Cryoanalgesia for pain management after pectus excavatum repair in adolescents

Cryoanalgesia for pain management after pectus excavatum repair in adolescents

Citation:

Bastianello M, Torre M, Bonfiglio R, Calevo MG, Palomba L, Uva P, et al. Cryoanalgesia for Pain Management After Pectus Excavatum Repair (COPPER) in Adolescents: A Randomized Controlled Trial. Pediatric Anesthesia. 2025;35:347–358. doi:10.1111/pan.15090.

Study at a glance

- Design and setting: Single-centre parallel-group RCT (Italy) in adolescents (≥12 years) undergoing elective MIRPE (N=88).

- Interventions: Thoracoscopic intercostal cryoanalgesia plus standard multimodal analgesia vs thoracic epidural infusion (levobupivacaine–clonidine) plus the same systemic regimen.

- Primary outcome (14-day PedsQL total): Median 67.9 with epidural vs 59.8 with cryoanalgesia; mean difference 6.5 points (95% CI −0.46 to 13; p=0.067) — no clear superiority; low-certainty evidence.

Key secondary: Length of stay shorter with cryoanalgesia (3.4 vs 4.4 days; moderate-certainty evidence); immediate pain at awakening lower with epidural (NRS approximately 3 vs 5).

- Safety: Overall medical/surgical complications were uncommon and similar; thoracic sensory changes at about three months were frequent in both groups, with more hypo-aesthesia after cryoanalgesia.

Denne episoden er hentet fra en åpen RSS-feed og er ikke publisert av Podme. Den kan derfor inneholde annonser.

Episoder(30)

Low-dose intrathecal morphine versus intrathecal fentanyl for post-caesarean analgesia in a resource-constrained setting: a pragmatic randomised trial

Low-dose intrathecal morphine versus intrathecal fentanyl for post-caesarean analgesia in a resource-constrained setting: a pragmatic randomised trial

Citation:Chetty S, Paruk F, Kamerman P. Low-dose intrathecal morphine versus intrathecal fentanyl for post-caesarean analgesia in a resource-constrained setting: a pragmatic randomised trial. BMC Anes...

28 Jun 8min

Residual gastric content after holding of glucagon-like peptide-1 receptor agonists before elective surgery: a cross-sectional study - The RESIDUAL study

Residual gastric content after holding of glucagon-like peptide-1 receptor agonists before elective surgery: a cross-sectional study - The RESIDUAL study

Citation:Boudreau C, Couture M, Rousseau-Saine N, Laferrière-Langlois P, Roy-Renaud É, Burey J, et al. Residual gastric content after holding of glucagon-like peptide-1 receptor agonists before electi...

21 Jun 8min

Prospective Evaluation of Routine Extubation Criteria in Children with Upper Respiratory Symptoms Undergoing Elective Surgery

Prospective Evaluation of Routine Extubation Criteria in Children with Upper Respiratory Symptoms Undergoing Elective Surgery

Citation:Templeton TW, Smith LD, Mosher T, Saha AK, Hodges AS, Vishneski SR, et al. A Prospective Evaluation of Routine Extubation Criteria in Children with Upper Respiratory Symptoms Undergoing Elect...

14 Jun 8min

Environmental and economic impacts of anaesthesia: A simulation study comparing total intravenous anaesthesia versus sevoflurane for maintenance of anaesthesia in 11 909 adult patients of a Belgian tertiary hospital

Environmental and economic impacts of anaesthesia: A simulation study comparing total intravenous anaesthesia versus sevoflurane for maintenance of anaesthesia in 11 909 adult patients of a Belgian tertiary hospital

Citation:Van Belleghem F, Rex S, Teunkens A, Vereecke H, Kalmar AF. Environmental and economic impacts of anaesthesia: A simulation study comparing total intravenous anaesthesia versus sevoflurane for...

7 Jun 8min

An interpretable machine learning model for predicting emergence agitation in children: a multicenter development and validation study

An interpretable machine learning model for predicting emergence agitation in children: a multicenter development and validation study

Citation:Zhao Q, Zhang Y, An R, Yi B, Huang G. An interpretable machine learning model for predicting emergence agitation in children: a multicenter development and validation study. BMC Anesthesiol. ...

17 Mai 11min

Clinical Performance in Critical Care Simulation Under Sleep Deprivation: Effects of Power Napping in the R-NAP Randomized Controlled Trial

Clinical Performance in Critical Care Simulation Under Sleep Deprivation: Effects of Power Napping in the R-NAP Randomized Controlled Trial

Citation:Schmidt L, Genty F, Delaire T, Valero B, Rey I, Galan L, Mairet-Mabboux S, Douplat M, Schlatter S, Rimmele T, Mazza S, Lilot M. Clinical Performance in Critical Care Simulation Under Sleep De...

10 Mai 10min

Outcome Differences Between General and Neuraxial Anesthesia for Hip Fracture by Frailty and Age in the Elderly: A Retrospective Cohort Study

Outcome Differences Between General and Neuraxial Anesthesia for Hip Fracture by Frailty and Age in the Elderly: A Retrospective Cohort Study

Citation:Giannakis P, Restrepo M, Stone AB, Zhuang ST, Wang J, Cozowicz C, et al. Outcome Differences Between General and Neuraxial Anesthesia for Hip Fracture by Frailty and Age in the Elderly: A Ret...

3 Mai 11min

Effect of low-dose propofol infusion with sevoflurane versus propofol-only total intravenous anesthesia on postoperative nausea and vomiting in high-risk patients: a single-blind randomized controlled clinical trial

Effect of low-dose propofol infusion with sevoflurane versus propofol-only total intravenous anesthesia on postoperative nausea and vomiting in high-risk patients: a single-blind randomized controlled clinical trial

Citation:Keck WL, Deng E, Liu WM, Kanekar R, Lomivorotov V, Sharma S. Effect of low-dose propofol infusion with sevoflurane versus propofol-only total intravenous anesthesia on postoperative nausea an...

26 Apr 9min

Populært innen Vitenskap

fastlegen
romkapsel
tingenes-tilstand
liberal-halvtime
rss-paradigmepodden
vett-og-vitenskap-med-gaute-einevoll
rekommandert
sinnsyn
rss-nysgjerrige-norge
fjellsportpodden
jss
rss-rekommandert
villmarksliv
tidlose-historier
smart-forklart
nordnorsk-historie
dekodet-2
forskningno
rss-overskuddsliv
diagnose