EP 124: Your Gut Gets Jet Lag Too [ft. Dr. Monisha Bhanote]

You took the probiotic, you paid for the gut test, and you still can't go on vacation. Here's what's actually happening in there.

Kyle Hulbert and theosteodoc, Dr. Benjamin "Dr. K" Kosubevsky, sit down with Dr. Monisha Bhanote 🌟 board-certified five times over, in anatomic pathology, clinical pathology, cytopathology, integrative medicine, and culinary medicine🌟 and get into gut health:

👉 Which tests are actually validated 👉 Why interpreting a result is harder than running it 👉 What "leaky gut" really means when a pathologist explains it 👉 Why most people taking probiotics probably shouldn't be 👉 Why she almost never reaches for antibiotics or antifungals. 👉 And more!

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⏱️ CHAPTERS 00:00 Intro + Disclaimer 00:55 Five Board Certifications Explained 01:31 The Biggest Gut Health Misconception 02:32 Which Gut Tests Are Actually Validated 04:25 Differences in Gut Health Experts 04:56 Why She Doesn't Use Antibiotics or Antifungals 05:12 Where Gut Microbiome Research Actually Stands 06:21 How Do Toxins Affect Gut Health? 08:34 What Leaky Gut Actually Means 09:31 The Soldiers Analogy for Leaky Gut 11:08 Why Probiotics Are the Wrong First Move 12:08 Why Standard Parasite Tests Miss Things 12:40 [Story] The Forgotten Malaria Case 14:30 How to Detect Chronic Parasites 15:18 Should You Be On Probiotics 17:34 Fecal Matter Transplants 19:15 What Flying Does to Your Digestion 21:39 Gut Jet Lag and the 2025 Research 24:49 Constipation on Flights 22:27 Travel Brain Fog and Oxygen 23:16 Best Botanicals for Travel 23:52 Outro + Disclaimer

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🔑 KEY TAKEAWAYS - Running a gut test is the easy part... interpreting it is where most people fail, and it's why so many end up cycling through practitioner after practitioner without getting better

- "Leaky gut" is real and has a real name: increased intestinal permeability. IIP has real causes such as medications, food additives, alcohol, infections, and chronic disease

- Probiotics are not a default fix. Food sources like yogurt, kefir, sauerkraut, kimchi should be a focus, with supplements only when testing shows something is genuinely missing

- If you do take probiotic supplements, rotate the strains rather than staying on the same ones indefinitely

- Probiotic capsules likely won't survive a flight, so they're not the travel tool people think they are: magnesium bisglycinate and ginger are more practical

- Your gut microbiome runs on its own circadian clock, which is why travel disrupts digestion before you notice anything else. (This one was new to us too)

- Fecal matter transplants are early enough that screening standards aren't where blood banking landed after decades. So, worth watching, not worth rushing.

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📚 STUDIES MENTIONED Li J, et al. "Gut jet lag: how circadian rhythm disruption undermines the Chrono-Microbiota-Motility axis and induces functional constipation." Frontiers in Nutrition, 2025. https://doi.org/10.3389/fnut.2025.1678482

⚠️ ONE CORRECTION: In the episode, we say gut organisms outnumber human cells about two to one. That figure has been revised — Sender, Fuchs, and Milo (PLOS Biology, 2016) put it closer to 1:1, roughly 38 trillion bacterial cells to 30 trillion human ones. The point stands that there are a staggering number of them; the ratio is just smaller than the number that gets repeated. https://doi.org/10.1371/journal.pbio.1002533

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🔍 Relevant To Us and This Video #GutHealth #Microbiome #LongevityUnlocked #LongevityClinic #LeakyGut #GutTesting #guthealing #probiotics #guthealthtips

📲 People & Social Links Website: https://www.thelcoa.com/longevity-unlocked-podcast/ Podcast: @longevityunlockedpod (https://www.instagram.com/longevityunlockedpod/) Dr. K on Instagram: @theosteodoc Guest: Dr. Monisha Bhanote — https://www.drbhanote.com | @drbhanote

Credits Produced by: The Longevity Centers of America in collaboration with the sHealed team Filmed in Cannes, France [https://www.imdb.com/title/tt33144483/]