Should pre-transplant MRD be used to guide treatment in AML?
AML Hub25 Jun 2021

Should pre-transplant MRD be used to guide treatment in AML?

During the EHA2021 Virtual Congress, the AML Hub spoke with Charles Craddock, Queen Elizabeth Hospital Birmingham, Birmingham, UK. We asked, Should pre-transplant minimal residual disease (MRD) be used to guide treatment in acute myeloid leukemia (AML)?


Craddock begins by outlining the reasons for the increased use of allogeneic transplant and reviews data that discuss the exclusion criteria and benefits of transplant. He goes on to discuss how patient outcomes could be improved and the importance of post-transplant maintenance. Finally, he highlights the need to generate prospective data, referring to the ongoing studies COSI and AMADEUS.


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Episoder(33)

Symposium | Comparing treatment options for patients with FLT3-ITD and -TKD mutations

Symposium | Comparing treatment options for patients with FLT3-ITD and -TKD mutations

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Symposium | FLT3 mutations in AML: Types, prevalence, and clinical significance

Symposium | FLT3 mutations in AML: Types, prevalence, and clinical significance

The AML Hub held a webinar on November 19, 2025, titled, “Understanding the differences between FLT3-ITD and -TKD mutations in AML: Implications for clinical practice.” Here, we share one of the prese...

14 Jan 16min

ASH 2025 | Pivekimab sunirine + Ven + Aza in unfit patients with ND CD123+ AML: Phase Ib/II efficacy and safety

ASH 2025 | Pivekimab sunirine + Ven + Aza in unfit patients with ND CD123+ AML: Phase Ib/II efficacy and safety

Following the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, December 6–9, 2025, Orlando, US, the AML Hub was pleased to speak with Gail Roboz, Weill Cornell Medicine, New Yo...

13 Jan 8min

ASH 2025 | PARADIGM: Azacitidine + venetoclax vs conventional induction in fit adults with ND AML

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Following the 67th American Society of Hematology (ASH) Annual Meeting and Exposition, December 6–9, 2025, Orlando, US, the AML Hub was pleased to speak with Amir Fathi, Massachusetts General Hospital...

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Menin inhibitors in AML: Bridging the gap between trial data and clinical practice

Menin inhibitors in AML: Bridging the gap between trial data and clinical practice

The AML Hub was pleased to speak with Emma Searle, The Christie NHS Foundation Trust, Manchester, UK. We asked for her thoughts on the topic “Menin inhibitors in AML: Bridging the gap between trial da...

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During a meeting of the AML Hub Steering Committee, held on July 22, 2025, Charles Craddock chaired a discussion on the topic: Addressing uncertainty in patient selection for transplant. The discussio...

22 Sep 202523min

Integrating menin inhibitors into the treatment landscape of AML: Future directions

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The AML Hub was pleased to speak with Joshua Zeidner, Associate Professor of Medicine at the University of North Carolina Lineberger Comprehensive Cancer Center in Durham, North Carolina. We asked for...

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