#17 - Dr. Gül Dölen: Can Ibogaine Open Critical Periods?

Dr. Gül Dölen, MD, PhD, is an associate professor of neuroscience at Johns Hopkins University. In her lab, her team focuses on how the brain enables social behaviors through basic neurobiological processes such as neuromodulation and synaptic plasticity. Dölen has led several headline-making studies in the psychedelic field, including one in 2018 that involved giving MDMA to octopuses, and a more recent study that revealed psychedelics can reopen the “critical period” in the brain.

What we discuss:

• How Dr. Dölen became interested in studying psychedelics after focusing on learning and memory as well as the pathogenesis of autism

• The study that turned things around: why study the effects of psychedelics in an evolutionarily distant species like the octopus?

• What giving octopuses MDMA revealed about their normally solitary behavior

• The implications in the world of psychedelic science after studying their effects on this kind of animal

• Defining critical periods: What are they? What are the benefits of experiencing a critical period?

• Dr. Dölen’s hypothesis: Could psychedelics be the “master key” to reopening critical periods?

• Which drugs are best at reopening critical periods? Where does ibogaine stand?

• Are there any risks associated with experiencing an abundance of critical periods?

• The problem with the word ‘plasticity’

Why it’s important:

Dr. Dölen’s pioneering research–both the study of MDMA in octopuses and her more recent work on unlocking critical periods–allows us to look at psychedelic drugs in different ways: in evolutionarily distant species with entirely different brain structures, and as “master keys” that could potentially unlock those periods. While there aren’t many studies that put different psychedelic drugs on a spectrum of efficacy, her work shows that among MDMA, LSD, psilocybin, and ketamine, ibogaine leads the way when it comes to opening critical periods – a piece of information that (hopefully) encourages more scientists in the psychedelic space to study this powerful medicine.

Relevant Links:

• Dr. Dölen’s faculty profile on Johns Hopkins
• Dr. Dölen, Center for Psychedelic & Consciousness Research, JHU
• Spectrum News: In Deep Water with Gül Dölen
• The Tim Ferriss Show: Dr. Gül Dölen
• dölenLAB
• Nature: Octopuses on ecstasy just want a cuddle
• Wired: The Psychedelic Scientist Who Sends Brains Back to Childhood
• The Microdose: 5 Questions for Gul Dolen