1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

Shawn Achor (@shawnachor) is one of the world’s leading experts on the connection between happiness and success, and is the author of Big Potential, Before Happiness, and The Happiness Advantage: How a Positive Brain Fuels Success in Work and Life. What We Discuss with Shawn Achor: What did Shawn have to teach Pentagon bigwigs about happiness? The science behind the contagiousness of happiness. The importance of mirror neurons. What is the 10-5 Way, and how can it improve your life? At what point in her career was Oprah most depressed, and why should you care? And much more... Full show notes and resources can be found here: jordanharbinger.com/614 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Miss our conversation with Arthur Brooks about the merits of learning to love your enemies (especially during these divisive times)? Catch up by listening to episode 211: Arthur Brooks | How Loving Your Enemies Can Save America here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

20 Jan 202249min

Ray Dalio (@RayDalio) is the founder of Bridgewater Associates — the largest and best-performing hedge fund in the world — and author of New York Times bestseller Principles: Life and Work. His latest book is The Changing World Order: Why Nations Succeed and Fail. What We Discuss with Ray Dalio: What an investor like Ray Dalio is uniquely poised to observe about the ebb and flow of history and the repeating patterns that make the future somewhat predictable. Why transitional (and often painful) cycles -- like recessions, pandemics, and wars -- are necessary to reset and change the rules. How studying these cycles as symptomatic of larger problems is the best way to heal and grow from their discomfort. What the current state of political polarization in the United States bodes for our collective future. How our rivalry with China differs from our Cold War rivalry with the Soviet Union and what Ray sees as our best way of managing it. And much more... Full show notes and resources can be found here: jordanharbinger.com/613 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! If you missed the last time Ray Dalio was on the show, make sure to catch up with episode 491: Ray Dalio | The Changing World Order here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Jan 20221h 15min

Your mom and stepdad split up when she caught him trying to take pictures of you -- at age 16 -- in the shower. Now he's remarried with new stepchildren and a baby on the way. How can you warn his new family about his predatory proclivities before he ruins their lives too? This and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/612 On This Week's Feedback Friday, We Discuss: The stepdad who was caught trying to take pictures of you in the shower when you were a teenager now has a new family, new stepchildren, and a new baby on the way. How can you prevent him from preying on them? You've discovered hard evidence that your toxic, soon-to-be-ex-business partner is guilty of fraud. The vengeful part of you really wants to report her to the authorities, but you don't want your other partner, who you like and respect, to suffer blowback. What's the right thing to do? Your significant other's anxiety has only gotten worse over the years, and their constant need for validation and reassurance is draining. How can you support their quest to become mentally healthier without becoming emotionally exhausted yourself? You consider yourself a strong, knowledgeable, take-no-crap woman, but you've been fired from two jobs this year for "not fitting with company culture." So you started your own business, which you love, but you can't overcome the guilt of providing less for your family than you did as someone else's unsatisfied employee. What should you do? You really do love your future mother-in-law, but you're not jazzed about her plans to live in your backyard guesthouse permanently when you tie the knot with her son. Is it wrong for you to want boundaries between yourself and your extended family while building a family of your own? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

14 Jan 202248min

Reid Hoffman (@reidhoffman) is a co-founder of LinkedIn, investor at Greylock Partners, host of the podcast Masters of Scale, and co-author of Masters of Scale: Surprising Truths from the World's Most Successful Entrepreneurs. What We Discuss with Reid Hoffman: What Reid means when he calls himself a "six-person-or-less extrovert." Why fostering diversity is important for any company that wants to be relevant tomorrow. How to identify the five kinds of "no" and what they can each teach you. Why unanimous consent in a pitch meeting is a concerning sign. The best and worst ways to pitch ideas to venture capitalists. And much more... Full show notes and resources can be found here: jordanharbinger.com/611 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Miss our conversation with comedian, actor, and director Bob Saget? Catch up with episode 372: Bob Saget | How Comedy Continually Changes His Life here. Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

13 Jan 202255min

Bill Sullivan (@wjsullivan) is a professor of pharmacology and microbiology at the Indiana University School of Medicine in Indianapolis, an award-winning researcher, teacher, science communicator, and author of Pleased to Meet Me: Genes, Germs, and the Curious Forces That Make Us Who We Are. What We Discuss with Bill Sullivan: What we're just now learning in the field of epigenetics -- the study of how your behaviors and environment can cause changes that affect the way your genes work. Why twins who are genetically identical look less alike as they age -- or if they've been raised apart from one another. How the overabundance of plastics and other endocrine disruptors in our environment are affecting not only our bodies on a molecular level, but the physical and mental development of generations down the line. How kids -- even the unborn -- are epigenetically altered by the social and economic status of their parents. What we're learning about the role of the teeming millions of microorganisms that live inside of us -- collectively known as the microbiome -- on our overall mental and physical health. And much more... Full show notes and resources can be found here: jordanharbinger.com/610 Sign up for Six-Minute Networking — our free networking and relationship development mini course — at jordanharbinger.com/course! Miss our interview with Find Your Why, Start with Why, and The Infinite Game author Simon Sinek? Catch up with episode 300: Simon Sinek | How to Play the Infinite Game here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

11 Jan 20221h 15min

The tenant renting your upstairs room has become so paranoid and delusional that you and your spouse no longer feel safe in your own home. On top of this, he has no job, no car, and he's behind on the rent. You don't want to be the heartless landlord who evicts someone so clearly in need of help, but you also don't want to wait until his erratic outbursts become violently directed toward you or your wife. So what's the right thing to do here? We'll try to find answers to this and more on this, our first Feedback Friday of the new year! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/609 On This Week's Feedback Friday, We Discuss: How do you evict the mentally unstable boarder who makes you feel unsafe in your own house without also being heartless? [Thanks to attorney Corbin Payne for helping us field this one!] With a desire to "fix" the problems of others where you find them, you seem to get romantically involved with a lot of emotionally dysfunctional narcissists. What can you do to break this lamentable pattern? [Thanks to clinical psychologist Dr. Erin Margolis for helping us with this one!] In conversation, you often find yourself thinking of something to say before the other person has finished talking. And when it is your chance to speak, you're painfully aware that you're speaking too much. How do you strike a better balance of active listening and speaking succinctly? In your senior year of high school, you're hopelessly overwhelmed. If you crush one deadline, another one looms nearby to crush your spirit. Your willpower is low, you're neglecting basic self-care, and procrastination is always more appealing than productivity. Do you truly need a break, or are you just being lazy? As an underling ascending the corporate ladder, you found certain aspects of company culture a bit cringy and borderline cult-like. Now that you've started your own business, you want to create a company culture that builds rapport and teamwork while avoiding these pitfalls. But how? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

7 Jan 202253min

Jocko Willink (@jockowillink), commander for the most highly decorated special operations unit of the Iraq War, joins the show to talk about taking responsibility, discipline, intensity, and leadership to the next level as outlined in Extreme Ownership: How U.S. Navy SEALs Lead and Win. [Note: This is a previously broadcast episode from the vault that we felt deserved a fresh pass through your earholes!] What We Discuss with Jocko Willink: When making a decision, worrying about variables that can’t be controlled is a waste of time. A better outcome is likely if we learn to focus that wasted effort on factors that can be controlled. Understand why taking ownership of your mistakes, personal issues, and outcomes gets better results than trying to pass the blame to someone else. What does discipline = freedom mean? How do you stop small weaknesses that sometimes permeate discipline from having a negative impact on significant decisions? Is there such a thing as a natural leader? And much more... Full show notes and resources can be found here: jordanharbinger.com/608 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Miss our conversation with accidental international poker champion and human motivation expert Maria Konnikova? Catch up with episode 371: Maria Konnikova | Pulling Off the Biggest Bluff here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

6 Jan 20221h 19min

Dwyane Wade (@DwyaneWade) is a retired NBA All-Star, host of The Cube on TBS, and author of Dwyane and A Father First: How My Life Became Bigger Than Basketball. What We Discuss with Dwyane Wade: How to know the difference between giving your kids the opportunity to excel in areas that will enrich their lives versus pushing them into things they don't want to do. Lessons Dwyane learned from the basketball court that he now applies to his most important job: parent. How Dwyane dealt with imposter syndrome on the cusp of signing to the NBA. On the stigma of athletes seeking help for mental health, and why Dwyane encourages them to do it anyway. How Dwyane encourages his kids to be the best versions of themselves, strives to see the world from their unique perspectives, and doesn't shy away from consulting professional help when they pose questions he's unable to answer on his own. And much more... Full show notes and resources can be found here: jordanharbinger.com/607 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Miss our conversation with rapper, singer-songwriter, and record producer T-Pain? Catch up with episode 551: T-Pain | You Can’t Auto-Tune Your Way to Happiness here! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

4 Jan 202245min