Peptide of the Week: HRT, Peptides & Longevity With Dr. Ksenia

Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.
Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas sit down virtually with Dr. Ksenia, known as Dr. K, a functional medicine doctor based in Miami who specializes in hormone replacement therapy, peptides, and weight loss. This one is packed with real clinical insight, especially for the ladies.
Chapters:00:00 – Intro & Welcoming Dr. K01:34 – Her Specialties: HRT, Peptides & Weight Loss02:34 – Why Hormones Are Crashing in Young Men05:57 – Why Doctors Skip Free Testosterone Testing08:38 – Sleep, Food & Exercise: The Real Fix09:48 – Women's Hormone Symptoms & Menopause Myths14:07 – Finding Your Testosterone "Sweet Spot"19:00 – Cream vs. Injection & What "Normal" Really Means25:30 – Retatrutide vs. Tirzepatide for Inflammation27:21 – Peptides for Athletes & Why BPC Is Banned31:09 – Overhyped Peptides: MOTS-c, SS-31 & IGF-1 LR339:41 – The Ideal Longevity Stack & Real Healing Stories49:42 – Muscle as the Foundation of Healthy Aging54:53 – Fasting, Gut Health & Psychedelics1:04:40 – Fertility Q&A, Dr. K's Personal Stack & Outro
We cover:🧬 Why hormones are crashing in young people– Post-COVID, many men saw testosterone drop significantly, viral illness and vaccines both suspected but no confirmed research yet– Athletes with concussion histories frequently present with low testosterone due to trauma-induced endocrine dysfunction– Excess body fat aromatizes testosterone into estrogen, tanking levels even in young men– Free testosterone is the most important marker, not total, and most insurance doctors never run it– A 12-minute appointment cannot solve a hormone problem, personalized medicine is the only answer
🦋 Women and hormones, the orchestra– Women are not one hormone, they are estrogen, progesterone, testosterone, DHEA, and cortisol all working together– Low estrogen symptoms: hot flashes, night sweats, mood swings– Low progesterone symptoms: inability to stay asleep, anxiety, restlessness– Low testosterone symptoms: zero libido, no motivation, no desire to train– SSRIs are being prescribed for menopausal symptoms instead of hormones, which kills libido and solves nothing– Menopause raises cholesterol because the liver keeps making it to synthesize hormones that are no longer being produced. Giving statins instead of hormones is the wrong answer– Dr. K injects herself with 2 to 3mg of testosterone twice weekly and felt dramatically better within three weeks
💉 Testosterone for women– Injectable testosterone at 10 to 15mg is well within normal female range and will not cause masculinization– Creams work but require a higher concentration to hit therapeutic dose– Compounded injectable estrogen (estrogen cypionate) is an option now that patch shortages are happening– Pellets are not recommended by Dr. K, injectables or creams only– Always monitor labs and adjust based on individual response
🔬 SS-31 vs MOTS-c, setting the record straight– MOTS-c does not create more mitochondria, it reroutes energy. Dr. K has reviewed 80% of MOTS-c studies and finds no evidence it makes more mitochondria– SS-31 stabilizes cardiolipin in the mitochondrial membrane, which is how ATP production is stabilized. This is the real deal– Every person over 40 should consider SS-31 for longevity
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