#13 - Deborah Mash: The Lioness of Ibogaine Research
Ibogaine Uncovered8 Jun 2023

#13 - Deborah Mash: The Lioness of Ibogaine Research

Dr. Deborah Mash is a pioneering researcher of ibogaine and one of the world’s foremost experts on the drug. She is a professor (emeritus) of neurology and molecular and cellular pharmacology at the University of Miami School of Medicine, and the founder and CEO of DemeRx, a company developing treatments for opioid use disorder.

What we discuss:


  • How Dr. Mash first became interested in ibogaine, including her connection to Howard Lotsof, an early ibogaine advocate

  • The structure of the ibogaine molecule and what makes it unique from other psychedelics

  • Dr. Mash’s early research: the first clinical studies of ibogaine in humans

  • Noribogaine: what it is and what it does

  • Ibogaine fatalities: is everyone who takes it is at equal risk of death?

  • How far have we come in terms of reframing our view of substance use disorder?

  • If ibogaine was rescheduled, what could the future of treatment look like?

Why it’s important:

In the excitement of the psychedelic renaissance, it can feel like all of this is “new.” It’s often said that there isn't enough research to support the use of ibogaine in a clinical setting, but Dr. Mash’s work is part of a growing body of evidence that proves otherwise. Reconciling her work and the stories you’ve heard on this show with the fact that ibogaine is still a Schedule I substance in the United States – meaning it has no medical value and a high potential for abuse – is hard to do. Understanding and working to change drug policy through research is a long game. We’re lucky that an expert like Dr. Mash is staying on the field.

Relevant Links:

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