#212 Top 10 Highlights of the New Lipid Guidelines

#212 Top 10 Highlights of the New Lipid Guidelines

Learn from primary care docs what has been practiced and changed from the 2026 ACC/AHA Lipid Guidelines! Learn how the new CPR framework (Calculate, Personalize, Reclassify) and PREVENT risk calculato...

15 Jul 23min

#210 HTN in Dialysis: 5 Pearls Segment

#210 HTN in Dialysis: 5 Pearls Segment

What blood pressure should we target in patients on hemodialysis? Why volume control remains the foundation of treatment? How blood pressure targets differ from the general population. Learn practica...

17 Jun 25min

#209 Dialysis and Fluid Management: 5 Pearls Segment

#209 Dialysis and Fluid Management: 5 Pearls Segment

Why is fluid management the most important part of dialysis care? This episode explores the fundamentals of hemodialysis, why ESKD patients have unique physiology, and how volume overload, not just hy...

10 Jun 31min

#208 AI vs. Human with Post-Op AFib: Bread & Butter Series

#208 AI vs. Human with Post-Op AFib: Bread & Butter Series

Can AI manage post-op atrial fibrillation or does medicine still require human judgment? Using post-op AFib as a case study, we explore where algorithms help, where evidence falls short, and why clini...

27 Mai 29min

#207 Is There a Doctor on Board? In-Flight Emergencies

#207 Is There a Doctor on Board? In-Flight Emergencies

We start with a gripping story of seizures and use it as a jumping-off point to unpack practical pearls for in-flight emergencies. Along the way: what’s actually in the emergency medical kit, when pla...

18 Mai 27min

Populært innen Fakta

fastlegen
dine-penger-pengeradet
relasjonspodden-med-dora-thorhallsdottir-kjersti-idem
foreldreradet
treningspodden
jakt-og-fiskepodden
rss-kunsten-a-leve
rss-strid-de-norske-borgerkrigene
mikkels-paskenotter
hverdagspsyken
sinnsyn
fryktlos
gravid-uke-for-uke
rss-var-forste-kaffe
rss-sarbar-med-lotte-erik
laringsmiljo-i-skole-og-barnehage-uis-podkast
rss-orjasater
rss-impressions-2
kvallm
lrerrommet