Dr. Saranya Wyles, MD, PhD: Skin Aging, Senescent Cells, Botox and Regenerative Dermatology

Dr. Saranya Wyles, MD, PhD: Skin Aging, Senescent Cells, Botox and Regenerative Dermatology

Most anti-aging skincare focuses on wrinkles after they appear. Skin longevity starts much earlier, with the biology that determines how well skin repairs itself, maintains collagen, responds to hormones, and clears damaged or senescent cells.

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I sat down with Dr. Saranya Wyles, MD, PhD, a Mayo Clinic dermatologist and regenerative medicine researcher, to separate useful science from a category full of hype. We cover sunscreen, visible light, facial estrogen, exercise, sauna, Botox, microcurrent, radiofrequency, retinol, exosomes, and the treatments that may support healthier skin over time.

We also explore why women's skin changes during menopause and across the menstrual cycle, how bone and facial fat influence visible aging, and why the right intervention depends on the decade, the tissue, and the problem you are actually trying to solve.

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Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&As, the latest female longevity science, and a private, supportive community of like-minded women.

https://kayla-barnes-lentz.circle.so/female-longevity-community

In This Conversation:

  • How senescent cells affect skin aging and repair

  • Why menopause accelerates collagen and skin changes

  • What sunscreen, antioxidants, and physical barriers actually do

  • Botox, facial exercises, microcurrent, and in-office devices

  • Retinol, exosomes, PRP, and regenerative skincare

  • How exercise, sleep, sauna, and the microbiome affect skin


Connect with Kayla:

Instagram: https://www.instagram.com/kaylabarnes/

TikTok: https://www.tiktok.com/@femalelongevity

Twitter:https://x.com/femalelongevity

Website:https://www.kaylabarnes.com/

Spotify:https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054

Apple:https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227

Follow Her Female Protocol: https://www.protocol.kaylabarnes.com


Learn More About Dr. Saranya Wyles:

Mayo Clinic Profile: https://www.mayoclinic.org/biographies/wyles-saranya-p-m-d-ph-d/bio-20518649

Instagram: https://www.instagram.com/drwyles.derm/

LinkedIn: Saranya Wyles, M.D., Ph.D. | LinkedIn

X: https://x.com/drwyles_derm

#femalelongevity #skinlongevity #dermatology #senescentcells #skinaging #sunscreen #longevity #skincareroutine #hormonehealth #wellness


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Episoder(174)

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17 Sep 1h 7min

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We talk about aging like it happens to a whole person at once. It doesn't. It happens organ by organ, at different speeds, and most people never find out which part of them is running ahead until some...

10 Sep 1h

Dr. Tania Dempsey, MD: Mast Cell Activation Syndrome, PMOS, and the Hidden Cause of Women's Chronic Symptoms

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Most women who deal with unexplained allergies, stubborn inflammation, heavy periods or a PMOS (formerly PCOS) diagnosis are never told to look at the same underlying cause: an immune cell most doctor...

3 Sep 1h 17min

Dr. Margie Davenport, PhD: Exercise in Pregnancy, the 140 BPM Myth, and Why Pregnancy Complications Predict Heart Disease

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Pregnancy has long been treated as a season to slow down and play it safe. The data tells a different story, and it starts with a number most women were taught to fear.Dr. Margie Davenport, PhD, is an...

27 Aug 59min

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