1005: David Fajgenbaum | Leveraging AI to Cure Rare Diseases

You love jumping out of random hiding places in your house to startle your fiancée, but your fiancée does not share your enthusiasm for this "hobby" and wants you to knock it the heck off. You understand your boo's rightful vexation over this frightening fixation, but you can't seem to stop. Is this a common problem? We'll tackle this and more here on our special Day-After-April-Fool's-Day episode of Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/490 On This Week's Feedback Friday, We Discuss: Jordan shares a story about the time he thought he was going to get arrested at the donut shop in the middle of the night. You think you might be addicted to the thrill of jumping out of random hiding places in your house to startle your fiancée, because now you can't stop (even though she really, really wants you to). Is this a "normal" problem? Do Jordan and Gabe brush their teeth and floss every day? What have been Jordan's best and worst interviews? Does he stay friends with any of them afterward? What are the strangest things Gabe and Jordan know how to do? How do Jordan and Gabe feel about psychedelics? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider leaving your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

2 Apr 20211h 7min

Frank Bourassa counterfeited and sold $250 million in fake US currency until he was nabbed in an undercover operation. Now he runs a security company and works with the police to catch other counterfeiters. What We Discuss with Frank Bourassa: How someone creates a quarter of a billion dollars in American $20 bills that not only look genuine, but feel genuine even to experts. The hours of research that Frank spent learning how to create counterfeit money that would pass most muster without immediately going to jail on his first attempt. The catalyst that drove Frank to pursue a life of crime in the first place (and has probably tempted most of us to consider it from time to time). It takes money to make money: Frank reveals the startup fees that went into his operation to literally print the perfect $20 bills en masse. How much labor actually goes into a counterfeiting project at this scale -- once you find a crew you think you can trust. And much more... Full show notes and resources can be found here: jordanharbinger.com/489 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

1 Apr 202158min

Frank Bourassa counterfeited and sold $250 million in fake US currency until he was nabbed in an undercover operation. Now he runs a security company and works with the police to catch other counterfeiters. What We Discuss with Frank Bourassa: How someone creates a quarter of a billion dollars in American $20 bills that not only look genuine, but feel genuine even to experts. The hours of research that Frank spent learning how to create counterfeit money that would pass most muster without immediately going to jail on his first attempt. The catalyst that drove Frank to pursue a life of crime in the first place (and has probably tempted most of us to consider it from time to time). It takes money to make money: Frank reveals the startup fees that went into his operation to literally print the perfect $20 bills en masse. How much labor actually goes into a counterfeiting project at this scale -- once you find a crew you think you can trust. And much more... Full show notes and resources can be found here: jordanharbinger.com/488 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

30 Mar 20211h 3min

You basically grew up in a cult, and following your own path as an adult was seen as an act of "rebellion" in the eyes of your dad, from whom you've been estranged ever since. He's even forbidden you from setting foot on his property until you "repent, return, and remain." Now, years have passed and it doesn't sit well with you that your relationship is so strained. Should you try to reconnect with your cult father, or is it even worth the bother? We'll try to find answers to this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/487 On This Week's Feedback Friday, We Discuss: After "rebelling" against the cult in which you were raised, should you try to reconnect with your estranged father, or is it even worth the bother? [Thanks to cult expert Steven Hassan for helping us with this one!] You fell behind on paperwork your job legally requires, and even though you provided it to the inspectors before the pandemic lockdowns began, you've yet to hear back from them. Now your wife says if it causes you to lose your job, she'll never forgive you. Is she overreacting? How do you handle this? You've got a new, cushy job that pays handsomely, but you're unfulfilled because it's not the work you signed up for. Quitting now means you'd have to pay off thousands in sign-on bonuses, but you feel like you're doing your career a disservice by sticking with it. Should you just shut up and be grateful, or cut your losses and find something that better suits you? Over the past year, you’ve become obsessed with learning. You read books, consume newsletters, and listen to hours of podcasts every day. The bad news: you can't seem to retain any of it. Are you just overloading your brain circuitry, or is there a trick to getting all this new info to stick? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

26 Mar 202151min

Nina Schick (@NinaDSchick) specializes in how technology is transforming geopolitics and society in the 21st century. She is the author of Deepfakes: The Coming Infocalypse. What We Discuss with Nina Schick: What deepfakes are and how they're created using technology that is getting exponentially more sophisticated every year and accessible to anyone. How deepfakes go beyond novelty and into dangerous territory occupied by blackmailers, propagandists, terrorists, conspiracy theorists, and other unsavory ne'er-do-wells who profit by making the rest of us doubt what we can trust as reality. Why deepfakes are so much more concerning than reality-bending manipulations of the past. The potential positive uses of AI-assisted deepfake technology that will change our world as dramatically as the advent of the Internet. How we can discern between real photo, video, or audio footage and imposter deepfakes to avoid being duped by 21st-century technoshysters. And much more... Full show notes and resources can be found here: jordanharbinger.com/486 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

25 Mar 20211h 2min

Leah Remini (@leahremini) is an actor, producer, co-host of podcast Scientology: Fair Game, and co-author of Troublemaker: Surviving Hollywood and Scientology. What We Discuss with Leah Remini: What Scientology is, how it came about, and why it's so dangerous. The lengths the Scientology organization has gone through to protect itself from the government and its disillusioned apostates. How Leah and her Fair Game co-host Mike Rinder have survived the stalking, harassment, and threats of post-Scientology life. What die-hard Scientologists really believe. How Scientology recruits and retains its A-list celebrity lineup. And much more... Full show notes and resources can be found here: jordanharbinger.com/485 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

23 Mar 20211h 3min

Your BFF was slated to be a bridesmaid at your wedding, but she can't resist the urge to argue about politics with you, your fiance, and anyone with whom she disagrees. Now you're wondering: should you even invite her to the wedding at all? We'll dig into this and more here on Feedback Friday! And in case you didn't already know it, Jordan Harbinger (@JordanHarbinger) and Gabriel Mizrahi (@GabeMizrahi) banter and take your comments and questions for Feedback Friday right here every week! If you want us to answer your question, register your feedback, or tell your story on one of our upcoming weekly Feedback Friday episodes, drop us a line at friday@jordanharbinger.com. Now let's dive in! Full show notes and resources can be found here: jordanharbinger.com/484 On This Week's Feedback Friday, We Discuss: Your BFF bridesmaid insufferably loves to argue politics to the point that your fiance can't stand the sight of her. Now you're wondering: should you even invite her to your wedding? Even though you helped your dad build a multi-million dollar business, your long-distance girlfriend's old-fashioned parents don't approve of your relationship. They don't see what you've done as an accomplishment, just that you "work for your dad." What can you do to improve your relationship with people who might someday be your in-laws? You tend to interact with people in a way that some consider being too informal or familiar. Sometimes your sense of humor just doesn't seem to hit the right note and you wind up offending more often than making people laugh. Is there anything you should be doing to make a better impression? Your girlfriend is a magnificent writer, with a master's degree in English, pursuing a career in publishing. Unfortunately, her lack of success in landing a job has sapped her confidence; she won’t reach out to friends and family for support, and is terrified to ask for help. She's even opposed to therapy thanks to bad experiences in the past. What can you do? Have any questions, comments, or stories you'd like to share with us? Drop us a line at friday@jordanharbinger.com! Connect with Jordan on Twitter at @JordanHarbinger and Instagram at @jordanharbinger. Connect with Gabriel on Twitter at @GabeMizrahi. Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider leaving your Twitter handle...See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

19 Mar 202148min

Drew Binsky (@drewbinsky) has been to 194 countries (probably more by the time you're done reading this sentence), shares his prolific adventures on YouTube, and hopes to inspire us all to become better world travelers. Take in the vicarious trips and travel tips with him here! What We Discuss with Drew Binsky: What it's like to spend 24 hours with an isolated tribe of pygmies in the middle of a forest in Africa. The story of Zablon Simintov, the last and only remaining Afghan Jew in the country of Afghanistan. What Drew considers to be the most dangerous country in the world (without even a close second), and how he fared during his six days there. Why the most expensive countries in the world are ones you've probably never heard of. How Drew protects himself when he's traveling in war zones and countries that are particularly hostile toward journalists. And much more... Full show notes and resources can be found here: jordanharbinger.com/483 Sign up for Six-Minute Networking -- our free networking and relationship development mini course -- at jordanharbinger.com/course! Like this show? Please leave us a review here -- even one sentence helps! Consider including your Twitter handle so we can thank you personally!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

18 Mar 20211h 26min