1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

Ryan Holiday (@ryanholiday) is the bestselling author of Trust Me, I'm Lying; The Obstacle Is the Way; Ego Is the Enemy; Conspiracy, and other books about marketing, culture, and the human condition. His latest offering is Stillness Is the Key. What We Discuss with Ryan Holiday: How successful people learn to process feedback -- and consider its source in order to improve and move forward. Why self-awareness is the secret weapon of some of the highest-performing people you'll meet. What can keep us striving and moving upward in a world where it's way too easy to compare ourselves to one another and beat ourselves up in the process. How Ryan found the purpose and motivation to write eight books and ghost write another six by the time he was 30. The eerie, intuitive, borderline magical superpowers of Mr. Rogers, Cesar Millan, and the two daycare miracle workers who can put 15 toddlers down for a nap (including Ryan's son) simultaneously every day. And much more... Full show notes and resources can be found here: https://jordanharbinger.com/271 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Join entrepreneur, technology investor, and self-experimenter Kevin Rose as he explores new ways to reach peak personal and professional performance on The Kevin Rose Show -- listen here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

31 Okt 20191h 15min

Ben Horowitz (@bhorowitz) is a founding partner of superstar venture capital firm Andreessen Horowitz, and the author of NYT Best Seller The Hard Thing About Hard Things: Building a Business When There Are No Easy Answers and his latest, What You Do Is Who You Are: How to Create Your Business Culture. What We Discuss with Ben Horowitz: What the Haitian slave revolt can teach us about creating a thriving, resilient company culture from chaos. Why a company's culture -- for better or worse -- will endure in the memory of the people who work there far longer than the consequences of a bad quarter. The disasters that strike when a company's core values and culture reveal their dark side. How prison culture influences the way some billion dollar tech companies are managed. Ben's possibly surprising musical preferences and how they fuel his own creative direction. And much more... Full show notes and resources can be found here: https://jordanharbinger.com/270 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! On No Dumb Questions, a science guy from the deep south (Destin of Smarter Every Day) and a humanities guy from the wild west (Matt Whitman of The Ten Minute Bible Hour) discuss deep questions with varying levels of maturity. Give No Dumb Questions a listen here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

29 Okt 201949min

Your stepdaughter is 14 and has been living full time with you and your husband for about eight years. Every other weekend she spends with her mom, who you know is a sex worker. The stepdaughter just says her mom works away, but doesn't know what she does. Recently you were sent a screenshot of a Facebook post from another mom in your stepdaughter's class asking if it was real. The post had an ad for your stepdaughter's Mom's "services." You haven't answered yet because you don't know what to say. Since it's out on Facebook, should you give the stepdaughter a heads up that her mom takes money for sex, or do you let her get blindsided by the kids in school? On this Feedback Friday, we'll try to help you do the right thing here. And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Jason DeFillippo (@jpdef) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: https://jordanharbinger.com/269. On This Week's Feedback Friday, We Discuss: Interested in doing some prison time with Jordan next February? It's filling up fast; reach out to prison@jordanharbinger.com for details! Unknown to her, your stepdaughter's biological mother is a sex worker. Now that busybodies in your town have found out, should you tell her before she finds out from her bullying classmates? You're forced to interact often with someone who doesn't respect your time and keeps you locked in long, boring conversations for what adds up to about three hours a week. What's your best escape plan? Your fiance's sister moved to a new city and hasn't had much success with networking. As far as you know, she hasn't made any friends, isn't dating, and doesn't have any hobbies. You want to help her, but you're not sure how. What do we suggest? When you have new coworkers who seem to go out of their way to exclude you from their conversations, it's hard not to take it personally. What can you do, if anything, to cope with cliques in the workplace? You've found a job for which you'd love to apply, but the company is requiring a cover letter with pay requirements. Is there a comfortable middle ground you can ask for that doesn't make you seem overzealous? You're analytical, and your spouse is emotional. You usually play off of each other's strengths, but you're currently in a conversational stalemate in which you feel like your spouse is treating you like a jerk for just trying to help. What's really going on here? You recently graduated from a great school, but you've only managed to get a handful of interviews and no offers over the last several months. Your confidence and resources are dwindling and you don't know what else to do. How can you keep your spirits up while finding your bearings? What does cultivating relationships through networking when you're just... See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Okt 201950min

Robert Spalding (@robert_spalding) is a national security strategist and a globally recognized expert on Chinese economic competition and influence. He retired from the US Air Force as a brigadier general, and is the author of Stealth War: How China Took Over While America's Elite Slept. What We Discuss with Robert Spalding: The consequences the United States faces as a result of its economic connections to a totalitarian state that openly opposes its core values. How electronics and sensors are being created for American consumers that send data to China to feed the government's artificial intelligence systems. Why there can't be a global free market system when the second biggest economy in the world isn't participating. How US manufacturing suffers as a result of consumer demand for "cheap stuff" that China is more than happy to fulfill. China's fraudulent accounting methods, akin to a ponzi scheme, that actively erode the US economy with assistance from the very people this hurts. And much more... Full show notes and resources can be found here: https://jordanharbinger.com/268 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Join entrepreneur, technology investor, and self-experimenter Kevin Rose as he explores new ways to reach peak personal and professional performance on The Kevin Rose Show -- listen here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

24 Okt 20191h 1min

Brian Grazer (@BrianGrazer) is an Academy Award-winning producer whose films and TV shows have been nominated for 45 Academy Awards and 196 Emmys. He is the author of Face to Face: The Art of Human Connection. What We Discuss with Brian Grazer: What imposter syndrome looks like when you're at the top of the Hollywood game. How Brian turned a childhood learning disability into a superpower. Why being called a loser by Harvey Weinstein at the 1996 Academy Awards doesn't Brian hurt so much these days. How Brian networked himself up from legal clerk at Warner Bros. to one of Hollywood's most respected producers. Why Brian values curiosity over IQ. And much more… Full show notes and resources can be found here: https://jordanharbinger.com/267 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! On No Dumb Questions, a science guy from the deep south (Destin of Smarter Every Day) and a humanities guy from the wild west (Matt Whitman of The Ten Minute Bible Hour) discuss deep questions with varying levels of maturity. Give No Dumb Questions a listen here! Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

22 Okt 201957min

Recently you stopped all contact with a childhood friend due to his toxic behavior. He went through a pretty bad breakup due to his behavior and you had enough. He thinks that by being a horrible dick to people, he's being really honest and helping them. Your other friends tell you that you should talk to him about why you cut him off, but you feel you've told him one too many times why he's a dick and what he could do to change. Do you owe him a conversation just because you were childhood friends? On this Feedback Friday, we'll try to help you decide whether to continue ghosting this ex-friend or actually take the time to tell him he's a horrible person. And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Jason DeFillippo (@jpdef) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: https://jordanharbinger.com/266. On This Week's Feedback Friday, We Discuss: Interested in doing some prison time with Jordan next February? It's filling up fast; reach out to prison@jordanharbinger.com for details! Recently you stopped all contact with a childhood friend due to his toxic behavior. Do you owe him a conversation just because you were childhood friends -- even if it's just to tell him he's a horrible person? You've grown distant from your once-close sibling, who has become increasingly anxious and self-isolated to the point where family visits never happen anymore. Is there a way you can help draw them out? Your boyfriend enjoys porn, so you're wondering -- from a guy's perspective -- why is it necessary to have an “escape” from a relationship with a partner who is perfectly willing to do it all? Is he just scared to be vulnerable enough to ask you? After six potential relationships got nipped in the bud because the other person says you're "too good" for them, your suspicions are aroused. What's the most likely story, and what can you do to change this all-too-familiar outcome? When you work in politics and it's election season, how do you wrangle your campaign volunteers to do the work that's proven effective (phone calls and knocking on doors) instead of the work they want to do (strategy meetings and social media)? You're constantly told you need to meet with mentors, but you've gotten a lot of terrible advice from them. Is there any value to just going through the motions with bad mentors who may be great connections if not the soundest strategists? You're a shoe-in for a job opportunity opening near you soon, but it would mean pulling out of a job you're not that excited about that requires a lengthy commute. How can you let go of the latter job without leaving anyone in the lurch? Life Pro Tip: Feeling a gag reflex? Squeeze your fist really... See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Okt 201948min

Moran Cerf (@twtrdtcm) is a neuroscientist who strives to understand the underlying mechanisms of human psychology, behavior changes, emotion, decision making, and dreams. What We Discuss with Moran Cerf: What would a future in which we could connect our brains to the cloud and outsource parts of our thinking look like? Can we — or will we ever be able to — record and share our dreams like home movies of the most intimate kind? How teachers might use virtual reality attuned to our specific brain engagement patterns to ensure we're learning at an optimal rate. What happens when computers and machines can read our thoughts and know what we're thinking even before we do? What are the security risks of having our thoughts available to these kinds of networks? And much more… Full show notes and resources can be found here: https://jordanharbinger.com/265 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Join entrepreneur, technology investor, and self-experimenter Kevin Rose as he explores new ways to reach peak personal and professional performance on The Kevin Rose Show — listen here! Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

17 Okt 20191h 4min

Mike Rowe (@mikeroweworks) is a host and narrator known for his work on Dirty Jobs, Somebody's Gotta Do It, The Way I Heard It Podcast, and Returning the Favor. He is also now an author, and his first book, The Way I Heard It, is out now. What We Discuss with Mike Rowe: The kind of cognitive dissonance Mike believes our country needs right now, and the tropes we could afford to grasp more loosely. How the prevailing desire among correction culture commandos to prove others wrong on the Internet stifles our ability to exchange ideas freely. Why Mike eschews second takes in favor of presenting his audience with the authentic moments they trust him to share. How Mike's thrifty (and crafty) parents suckered him into feeling sorry for rich people when he was growing up. Why we shouldn't view a blue collar career pursuit as a cautionary tale in comparison to the lifelong debt likely incurred by chasing a four-year degree these days. And much more… Full show notes and resources can be found here: https://jordanharbinger.com/264 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! On No Dumb Questions, a science guy from the deep south (Destin of Smarter Every Day) and a humanities guy from the wild west (Matt Whitman of The Ten Minute Bible Hour) discuss deep questions with varying levels of maturity. Give No Dumb Questions a listen here! Like this show? Please leave us a review here — even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

15 Okt 20191h 12min