439: Coembedding Sequence and Structure: CLSS Maps the Protein Universe
Longo LM et al., PNAS - This episode summarizes a PNAS study introducing CLSS, a contrastive two-tower protein language model that coembeds domain sequences, structures, and subsequences into a shared...
11 Aug 23min
438: Mapping AIRE: a proactive atlas of 9,790 missense variants
Axakova A et al., The American Journal of Human Genetics - Axakova et al. generated a variant effect map for AIRE using an insulin‑promoter GFP reporter in HEK293 cells to measure the functional impac...
10 Aug 24min
437: Cell villages and Dirichlet modeling map human cell fitness genetics
Hanson C et al., The American Journal of Human Genetics - Hanson et al. combine pooled multi-donor human neural progenitor cell "villages" with Townlet, a hierarchical Dirichlet regression model, to e...
9 Aug 28min
436: KIAP4 and the ARND family: building the Leishmania adhesion plaque
Owino BO et al., PNAS - Using TurboID proximity proteomics and microscopy, researchers identify KIAP4 as the canonical member of a conserved Adhesion Related NTPase-like Domain (ARND) family that loca...
8 Aug 24min
435: E. coli TGT binds two tRNAs — cryo-EM reveals dual engagement
Ember M et al., PNAS - This episode examines a cryo-EM study of Escherichia coli tRNA-guanine transglycosylase (TGT) that solves the enzyme structure and its covalent intermediate with tRNATyr. Unexpe...
7 Aug 19min
434: High‑coverage genomes recast Japan's prehistoric demography
Ishiya K et al., PNAS - This episode examines a PNAS study that reports two high-coverage ancient human genomes from mainland Japan (an Initial Jomon >67× and a Middle Yayoi >46×). The genomes enable ...
6 Aug 27min
433: Lactate, HSP90α and the Mitochondrial Switch
Wu G et al., Proceedings of the National Academy of Sciences - This episode examines a PNAS study that identifies site-specific lactylation of HSP90α as a metabolic signal linking glycolysis to mitoch...
23 Jul 23min
432: Echovirus 18: Capsid opening releases the genome
Mukhamedova L et al., Proceedings of the National Academy of Sciences - Using cryo-electron tomography and single-particle cryo-EM of infected Cos-7 cells, the authors show that echovirus 18 (E18) rel...
23 Jul 18min
